Overview
- Editors:
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Fredda Ginsberg-Fellner
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Division of Pediatric Endocrinology and Metabolism, Mount Sinai School of Medicine, New York, USA
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Robert C. McEvoy
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Mount Sinai School of Medicine, New York, USA
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Table of contents (11 chapters)
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- Thomas Mandrup-Poulsen, Jørn Nerup
Pages 1-28
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- Helga Gleichmann, Gian Franco Bottazzo
Pages 68-86
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- Heike Bärmeier, Michael Christie, Betsy Herold, Kevan Herold, Åke Lernmark
Pages 87-104
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- R. C. Nayak, G. S. Eisenbarth
Pages 105-146
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- Robert C. McEvoy, Nancy M. Thomas
Pages 165-183
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- Yi Wang, Liming Hao, Kevin J. Lafferty
Pages 184-205
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Back Matter
Pages 283-296
About this book
It has been a challenge for us to edit this volume of Endocrinology and Metabo lism: Progress in Research and Clinical Practice. The topic of the pathogenesis of insulin-dependent, type I diabetes mellitus is particularly appropriate for this series, since advances in this area have been made, to a large extent, by applying state-of-the-art laboratory techniques to clinical samples. Over the last several years, a number of lines of evidence have been gathered, suggesting that classic type I diabetes mellitus results from the autoimmune des truction of pancreatic beta-cells in genetically susceptible individuals. This hypothesis is particularly appealing because it offers a rational approach to the prevention of diabetes by immunosuppression. We have tried to present a balanced, authoritative summary of the information currently available to support the autoimmune hypothesis for the pathogenesis of human type I diabetes, to place this information in historical perspective, to include relevant information from animal models of type I diabetes in which more invasive experimentation is ethical, and, finally, to update the reader on the current status of attempts to intervene in the progression of diabetes with immunosuppressive drugs. New York, New York Fredda Ginsberg-Fellner Robert C. McEvoy Contents Preface.. . . .. .. .. . . . . . . . . . . . . ... . . . . . . . . . . . .. . . . . . . .. . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Xl . . . . . . . . . . . . . 1. The Autoimmune Hypothesis of Insulin-Dependent Diabetes: 1965 to the Present . . . . . . . . . . . . ..................... . . . . . .
Editors and Affiliations
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Division of Pediatric Endocrinology and Metabolism, Mount Sinai School of Medicine, New York, USA
Fredda Ginsberg-Fellner
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Mount Sinai School of Medicine, New York, USA
Robert C. McEvoy