Skip to main content
SpringerLink
Log in

The Humoral Anti-Islet Immune Response: Immunochemical Studies of Glycoconjugate Antigens

  • Chapter
Book cover Autoimmunity and the Pathogenesis of Diabetes

Part of the book series: Endocrinology and Metabolism ((EAM,volume 4))

Abstract

In 1974, two reports established the existence of islet-cell autoantibodies in patients having type I diabetes mellitus.1,2 These circulating anti-islet-cell autoantibodies were detected by indirect immunofluorescence on a substrate of unfixed, fresh frozen, human pancreas sections. Since this initial demonstration, it has been shown that type I diabetes has a prodromal phase during which islet-cell autoantibodies can be demonstrated in the circulation3–6 and that islet-cell antibodies are an important predictive hallmark of type I diabetes mellitus.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bottazzo GF, Florin-Christensen A, Doniach D. Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine diseases. Lancet 1974;ii:1279–1283.

    Article  Google Scholar 

  2. MacCuish AC, Barnes EW, Irvine WJ, et al. Antibodies to pancreatic islet cells in insulin dependent diabetics with coexistent autoimmune disease. Lancet 1974;ii:1529–1531.

    Article  Google Scholar 

  3. Betterle C, Zanette F, Tiengo A, et al. Five year follow up of non-diabetes with islet cell antibodies. Lancet 1982;i:284–285.

    Article  Google Scholar 

  4. Asplin CM, Cooney MK, Crossley JR, et al. Coxsackie B4 infection and islet cell antibodies three years before overt diabetes. J Pediatr1982; 101: 398 – 400.

    Article  PubMed  CAS  Google Scholar 

  5. Gorsuch AN, Spencer KM, Lister J, et al. Evidence for a long prediabetic period in Type I (insulin dependent) diabetes mellitus. Lancet 1981;ii:1363–1365.

    Article  Google Scholar 

  6. Srikanta S, Ganda OP, Eisenbarth GS, et al. Islet cell antibodies and beta cell function in monozygotic triplets and twins initially discordant for Type I diabetes mellitus. N Engl J Med1983; 308: 322 – 325.

    Article  PubMed  CAS  Google Scholar 

  7. Dean BM, Bottazzo GF, Cudworth AG. IgG subclass distribution in organ specific autoantibodies. The relationship to complement fixing ability. Clin Exp Immunol1983; 52: 61 – 66.

    PubMed  CAS  Google Scholar 

  8. Omar MAK, Srikanta S, Eisenbarth GS. Human islet cell antibodies: Immunoglobulin class and subclass distribution defined by monoclonal antibodies. Diabetes Res1987; 4: 155 – 157.

    PubMed  CAS  Google Scholar 

  9. Schatz DA, Barrett DJ, MacLaren NK, et al. Polyclonal nature of islet cell antibodies in insulin-dependent diabetes. Autoimmunity1988; 1: 45 – 50.

    Article  PubMed  CAS  Google Scholar 

  10. Nayak RC, Omar MAK, Rabizadeh A, et al. Cytoplasmic islet cell antibodies: Evidence that the target antigen is a sialoglycoconjugate. Diabetes1985; 34: 617 – 619.

    Article  PubMed  CAS  Google Scholar 

  11. Nayak RC, Colman PG, Eisenbarth GS. How are monoclonal antibodies related to autoimmune serology? in Doniach D, Bottazzo GF (eds.): Bailliérés Clinical Immunology and Allergy: Endocrine and other Organ-Oriented Autoimmune Disorders. London: Bailliére Tindall Ltd., 1987, pp. 81 – 99.

    Google Scholar 

  12. Srikanta S, Eisenbarth GS. Islet cell antigens: Initial studies of their biology and function. Mol Biol Med1986; 3: 113 – 127.

    PubMed  CAS  Google Scholar 

  13. Hakomori, S-I. Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. Ann Rev Biochem1981; 50: 733 – 764.

    Article  PubMed  CAS  Google Scholar 

  14. Curatolo W. The physical properties of glycolipids. Biochim Biophys Acta1987; 906: 111 – 136.

    PubMed  CAS  Google Scholar 

  15. Curatolo W. Glycolipid function. Biochim Biophys Acta1987; 906: 137 – 160.

    PubMed  CAS  Google Scholar 

  16. IUPAC-IUB Commission on Biochemical Nomenclature (CBN). Nomenclature of lipids recommendations 1976. Eur J Biochem1977; 79: 11 – 21.

    Article  Google Scholar 

  17. Svennerholm L. Chromatographic separation of human brain gangliosides. J Neurochem1963; 10: 613 – 623.

    Article  PubMed  CAS  Google Scholar 

  18. Muresan V, Sarras MP Jr, Jamieson JD. Distribution of sialoglycoconjugates on acinar cells of the mammalian pancreas. J Histochem Cytochem1987; 30: 947 – 955.

    Article  Google Scholar 

  19. Colman PG, Nayak RC, Campbell IL, et al. Binding of cytoplasmic islet cell antibodies is blocked by human pancreatic glycolipid extracts. Diabetes1988; 37: 645 – 652.

    Article  PubMed  CAS  Google Scholar 

  20. Svennerholm L, Fredman PA. A procedure for the quantitative isolation of brain gangliosides. Biochim Biophys Acta1980; 617: 97 – 109.

    PubMed  CAS  Google Scholar 

  21. Svennerholm L, Fredman PA. A procedure for the quantitative isolation of brain gangliosides. Biochim Biophys Acta1980; 617: 97 – 109.

    PubMed  CAS  Google Scholar 

  22. Shienvold FL, Guinguis-Petasne S, Rabinovitch A, et al. Glycolipids as autoantigens in BB/Worcester rats. International Research Symposium, “The Immunology of Diabetes” American Diabetes Association, Woods Hole, MA, Oct 27–30, 1987, Abstr. 115.

    Google Scholar 

  23. Hofstetter W, Heusser CH, Blaser K. Nonspecific binding of mouse IgM antibodies to lipid antigens. J Neuroimmunol1985; 7: 207 – 214.

    Article  PubMed  CAS  Google Scholar 

  24. Dotta F, Bonner-Weir S, Cahill C, et al. Immunoreactivity of islet tumor cells: A new diabetes-associated antigen. Clin Res1988; 36: 480A.

    Google Scholar 

  25. Eisenbarth GS, Walsh FS, Nirenberg M. Monoclonal antibody to a plasma membrane antigen of neurons. Proc Natl Acad Sci USA1979; 76: 4913 – 4917.

    Article  PubMed  CAS  Google Scholar 

  26. Eisenbarth GS, Shimizu K, Bowring MA, et al. Expression of receptors for tetanus toxin and monoclonal antibody A2B5 by pancreatic islet cells. Proc Natl Acad Sci USA1982; 79: 5066 – 5070.

    Article  PubMed  CAS  Google Scholar 

  27. Kasai N, Yu RK. The monoclonal antibody A2B5 is specific to ganglioside GQlc. Brain Res1983; 277: 155 – 158.

    Article  PubMed  CAS  Google Scholar 

  28. Kundu SK, Pleatman MA, Redwin WA, et al. Binding of monoclonal antibody A2B5 to gangliosides. Biochem Biophys Res Commun1983; 116: 836 – 842.

    Article  PubMed  CAS  Google Scholar 

  29. Fredman P, Magnani JL, Nirenberg M, et al. Monoclonal antibody A2B5 reacts with many gangliosides in neuronal tissue. Arch Biochem Biophys1984; 233: 661 – 666.

    Article  PubMed  CAS  Google Scholar 

  30. Powers AC, Rabizadeh A, Akeson R, et al. Characterization of monoclonal antibody 3G5 and utilization of this antibody to immobilize pancreatic islet cell gangliosides in a solid phase radioassay. Endocrinology1984; 114: 1338 – 1343.

    Article  PubMed  CAS  Google Scholar 

  31. Nayak RC, Colman PG, Halban PA, et al. Identification and purification of islet ganglioside antigen 3G5 and islet cell autoantigen from human pancreas. Diabetes 1987; 36(Suppl 1):64A.

    Google Scholar 

  32. Rabinowe SL, Nayak RC, Krisch K, et al. Aging in man: Linear increase of a novel T-cell subset defined by antiganglioside monoclonal antibody 3G5. J Exp Med1987; 165: 1436 – 1441.

    Article  PubMed  CAS  Google Scholar 

  33. Rabinowe SL, Larsen PR, Antman EM, et al. Autoimmune thyroid disease: Evaluation of a new monoclonal antibody defined T-cell subset. Am J Med1986; 81: 53 – 57.

    Article  PubMed  CAS  Google Scholar 

  34. Nayak RC, Berman AB, George KL, et al. A monoclonal antibody (3G5)-defined ganglioside antigen is expressed on the cell surface of microvascular pericytes. J Exp Med1988; 167: 1003 – 1015.

    Article  PubMed  CAS  Google Scholar 

  35. Nayak RC, Berman AB, King GL. Identification of a common antigen shared by retinal capillary pericytes and pancreatic beta cells using a monoclonal antibody (3G5). Invest Ophthalmol Vis Sci 1987;28(ARVO suppl):56 abstr.

    Google Scholar 

  36. Uchigata Y, Spitalnik SL, Tachiwaki O, et al. Pancreatic islet cell surface glycoproteins containing Galβ1-4GlcNac-R identified by a cytotoxic monoclonal autoantibody. J Exp Med1987; 165: 124 – 139.

    Article  PubMed  CAS  Google Scholar 

  37. Spitalnik SL, Danley JM, Uchigata Y, et al. An islet cell specific human monoclonal autoantibody from a patient with Type I diabetes recognizes a monosialoganglioside. International Research Symposium “The Immunology of Diabetes” American Diabetes Association, Woods Hole, MA, Oct. 27–30, 1987, Abstr. 113.

    Google Scholar 

  38. Alejandro R, Shienvold FL, Vaerewyck-Hajek SA, Pierce M, et al. A ganglioside antigen on the rat pancreatic B-cell surface identified by monoclonal antibody R2D6. J Clin Invest1984; 74: 25 – 38.

    Article  PubMed  CAS  Google Scholar 

  39. Thomas JW, Virta VJ, Nell LJ. Cell surface antigens on rat islet tumors. J Immunol1987; 138: 2896 – 2901.

    PubMed  CAS  Google Scholar 

  40. Dib SA, Colman PG, Dotta F, et al. Expression of cytoplasmic islet cell antigens by rat pancreas. Diabetes1987; 36: 982 – 985.

    Article  PubMed  CAS  Google Scholar 

  41. Hahn HJ, Hellman B, Lernmark A, et al. The pancreatic beta cell recognition of insulin secretagogues. J Biol Chem1974; 249: 5275 – 5284.

    PubMed  CAS  Google Scholar 

  42. Nielsen DA, Welsh M, Casadaban MJ, et al. Control of insulin gene expression in pancreatic beta cells and in an insulin-producing cell line, RIN-5F cells. J Biol Chem1985; 260: 13585 – 13589.

    PubMed  CAS  Google Scholar 

  43. Marcus DM. A review of the immunogenic and immunomodulatory properties of glycosphingolipids. Mol Immunol1984; 21: 1083 – 1091.

    Article  PubMed  CAS  Google Scholar 

  44. Ilyas AA, Quarles RH, Dalakas MC, et al. Polyneuropathy with monoclonal gammopathy: Glycolipids are frequently antigens for IgM paraproteins. Proc Natl Acad Sci USA1985; 82: 6697 – 6700.

    Article  PubMed  CAS  Google Scholar 

  45. Leibowitz A, Gregson NA, Kennedy M, et al. IgM paraproteins with immunological specificity for a Schwann cell component and peripheral nerve myelin in patients with polyneuropathy. J Neurol Sci1983; 53: 153 – 165.

    Article  Google Scholar 

  46. Ilyas AA, Quarles RH, MacIntosh TD, et al. IgM in a human neuropathy related to paraproteinemia binds to a carbohydrate determinant in the myelin-associated glycoprotein and to a ganglioside. Proc Natl Acad Sci USA1984; 81: 1225 – 1229.

    Article  PubMed  CAS  Google Scholar 

  47. Chou KH, Ilyas AA, Evans JE, et al. Structure of a glycolipid reacting with monoclonal IgM in neuropathy and with HNK-1. Biochem Biophys Res Commun1985; 128: 383 – 388.

    Article  PubMed  CAS  Google Scholar 

  48. Adams DD. Thyroid stimulatory autoantibodies. Vitam Horm1980; 38: 119 – 203.

    Article  PubMed  CAS  Google Scholar 

  49. Drexhage HA, van der Gaag RD, Wulffraat NM. The multiplicity of stimulating and blocking autoantibodies in relation to thyroid and extrathyroidal tissues, in Doniach D, Bottazzo GF (eds): Bailliére’s Clinical Immunology and Allergy: Endocrine and Other Organ-Oriented Autoimmune Disorders. London: Bailliére Tindall Ltd., 1987, pp. 125 – 140.

    Google Scholar 

  50. Kohn LD, Yavin E, Yavin Z, et al. Autoimmune thyroid disease studied with monoclonal antibodies to the thyrotropin receptor, in Haynes BF, Eisenbarth GS (eds): Monoclonal Antibodies-Probes for the Study of Autoimmunity and Immunodeficiency. Orlando, FA: Academic Press, 1983, pp 221 – 258.

    Google Scholar 

  51. Feizi T, Hadler N. Autoantibodies and disease, in Elkeles RS, Tavill AS (eds): Biochemical Aspects of Human Disease. Oxford, England: Blackwell Scientific, 1983, pp 656 – 692.

    Google Scholar 

  52. Hirano T, Hashimoto H, Shiokawa Y. Antiglycolipid autoantibody detected in the sera from systemic lupus erythematosus patients. J Clin Invest1980; 60: 1437 – 1440.

    Article  Google Scholar 

  53. Endo T, Scott DD, Stewart SS, et al. Antibodies to glycosphingolipids in patients with multiple sclerosis and SLE. J Immunol1984; 132: 1793 – 1797.

    PubMed  CAS  Google Scholar 

  54. Kibler RF, Fritz RB, Chou FC-H, et al. Immune response of Lewis rats to peptide C1 (residues 68–88) of guinea pig and rat myelin basic proteins. J Exp Med1977; 146: 1323 – 1331.

    Article  PubMed  CAS  Google Scholar 

  55. Hirsch HE, Parks ME. Serological reactions against glycolipid-sensitized liposomes in multiple sclerosis. Nature1976; 264: 785 – 787.

    Article  PubMed  CAS  Google Scholar 

  56. Arnon R, Crisp E, Kelley R, et al. Anti-ganglioside antibodies in multiple sclerosis. J Neurol Sci1980; 46: 179 – 186.

    Article  PubMed  CAS  Google Scholar 

  57. Fry JM, Weissbarth S, Lehrer GM. Cerebroside antibody inhibits sulfatide synthesis and myelination and demyelinates in cord tissue cultures. Science1974; 183: 540 – 542.

    Article  PubMed  CAS  Google Scholar 

  58. Schwerer B, Kitz K, Lassmann H, et al. Serum antibodies against glycosphingolipids in chronic relapsing experimental allergic encephalomyelitis. J Neuroimmunol1984; 7: 107 – 119.

    Article  PubMed  CAS  Google Scholar 

  59. Decerf-Etienne J, Malaise M, Mahieu P, et al. Elevated anti-galactosyl antibody titres: A marker of progression in autoimmune thyroid disorders and in endocrine ophthalmopathy? Acta Endocrinol1987; 115: 67 – 74.

    Google Scholar 

  60. Spiro RC, Bhoyroo VD. Occurrence of α-D-galactosyl residues in thyroglobulin from several species. Localization in the saccharide chains of the complex carbohydrate units. J Biol Chem1984; 259: 9858 – 9866.

    PubMed  CAS  Google Scholar 

  61. Kress BC, Spiro RG. Studies on the glycoprotein nature of the thyrotropin receptor: Interaction with lectins and purification of the bovine protein with the use of Bandeiraea (Griffonia) simplicifolia I affinity chromatography. Endocrinology1986; 118: 974 – 979.

    Article  PubMed  CAS  Google Scholar 

  62. Galili U, Basbaum CB, Shohet SB, et al. Identification of erythrocyte Galα 1–3Gal glycosphingolipids with a mouse monoclonal antibody, Gal-13. J Biol Chem1987; 262: 4683 – 4688.

    PubMed  CAS  Google Scholar 

  63. Witkin SS, Sonnabend J, Richards JM, et al. Induction of antibody to asialo GM1 by spermatozoa and its occurrence in the sera of homosexual men with the acquired immune deficiency syndrome (AIDS). Clin Exp Immunol1983; 54: 346 – 350.

    PubMed  CAS  Google Scholar 

  64. Yasuda T, Ueno J, Matuhasu T. Antiglycolipid antibodies in Behcet’s disease, in Inaba G (ed): Behcet’s Disease: Pathogenetic Mechanism and Clinical Future. Tokyo: University of Tokyo Press, 1981, pp 413 – 420.

    Google Scholar 

  65. Inaba G, Aoyama J. Anti-glycolipid antibodies in neuro-Behcet’s syndrome, in Inaba G (ed): Behcet’s Disease: Pathogenetic Mechanism and Clinical Future. Tokyo: University of Tokyo Press, 1981, pp 145 – 152.

    Google Scholar 

  66. Higashi H, Naiki M. Antigen of “serum sickness” type of heterophile antibodies in human sera: Identification as gangliosides with N-glycolylneuraminic acid. Biochem Biophys Res Commun1977; 79: 388 – 395.

    Article  PubMed  CAS  Google Scholar 

  67. Mukuria CJ, Fujii Y, Kato S, et al. Specificities of human heterophile Hanganutziu and Deicher (H-D) antibodies to glycosphingolipids and a glycoprotein. J Biochem1986; 100: 469 – 475.

    PubMed  CAS  Google Scholar 

  68. Naiki M, Higashi H. Detection of antibodies to gangliosides in pathologic human sera. Serum sickness type heterophile antibodies. Adv Exp Med Biol1979; 125: 359 – 367.

    Google Scholar 

  69. Kasukawa R, Kyoichi K, Bloom ML, et al. Heterophile antibodies in pathologic human sera resembling antibodies stimulated by foreign species sera. Clin Exp Immunol1976; 25: 122 – 132.

    PubMed  CAS  Google Scholar 

  70. Naiki M, Fujii Y, Ikuta K, et al. Expression of Hanganutziu and Deicher type heterophile antigen on the cell surface of Marek’s disease lymphoma, in Makita A, Handa S, Taketomi T, Nagai Y (eds): New Vistas in Glycolipid Research. New York/London: Plenum Publishing, 1982, pp 445 – 456.

    Google Scholar 

  71. Yasuda T, Ueno J, Naito Y, et al. Antiglycolipid antibodies in human sera, in Makita A, Handa S, Taketomi T, Nagai Y (eds): New Vistas in Glycolipid Research. New York/London: Plenum Publishing 1982, p 457 – 465.

    Google Scholar 

  72. Rapport MM, Graf L, Huang Y-YL, et al. Antibodies to total brain gangliosides: Titer and specificity of antisera. Adv Exp Med Biol1979; 125: 327 – 334.

    Google Scholar 

  73. Marcus DM, Kundu SK. Preparation and properties of antibodies to gangliosides. Adv Exp Med Biol1979; 125: 321 – 326.

    Google Scholar 

  74. Rapport MM, Huang Y-Y. Present status of the immunology of gangliosides. Adv Exp Med Biol1984; 174: 15 – 25.

    PubMed  CAS  Google Scholar 

  75. Watarai S, Handa S, Tadakuma T, et al. Application of liposomes to generation of monoclonal antibody to glycosphingolipid: Production of monoclonal antibody to GgOse4Cer. J Biochem1987; 102: 59 – 67.

    PubMed  CAS  Google Scholar 

  76. Fredman P, Mattsson L, Andersson K, et al. Characterisation of the binding epitope of a monoclonal antibody to sulphatide. Biochem J1988; 251: 17 – 22.

    PubMed  CAS  Google Scholar 

  77. Bottazzo GF, Dean BM, McNally JM, et al. In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N Engl J Med1985; 313: 353 – 360.

    Article  PubMed  CAS  Google Scholar 

  78. Jackson RA, Morris MA, Haynes BF, et al. Increased circulating Ia-antigen-bearing T cells in Type I diabetes mellitus. N Engl J Med1982; 306: 785 – 788.

    Article  PubMed  CAS  Google Scholar 

  79. Bougneres PF, Carel JC, Castano L, et al. Factors associated with early remission of Type I diabetes in children treated with cyclosporine. N Engl J Med1988; 318: 663 – 670.

    Article  PubMed  CAS  Google Scholar 

  80. Wicker LS, Miller BJ, Mullen Y. Transfer of autoimmune diabetes mellitus with splenocytes from non-obese diabetic (NOD) mice. Diabetes1986; 35: 855 – 860.

    Article  PubMed  CAS  Google Scholar 

  81. Mordes JP, Rossini AA. Keys to understanding autoimmune diabetes mellitus: The animal models of insulin dependent diabetes mellitus, in Doniach D, Bottazzo GF (eds): Bailliérés CLinical Immunology and Allergy: Endocrine and Other Organ-Oriented Autoimmune Disorders. London: Bailliére Tindall Ltd., 1987, pp 29 – 52.

    Google Scholar 

  82. Miller BJ, Appel MC, O’Neil JJ, et al. Both the LYT-2 and L3T4 T cell subsets are required for the transfer of diabetes in nonobese diabetic mice. J Immunol1988; 140: 52 – 58.

    PubMed  CAS  Google Scholar 

  83. Jacob CO, Arnon R, Sela M. Effect of carrier on the immunogenic capacity of synthetic cholera vaccine. Mol Immunol1985; 22: 1333 – 1339.

    Article  PubMed  CAS  Google Scholar 

  84. Bellamy A, Davison AN, Feldmann M. Derivation of ganglioside-specific T-cell lines of suppressor or helper phenotype from cerebrospinal fluid of multiple sclerosis patients. J Neuroimmunol1986; 12: 107 – 120.

    Article  PubMed  CAS  Google Scholar 

  85. Offner H, Konat G. Stimulation of active E-rosette forming lymphocytes,from multiple sclerosis patients by gangliosides and cerebrosides. J Neurol Sci1980; 46: 101 – 104.

    Article  PubMed  CAS  Google Scholar 

  86. Offner H, Konat G, Delia BA. Multi-sialo brain gangliosides are powerful stimulators of active E-rosetting lymphocytes from multiple sclerosis patients. J Neurol Sci1981a; 52: 279 – 287.

    Article  CAS  Google Scholar 

  87. Ilyas AA, Davison AN. Cellular hypersensitivity to gangliosides and myelin basic protein in multiple sclerosis. J Neurol Sci1983; 59: 85 – 95.

    Article  PubMed  CAS  Google Scholar 

  88. Handman E, Greenblatt CL, Goding JW. An amphipathic sulphated glycoconjugate of Leishmania: Characterization with monoclonal antibodies. The European Molecular Biology Organisation J1984; 3: 2301 – 2306.

    CAS  Google Scholar 

  89. Handman E, Goding JW. The Leishmania receptor for macrophages is a lipid containing glycoconjugate. The European Molecular Biology Organisation J1985; 4: 329 – 336.

    CAS  Google Scholar 

  90. Mitchell GF, Handman E. The glycoconjugate derived from a Leishmania major receptor for macrophages is a suppressogenic, disease-promoting antigen in murine cutaneous leishmaniasis. Parasite Immunol1986; 8: 255 – 263.

    PubMed  CAS  Google Scholar 

  91. Scott P, Pearce E, Natovitz P, et al. Vaccination against cutaneous leishmaniasis in a murine model: II. Immunologic properties of protective and non-protective subfractions of a soluble promastigote extract. J Immunol1987; 139: 3118 – 3125.

    PubMed  CAS  Google Scholar 

  92. Handman E, Mitchell GF. Immunization with leishmania receptor for macrophages protects mice against cutaneous leishmaniasis. Proc Natl Acad Sci USA1985; 82: 5910 – 5914.

    Article  PubMed  CAS  Google Scholar 

  93. Titus RG, Lima GC, Engers HD, et al. Exacerbation of murine cutaneous leishmaniasis by adoptive transfer of parasite-specific helper T-cell populations capable of mediating leishmania major-specific delayed-type hypersensitivity. J Immunol1984; 133: 1594 – 1600.

    PubMed  CAS  Google Scholar 

  94. Wilberz S, Herberg L, Renold AE, et al. Ganglioside (Cronassial®) treatment depresses diabetes incidence in NOD mice, not, however, in BB rats. Lessons from Animal Diabetes II, Second International Workshop, Geneva Switzerland. Sept. 9–13, 1987, Abstr 252.

    Google Scholar 

  95. Offner H, Thieme T, Vandenbart AA. Gangliosides induce selective modulation of CD4 from helper T lymphocytes. J Immunol1987; 139: 3295 – 3305.

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. R. C. Nayak
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. S. Eisenbarth
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Pediatric Endocrinology and Metabolism, Mount Sinai School of Medicine, 10029-6574, New York, New York, USA

    Fredda Ginsberg-Fellner M.D. (Professor of Pediatrics, Director) (Professor of Pediatrics, Director)

  2. Mount Sinai School of Medicine, 10029-6574, New York, New York, USA

    Robert C. McEvoy M.D. (Professor of Pediatrics (Endocrinology) and Cell Biology) (Professor of Pediatrics (Endocrinology) and Cell Biology)

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag New York Inc.

About this chapter

Cite this chapter

Nayak, R.C., Eisenbarth, G.S. (1990). The Humoral Anti-Islet Immune Response: Immunochemical Studies of Glycoconjugate Antigens. In: Ginsberg-Fellner, F., McEvoy, R.C. (eds) Autoimmunity and the Pathogenesis of Diabetes. Endocrinology and Metabolism, vol 4. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3218-6_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-3218-6_6

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7920-4

  • Online ISBN: 978-1-4612-3218-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation