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Profiling the molecular and physiological effects of senolytic treatment on aged mice identifies immune, fibrotic and metabolic remodeling
Although senolytics such as dasatinib and quercetin (D+Q) show promise in modulating aging, their tissue-specific efficacy and optimal intervention...
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Revealing competitive interfacial reactions in high-energy Li–S batteries
Charge transfer at solid–liquid interfaces plays a critical role in various energy-storage systems
1 , particularly under dynamically varying reactant...
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Breastfeeding status, micronutrient biomarkers, thyroid function, and Bayley-III developmental outcomes in Taiwanese toddlers
BackgroundBreastfeeding is generally associated with favorable neurodevelopmental outcomes, but toddlers who continue receiving breast milk may...
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2’’-O-galloylhyperin as a novel adjuvant to reduce imipenem resistance in multidrug-resistant Pseudomonas aeruginosa: transcriptome-based mechanism of iron homeostasis disruption
Imipenem, a critical antibiotic for treating multidrug-resistant Pseudomonas aeruginosa, now faces severe resistance from this pathogen. This study...
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A deep learning-ensemble framework for Pre-Meiyu season definition and synoptic-local weather classification
This study presents a deep learning framework to objectively classify Pre-Meiyu season synoptic weather types and their linkage to regional rainfall...
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Artificial intelligence for detecting fetal orofacial clefts and advancing medical education
Orofacial clefts are among the most common congenital craniofacial abnormalities, yet accurate prenatal detection remains challenging due to the...
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Identifying molecular signatures of parapneumonic effusion reveals HMGB2 as the disease progression biomarker
BackgroundParapneumonic effusion (PPE) exacerbation is associated with high morbidity and mortality in pneumonia patients. However, the molecular...
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Real-world clinical and economic evaluation of remote programming for deep brain stimulation in Parkinson’s disease
Deep brain stimulation (DBS) is an established therapy for Parkinson’s disease, yet conventional onsite programming mandates frequent travel to...
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Measurement of reactor neutrino oscillation with the first JUNO data
Neutrino oscillations (see refs.
1 ,2 and references therein), a quantum effect manifesting at macroscopic scales, are governed by lepton flavour...
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In situ nanocrystal confinement for efficient blue perovskite LEDs
Metal halide perovskites have emerged as promising semiconductors for light-emitting diodes (LEDs) owing to their excellent luminescence properties
1 ....
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A thalamus–brainstem attractor network drives history-biased decisions
Natural environments often change gradually, making it adaptive to bias decisions on the basis of the recent past — a phenomenon known as serial...
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RANBP1 promotes oral cancer progression through activating YAP1 and NDUFB3 derived from the database of single-cell sequencing
Oral cavity squamous cell carcinoma (OSCC) is the most common head and neck cancer, thriving in microenvironments composed of cancer cells, stromal...
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Crystallinity-guided hybrid conversion for efficient ultrawide-bandgap perovskites in triple-junction solar cells
Hybrid two-step deposition offers a scalable route for fabricating metal halide perovskites in tandem architectures, particularly for achieving...
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Cortical representation of motion sequence processing in younger and older adults: an fMRI study
Processing motion sequences is essential for daily activities such as driving. While aging affects various cognitive and neural functions, how older...
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BOPPPS model with virtual simulation system for otorhinolaryngology head and neck surgery nursing interns: a quasi-experimental study
BackgroundClinical training in surgical nursing faces limitations in safety and consistency. A virtual simulation system addresses safety but lacks...
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Low-temperature molten salt synthesis of tetragonal BaTiO3 crystals from industrial TiO2: structure control and byproduct removal
BaTiO3 crystals are known as the backbone of the modern electronic ceramics industry. The industrial synthesis of nanoscale tetragonal BaTiO3(t-BT)...
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cPLA2α inhibition potentiates anti-PD-1 immunotherapy in lung adenocarcinoma via remodeling tumor microenvironment
Although immune checkpoint inhibitors (ICIs) against PD-1/PD-L1 have revolutionized lung adenocarcinoma (LUAD) therapy, resistance and low response...
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Multi-responsive retinomorphic sensor for reconfigurable optoelectronic computing
Shifting the computing unit from back-end electronic processors to sensors or front-end free-space optics has emerged as a promising solution for...
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Antioxidant lipid nanoparticles enhance mRNA stability for regeneration therapy and gene editing
The success of mRNA vaccines has motivated the development of mRNA therapeutics to treat a wide range of diseases, as well as applications in...
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Quantum coherent beating in polar disubphthalocyanine-fullerene cocrystals for ultrafast photothermal conversion
Cocrystallization is an effective pathway for enhancing the performance of optoelectronic devices. Here a dumbbell-shaped disubphthalocyanine...
