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Factors associated with adverse haemodynamic events during the STARRT-AKI trial: a post-hoc secondary analysis
IntroductionHaemodynamic adverse events related to renal replacement therapy are a complication of all RRT modalities used in the ICU, including...
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Sex differences in hemodynamics and outcomes after transcatheter aortic valve replacement
BackgroundWomen remain underrepresented in transcatheter aortic valve replacement (TAVR) trials, despite well-recognized anatomical differences that...
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Target trial emulation to evaluate the effect of immune-related adverse events on outcomes in metastatic urothelial cancer
BackgroundImmune checkpoint inhibitors (ICIs) are an important therapeutic pillar in metastatic urothelial carcinoma (mUC). The occurrence of...
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The predictive value of highly malignant EEG patterns after cardiac arrest: evaluation of the ERC-ESICM recommendations
PurposeThe 2021 guidelines endorsed by the European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) recommend...
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High burden of acute respiratory tract infections leading to hospitalization at German pediatric hospitals: fall/winter 2022–2023
PurposeGiven reduced immunity levels for seasonally occurring respiratory infections and the experience of an unusually early, severe wave of RSV...
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Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial
BackgroundThere is controversy regarding the optimal renal-replacement therapy (RRT) modality for critically ill patients with acute kidney injury...
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The effect of recombinant erythropoietin on long-term outcome after moderate-to-severe traumatic brain injury
PurposeRecombinant erythropoietin (EPO) administered for traumatic brain injury (TBI) may increase short-term survival, but the long-term effect is...
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Clinical improvement of DM1 patients reflected by reversal of disease-induced gene expression in blood
BackgroundMyotonic dystrophy type 1 (DM1) is an incurable multisystem disease caused by a CTG-repeat expansion in the DM1 protein kinase (DMPK)...
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Impact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trial
PurposeTo assess whether pre-existing chronic kidney disease (CKD) modified the relationship between the strategy for renal-replacement theraphy...
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Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial
BackgroundOptimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the...
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Identification of Δ-1-pyrroline-5-carboxylate derived biomarkers for hyperprolinemia type II
Hyperprolinemia type II (HPII) is an inborn error of metabolism due to genetic variants in ALDH4A1, leading to a deficiency in...
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A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial
BackgroundTiming of initiation of kidney-replacement therapy (KRT) in critically ill patients remains controversial. The Standard versus Accelerated...
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Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial
PurposeThe optimal ventilatory settings in patients after cardiac arrest and their association with outcome remain unclear. The aim of this study was...
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Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial
PurposeTo study the efficacy of lopinavir-ritonavir and hydroxychloroquine in critically ill patients with coronavirus disease 2019 (COVID-19).
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Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
Direct targeting of the downstream mitogen-activated protein kinase (MAPK) pathway to suppress extracellular-regulated kinase (ERK) activation in KRAS...
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Conservative oxygen therapy for mechanically ventilated adults with suspected hypoxic ischaemic encephalopathy
PurposeLiberal use of oxygen may contribute to secondary brain injury in patients with hypoxic-ischaemic encephalopathy (HIE). However, there are...
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Oxidative stress as candidate therapeutic target to overcome microenvironmental protection of CLL
Chronic lymphocytic leukemia (CLL) cells depend on microenvironmental non-malignant cells for survival. We compared the transcriptomes of primary CLL...
