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Scaffold-Based Selective ROS Generation as Viable Therapeutic Strategies Against Cancer

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Handbook of Oxidative Stress in Cancer: Mechanistic Aspects

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Abstract

Reactive oxygen species (ROS) are by-products of normal cellular metabolism and play a crucial part in cell signaling and common cellular functions. An increasing field of evidence suggests that cancer cells contain an abnormally high content of ROS, and this biochemical attribute can be utilized for selective killing. Diverse chemotherapeutic agents have been developed that attack cancerous cells through several mechanisms, such as by amplifying the cells’ intrinsic oxidative stress, by directly generating ROS, or by inhibiting antioxidant enzymes. This occurs due to their vulnerability to further ROS insults. ROS modulation cancer therapy is a young and sustained research realm for medicinal chemistry community. This chapter reviews evidence linking specific scaffolds to reactive oxygen species generation in cancer treatment and the present status of the preclinical and clinical phases of promising synthetic/natural drugs.

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Acknowledgments

M.Y. acknowledges postdoctoral fellowship support from SERB-DST (DST File No: PDF/2017/000439), New Delhi., M.T.A acknowledges DBT, Government of India, New Delhi for his doctoral research fellowship (Fellow: DBT/2016/IICT/723). R.B acknowledges the CSIR and SERB (Grant No. EMR/2017/002140), Govt. of India for financial support. This is CSIR-IICT manuscript No. IICT/Pubs./2020/154.

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Authors and Affiliations

  1. Applied Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, India

    Md Yousuf, Mohammed Tanveer Ahmed & Rajkumar Banerjee

  2. Department of Chemistry, Ramnagar College, Purba Medinipur, West Bengal, India

    Md Yousuf

  3. Academy of Scientific and Innovation Research (AcSIR), Ghaziabad, India

    Mohammed Tanveer Ahmed & Rajkumar Banerjee

  4. NanoBiotechnology Research Laboratory (NBRL), School of Science, RMIT University, Melbourne, VIC, Australia

    Mohammed Tanveer Ahmed

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  1. Md Yousuf
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  2. Mohammed Tanveer Ahmed
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  3. Rajkumar Banerjee
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Correspondence to Rajkumar Banerjee .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, USA

    Bimal K. Ray

  3. CSIR-Indian Institute of Chemical Biology, Kolkata, India

    Susanta Roychoudhury

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Yousuf, M., Ahmed, M.T., Banerjee, R. (2022). Scaffold-Based Selective ROS Generation as Viable Therapeutic Strategies Against Cancer. In: Chakraborti, S., Ray, B.K., Roychoudhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-9411-3_18

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