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Free Complex-Type N-Glycans

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Glycoscience: Biology and Medicine

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Abstract

The occurrence of free high-mannose type N-glycans is well demonstrated in mammalian cells. However, free complex-type N-glycans are not normally observed. Recent glycomic analyses of human cancers have revealed the accumulation of significant amounts of free sialylated complex-type N-glycans in pancreatic and prostate cancers. Specifically, free Neu5Ac-containing complex-type N-glycans were found to accumulate in pancreatic cancers. In addition to these free oligosaccharides, free KDN-containing complex-type N-glycans were found to accumulate in prostate cancers. By contrast, in colorectal cancers, free complex-type N-glycans were either not detected or accumulated in only trace amounts. As such, these free oligosaccharides are potentially valuable tumor markers.

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Authors and Affiliations

  1. Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Nakamichi, Higashinari-ku, Osaka, 537-8511, Japan

    Yasuhide Miyamoto

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  1. Yasuhide Miyamoto
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Correspondence to Yasuhide Miyamoto .

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Editors and Affiliations

  1. Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan

    Tamao Endo

  2. Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

    Peter H. Seeberger

  3. Dept. Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Gerald W. Hart

  4. Academia Sinica, Nankang, Taipei, Taiwan

    Chi-Huey Wong

  5. Systems Glycobiology Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Wako, Saitama, Japan

    Naoyuki Taniguchi

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© 2014 Springer Japan

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Miyamoto, Y. (2014). Free Complex-Type N-Glycans. In: Endo, T., Seeberger, P., Hart, G., Wong, CH., Taniguchi, N. (eds) Glycoscience: Biology and Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54836-2_184-1

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  • DOI: https://doi.org/10.1007/978-4-431-54836-2_184-1

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  • Publisher Name: Springer, Tokyo

  • Online ISBN: 978-4-431-54836-2

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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