Nanofiltration for reuse of Sharpless catalytic systems combines reaction and separation in a single vessel, allowing successive reaction and filtration steps, to recycle the catalytic system in successive batches with isolation of the chiral product on the permeated solution. The Sharpless catalysis is a robust strategy for production of chiral 1,2-diols from olefins at high yields and enantiomer excesses, using a catalytic system based on OsO4 or K2OsO2(OH)4 salt and a chiral dimeric ligand (Bolm et al. 2000; Kolb et al. 1994). Chiral ligands used are based on a cinchona alkaloid (dihydroquinidine or dihydroquinine) with phathalazina, pyrimidine, or indoline groups. The reaction requires a co-oxidant, which can be organic or inorganic, such as N-methylmorpholine-N-oxide (NMO) or K3Fe(CN)6, respectively. The reaction media is conventionally an aqueous/organic (50 v/v% solvent) mixture with tert-butanol, methyl tert-butyl ether, or acetone. The feasibility of Sharpless reaction was...
References
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Castelo Ferreira, F. (2012). Nanofiltration for Reuse of Sharpless Catalytic Systems. In: Drioli, E., Giorno, L. (eds) Encyclopedia of Membranes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40872-4_1149-1
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DOI: https://doi.org/10.1007/978-3-642-40872-4_1149-1
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