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Human Meniscus: From Biology to Tissue Engineering Strategies

Sports Injuries

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Abstract

Once meniscus is damaged, a cascade of events occurs leading to degenerative joint changes of the knee. The morbidity of patients can significantly increase overtime and degeneration of the cartilage can progress, resulting in arthritis. Possibilities for treatment of meniscus lesions are primordially focused in repair and replacement (e.g., acellular scaffolds and meniscus allograft transplantation). Tissue Engineering and Regenerative Medicine have been providing new options in medical practice. However, these disciplines require deep understanding of the target tissue and physiopathology of the implicated disorder. In order to overcome the current limitations, fundamental studies have been made for developing reliable strategies aiming to obtain superior tissue healing. Herein, it is presented the most relevant insights and research directions on the fundamental biology and biomechanics of meniscus. The principles of tissue engineering (triad) and the significant in vitro and in vivo reports addressing meniscus regeneration are included, once these will provide the basements for future clinical directions.

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Authors and Affiliations

  1. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, AvePark, S. Cláudio de Barco, 4806-909, Taipas, Guimarães, Portugal

    Hélder Pereira, Ibrahim Fatih Cengiz, Joana Silva-Correia, Joaquim Miguel Oliveira, Rui Luís Reis & João Espregueira-Mendes

  2. ICVS/3B’s – PT Government Associated Laboratory, Guimarães, Portugal

    Hélder Pereira, Ibrahim Fatih Cengiz, Joana Silva-Correia, Joaquim Miguel Oliveira, Rui Luís Reis & João Espregueira-Mendes

  3. Clínica Espregueira-Mendes F.C. Porto Stadium – FIFA Medical Centre of Excellence, Porto, Portugal

    Hélder Pereira & João Espregueira-Mendes

  4. Orthopedic Department, Centro Hospitalar Póvoa de Varzim, Vila do Conde, Portugal

    Hélder Pereira & João Espregueira-Mendes

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  1. Hélder Pereira
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  2. Ibrahim Fatih Cengiz
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  3. Joana Silva-Correia
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  4. Joaquim Miguel Oliveira
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Correspondence to Hélder Pereira .

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  1. Dept. Orthopedics & Traumatology, Hacettepe University Fac. Medicine, Ankara, Turkey

    Mahmut Nedim Doral

  2. Gothenburg, Sweden

    Jon Karlsson

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Pereira, H., Cengiz, I.F., Silva-Correia, J., Oliveira, J.M., Reis, R.L., Espregueira-Mendes, J. (2013). Human Meniscus: From Biology to Tissue Engineering Strategies. In: Doral, M., Karlsson, J. (eds) Sports Injuries. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36801-1_73-1

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  • DOI: https://doi.org/10.1007/978-3-642-36801-1_73-1

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  1. Latest

    Instrumentation for Arthroscopy and Sports Medicine
    Published:
    24 June 2014

    DOI: https://doi.org/10.1007/978-3-642-36801-1_252-1

  2. Original

    Human Meniscus: From Biology to Tissue Engineering Strategies
    Published:
    14 June 2014

    DOI: https://doi.org/10.1007/978-3-642-36801-1_73-1

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