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Pathophysiology of Progressive Renal Disease in Children

Pediatric Nephrology

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Abstract

Chronic kidney disease (CKD) is a condition in which an initial injury is superseded by a more gradual, chronic process of decreasing function that, in the most extreme cases, ultimately leads to the need for renal replacement therapy. An important consideration is that, while the initiating causes are quite varied, as CKD progresses the mechanisms involved become increasingly similar, so that eventually a set of common events contributes to inexorable loss of functional nephron mass. The mechanisms that are involved can be described as those that disrupt normal renal physiology and those by which decreasing structural integrity renders such disruption irreversible. Thus, the key to understanding progression is examining how function becomes dysregulated and how this dysfunction interacts with the process of renal scarring. This chapter will review these mechanisms.

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Authors and Affiliations

  1. Division of Kidney Diseases, Ann & Robert H. Lurie Children’s Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Morton 4-685G, 310 E Superior St., Chicago, IL, 60611-3008, USA

    H. William Schnaper

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  1. H. William Schnaper
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Correspondence to H. William Schnaper .

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Editors and Affiliations

  1. Children's Hospital of Wisconsin Children's Research Institute, Milwaukee, Wisconsin, USA

    Ellis D. Avner

  2. Harvard Medical School Children's Hospital Boston, Boston, Massachusetts, USA

    William E. Harmon

  3. HĂ´pital Necker Enfants Malades Dept. NĂ©phrologie PĂ©diatrique, Paris, France

    Patrick Niaudet

  4. Wakayama Medical University Dept. Pediatrics, Wakayama City, Japan

    Norishige Yoshikawa

  5. Department of Nephrology and Urology Division of Nephrology, Children's Hospital Bambino GesĂą, IRCCS, Rome, Italy

    Francesco Emma

  6. Division of Nephrology and Hypertension The Heart Institute, University of Cincinnati Cincinnati Children’s Hospital Medical C, Cincinnati, Ohio, USA

    Stuart Goldstein

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Schnaper, H.W. (2015). Pathophysiology of Progressive Renal Disease in Children. In: Avner, E., Harmon, W., Niaudet, P., Yoshikawa, N., Emma, F., Goldstein, S. (eds) Pediatric Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27843-3_58-1

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  • DOI: https://doi.org/10.1007/978-3-642-27843-3_58-1

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  • Online ISBN: 978-3-642-27843-3

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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  1. Latest

    Progression of Chronic Kidney Disease and Nephroprotection in Children
    Published:
    23 November 2021

    DOI: https://doi.org/10.1007/978-3-642-27843-3_58-2

  2. Original

    Pathophysiology of Progressive Renal Disease in Children
    Published:
    22 June 2015

    DOI: https://doi.org/10.1007/978-3-642-27843-3_58-1

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