Definition
Virology addresses the molecular nature of viruses, their genetic content, the pathway by which they enter cells and multiply using the molecular machinery of the host cell, and the mechanisms by which they elicit diseases. Tumor virology is a specialized discipline analyzing the association of particular virus types with cancers in animals and humans.
Characteristics
In 1964 the first human tumor virus, the Epstein–Barr virus (EBV), was isolated from tumor samples of a patient with African Burkitt lymphoma. Subsequently, EBV was linked to the development of other forms of cancer. In the 44 years since the discovery of EBV, other human tumor viruses have been identified (Table 1).
References
Cullen BR (2006) Viruses and microRNAs. Nat Genet 38(Suppl):S25–S30
Khan G (2006) Epstein-Barr virus, cytokines, and inflammation: a cocktail for the pathogenesis of Hodgkin’s lymphoma? Exp Hematol 34:399–406
Poulin DL, DeCaprio JA (2006) Is there a role for SV40 in human cancer? J Clin Oncol 24:4356–4365
Stanley MA (2006) Human papillomavirus vaccines. Rev Med Virol 16:139–149
Tao Q, Young LS, Woodman CB et al (2006) Epstein-Barr virus (EBV) and its associated human cancers–genetics, epigenetics, pathobiology and novel therapeutics. Front Biosci 11:2672–2713
See Also
(2012) Humanized antibodies. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 1760. doi: 10.1007/978-3-642-16483-5_2863
(2012) Monoclonal antibody. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 2367. doi: 10.1007/978-3-642-16483-5_6842
(2012) Monoclonal antibody therapy. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, pp 2367–2368. doi: 10.1007/978-3-642-16483-5_3823
(2012) P53. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 2747. doi: 10.1007/978-3-642-16483-5_4331
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer-Verlag Berlin Heidelberg
About this entry
Cite this entry
Murray, P.G. (2015). Virology. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_6195-2
Download citation
DOI: https://doi.org/10.1007/978-3-642-27841-9_6195-2
Received:
Accepted:
Published:
Publisher Name: Springer, Berlin, Heidelberg
Online ISBN: 978-3-642-27841-9
eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences