Table 1 Classification and examples of tumor antigens
From: Tumor Antigens
Antigen group | Name | Site/type of the tumor | Spontaneous immune response in cancer patients |
|---|---|---|---|
Mutated | RAS | Colon, lung, pancreas, prostate, leukemias, bladder, etc. | Humoral and cell mediated |
BRAF | Thyroid, melanoma | Humoral and cell mediated | |
BCR/ABL | CML, ALL, AML | Humoral and cell mediated | |
β-catenin | Melanoma | Cell mediated | |
CDK4 | Melanoma | Cell mediated | |
p53 | Breast, colon, lung, colon rectum, ovary, thyroid, bladder, pancreas, B-cell lymphoma, etc. | Humoral and cell mediated | |
WT1 | AML, CML, Wilms’ tumor | Humoral and cell mediated | |
Oncofetal | CEA | Colorectal, stomach, pancreas, lung, breast, gallbladder, ovary, endometrium | Humoral and cell mediated |
AFP | Testicular, liver, pancreas, lung, embryonal cell carcinoma, genitourinary tract, yolk sac (ovary) | Humoral and cell mediated | |
OFA/iLRP | Hematological, breast, mesenchymal tissue, kidney | Humoral and cell mediated | |
5T4 oncofetal antigen | Breast, kidney, colorectal, prostate, ovary | Cell mediated | |
GPC-3 | Liver, melanoma, yolk sac, stomach | Cell mediated | |
IMP-3 | Pancreas, lung, stomach, esophagus, colon, kidney, soft tissue | Cell mediated | |
hCGβ | Colon, lung, pancreas, esophagus, breast, bladder, cervix, stomach, prostate, trophoblast, testis | Cell mediated | |
Cancer testis | MAGE-A1, MAGE-A3, MAGE-A10, NY-ESO-1, SSX-2, GAGE1, KP-OVA-52, XAGE-1b | Bladder, brain, colon, head and neck, lung, liver, esophagus, melanoma, myeloma, neuroblastoma, prostate, thyroid, ovary, NHL, lung | Humoral and cell mediated |
Aberrantly glycosylated and expressed | MUC1 | Breast, pancreas, ovary, endometrium, lung, prostate, bladder, gastrointestinal tract, multiple myeloma, T-cell and some B-cell lymphomas | Humoral and cell mediated |
Thomsen–Friedenreich (TF or T) antigen | Colon, breast, bladder, prostate, liver, ovary, stomach | Humoral | |
LeY | Ovary, prostate, colon, breast, pancreas, lung, embryonal tissues, yolk sac, testis | Humoral | |
Stage-specific embryonic antigen-1 (SSEA-1) (LeX) | Colon, stomach, breast, ovary, kidney, bladder | Humoral | |
Gangliosides (GM1, GM2, GD1, GD2, GD3) | Neuroblastoma, melanoma, lung | Humoral | |
FucGM1 | Lung | Humoral | |
Tissue lineage | Melanoma differentiation antigens (tyrosinase, TYRP1/gp75, Melan-A/MART-1) | Melanoma | Cell mediated and humoral (TYRP1/gp75) |
Prostate-specific antigen (PSA) | Prostate | Humoral and cell mediated | |
Idiotype | B-cell malignancies | Humoral | |
Overexpressed | ErbB receptors (EGFR, ErbB2, ErbB3, ErbB4) | Breast, colon, head and neck, lung, pancreas, prostate, bladder | Humoral and cell mediated |
Ribosomal P0 protein | Colon, liver, head and neck, breast | Humoral | |
Ribosomal protein S6 | NHL, breast, colon, kidney | Humoral | |
Ribosomal protein L19 | Lung | Cell mediated | |
HSPs | Breast, ovary, lung, pancreas, colon, prostate, urinary tract, AML | Humoral | |
MYC | Neuroblastoma, small cell lung cancer, alveolar rhabdomyosarcoma, retinoblastoma | Humoral | |
OPN | Prostate | Humoral | |
MDM2 | CLL | Cell mediated | |
Mesothelin | Mesothelium, pancreas, ovary | Humoral and cell mediated | |
Survivin | Breast, ovary, lung, pancreas, colon, liver, prostate, glioma, esophagus meningioma, urinary tract | Humoral and cell mediated | |
Virally encoded | HPV (E6, E7) | Cervix, oral cavity | Humoral and cell mediated |
EBV (EBV-encoded nuclear antigens (EBNAs), BZLF1 protein) | B-cell malignancies, nasopharyngeal carcinoma | Humoral and cell mediated |