Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Tumor Antigens

  • Roberto Bei
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6015-8

Definition

Tumor antigens (TAs) are antigens recognized by specific immune effector cells and/or antibodies and differentially expressed (qualitatively and/or quantitatively) in the tumor tissue as compared to the normal counterpart tissue.

Characteristics

Tumor Antigens Classification, Expression, and Immune Response

TAs can be divided into tumor-specific antigens (TSAs) that are unique antigens expressed by tumor cells and not by normal cells and tumor-associated antigens (TAAs), which are also expressed by normal cells although at lower levels than in tumor cells (see also Yang and Yang 2005).

TAs include mutated antigens, oncofetal antigens ( OFs), cancertestis antigens ( CTs), aberrantly glycosylated and expressed antigens, tissue-lineage antigens, overexpressed antigens, and virally encoded antigens. Classification and examples of tumor antigens are shown in Table 1 (see also Khodadoust and Alizadeh 2014).
Table 1

Classification and examples of tumor antigens

Antigen group

Name

Sit...

Keywords

Epidermal Growth Factor Receptor Chronic Lymphocytic Leukemia Chronic Myelogenous Leukemia Esophageal Squamous Cell Carcinoma Patient Modify Vaccinia Ankara 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Clinical Sciences and Translational Medicine, Faculty of MedicineUniversity of Rome “Tor Vergata”RomeItaly