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Conjugated Linolenic Acids

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Encyclopedia of Cancer

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Synonyms

CLN

Definition

Conjugated linolenic acid (CLN) is a general term for the geometrical and positional isomers of octadecatrienoic (18:3) acid with three conjugated double bonds. Conjugated linolenic acids occur in several terrestrial plants (mainly seed oils). They include α-eleostearic acid (9cis(c),11trans(t),13t-18:3), catalpic acid (9t,11t,13c-18:3), punicic acid (9c,11t,13c-18:3), calendic acid (8t,10t,12c-18:3), and jacaric acid (8c,10t,12c-18:3) (Fig. 1). High contents of calendic acid, punicic acid, and α-eleostearic acid are found in seed oils of pot marigold, pomegranate, and tung/bitter gourd, respectively.

Fig. 1
figure 1

Structure of conjugated linolenic acids (CLN)

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References

  • Kohno H, Suzuki R, Noguchi R et al (2002) Dietary conjugated linolenic acid inhibits azoxymethane-induced colonic aberrant crypt foci in rats. Jpn J Cancer Res 93:133–142

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  • Yasui Y, Hosokawa M, Sahara T et al (2005) Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARγ in human colon cancer Caco-2 cells. Prostaglandins Leukot Essent Fatty Acids 73:212–219

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Authors and Affiliations

  1. Department of Bioresources Chemistry, Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido, Japan

    Kazuo Miyashita

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  1. Kazuo Miyashita
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Correspondence to Kazuo Miyashita .

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Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Miyashita, K. (2015). Conjugated Linolenic Acids. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_1314-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_1314-2

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  • Online ISBN: 978-3-642-27841-9

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