Skip to main content
SpringerLink
Log in

Phenolic Compounds in Catharanthus roseus

  • Reference work entry
  • First Online:
Natural Products

  • 496 Accesses

Abstract

Catharanthus roseus (L.) G. Don is one of the most important medicinal plants, mainly due to the presence of anticancer alkaloids. For many years, the phenolic composition of this species remained largely unstudied. Recently, detailed phytochemical studies using the latest analytical techniques have helped understand the complex phenolic profile of this species. Several highly glycosylated flavonoids have been found, mainly quercetin, kaempferol, and isorhamnetin derivatives. Other classes of phenolic compounds, namely benzoic acids and phenylpropanoids have also been described. Additionally, the high content in phenolic compounds turned this plant an interesting source of antioxidants whose activity has already been shown.

In this chapter, the tissue-dependant distribution of phenolics, as well as their concentrations and antioxidant activity, will be presented.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 2,999.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 549.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

Abbreviations

3-CQA:

3-O-caffeoylquinic acid

4-CQA:

4-O-caffeoylquinic acid

5-CQA:

5-O-caffeoylquinic acid

CrPrx1:

Catharanthus roseus peroxidase 1

DAD:

Diode array detection

DPPH:

2,2-diphenyl-1-picrylhydrazyl

LC-DAD:

Liquid chromatography-diode array detector

LC-DAD-ESI-MS/MS:

Liquid chromatography-diode array detector-electrospray ionization-mass spectrometry

LC-UV:

Liquid chromatography-ultraviolet detector

SIM:

Single ion monitoring

References

  1. Pelt JM (2001) Les nouveaux remedes naturels. Fayard Ed, Paris

    Google Scholar 

  2. Noble RL, Beer CT, Cutts JH (1958) Role of chance observations in chemotherapy – Vinca rosea. Ann NY Acad Sci 76:882–894

    Article  CAS  Google Scholar 

  3. Noble RL, Beer CT, Cutts JH (1958) Further biological activities of vincaleukoblastine – an alkaloid isolated from Vinca rosea (L). Biochem Pharmacol 1:347–348

    Article  Google Scholar 

  4. Svoboda GH (1961) Alkaloids of Vinca rosea (Catharanthus roseus) 9. Extraction and characterization of leurosidine and leurocristine. Lloydia 24:173

    CAS  Google Scholar 

  5. Svoboda GH, Neuss N, Gorman M (1959) Alkaloids of Vinca rosea Linn (Catharanthus roseus G-Don).5. Preparation and characterization of alkaloids. J Am Pharm Assoc 48:659–666

    CAS  Google Scholar 

  6. Noble RL (1990) The discovery of the Vinca Alkaloids – Chemotherapeutic-agents against cancer. Biochem Cell Biol 68:1344–1351

    Article  CAS  Google Scholar 

  7. Mustafa N, Verpoorte R (2007) Phenolic compounds in Catharanthus roseus. Phytochem Rev 6:243–258

    Article  CAS  Google Scholar 

  8. Robards K, Antolovich M, Prenzler P, Ryan D (2000) Sample preparation in the determination of phenolic compounds in fruits. Analyst 125:989–1009

    Article  Google Scholar 

  9. Ferreres F, Andrade PB, Valentao P, Gil-Izquierdo A (2008) Further knowledge on barley (Hordeum vulgate L.) leaves O-glycosyl-C-glycosyl flavones by liquid chromatography-UV diode-array detection-electrospray ionisation mass spectrometry. J Chromatogr A 1182:56–64

    Article  CAS  Google Scholar 

  10. Mabry TJ, Markham KR, Thomas MB (1970) The systematic identification of flavonoids. Springer, New York

    Book  Google Scholar 

  11. Riberéau-Gayon P (1968) Les composes phenoliques des végétaux. Dunod, Paris

    Google Scholar 

  12. Cuyckens F, Claeys M (2004) Mass spectrometry in the structural analysis of flavonoids. J Mass Spectrom 39:1–15

    Article  CAS  Google Scholar 

  13. Rauha JP, Vuorela H, Kostiainen R (2001) Effect of eluent on the ionization efficiency of flavonoids by ion spray, atmospheric pressure chemical ionization, and atmospheric pressure photoionization mass spectrometry. J Mass Spectrom 36:1269–1280

    Article  CAS  Google Scholar 

  14. Pereira DM, Ferreres F, Oliveira J, Valentão P, Andrade PB, Sottomayor M (2009) Targeted metabolite analysis of Catharanthus roseus and its biological potential. Food Chem Toxicol 47:1349–1354

    Article  CAS  Google Scholar 

  15. Proestos C, Chorianopoulos N, Nychas G-JE, Komaitis M (2005) RP-HPLC analysis of phenolic compounds of plant extracts. Investigation of their antioxidant capacity and antimicrobial activity. J Agric Food Chem 53:1190–1195

    Article  CAS  Google Scholar 

  16. Ferreres F, Pereira DM, Valentão P, Seabra RM, Sottomayor M, Andrade PB (2008) New phenolic compounds and antioxidant potential of Catharanthus roseus. J Agric Food Chem 56:9967–9974

    Article  Google Scholar 

  17. Pereira DM, Ferreres F, Oliveira J, Valentao P, Sottomayor M, Andrade PB (2009) Targeted metabolite analysis of Catharanthus roseus and its biological potential. Food Chem Toxicol 47:1349–1354

    Article  CAS  Google Scholar 

  18. Harrison HF Jr, Mitchell TR, Peterson JK, Wechter WP, Majetich GF, Snook ME (2008) Contents of caffeoylquinic acid compounds in the storage roots of sixteen sweetpotato genotypes and their potential biological activity. J Am Soc Hortic Sci 133:492–500

    Google Scholar 

  19. Pereira DM, Valentão P, Pereira JA, Andrade PB (2009) Phenolics: from chemistry to biology. Molecules 14:2202–2211

    Article  CAS  Google Scholar 

  20. Forsyth WGC, Simmonds NW (1957) Anthocyanidins of Lochnera rosea. Nature 180:247–247

    Article  CAS  Google Scholar 

  21. Nishibe S, Takenaka T, Fujikawa T, Yasukawa K, Takido M, Morimitsu Y, Hirota A, Kawamura T, Noro Y (1996) Bioactive phenolic compounds from Catharanthus roseus and Vinca minor. Nat Med 50:378–383

    CAS  Google Scholar 

  22. Brun G, Dijoux MG, David B, Mariotte AM (1999) A new flavonol glycoside from Catharanthus roseus. Phytochemistry 50:167–169

    Article  CAS  Google Scholar 

  23. Ferreres F, Pereira DM, Valentão P, Andrade PB, Seabra RM, Sottomayor M (2008) New phenolic compounds and antioxidant potential of Catharanthus roseus. J Agric Food Chem 56:9967–9974

    Article  Google Scholar 

  24. Piovan A, Filippini R, Favretto D (1998) Characterization of the anthocyanins of Catharanthus roseus (L.) G. Don in vivo and in vitro by electrospray ionization ion trap mass spectrometry. Rapid Commun Mass Sp 12:361–367

    Article  CAS  Google Scholar 

  25. Pereira DM, Faria J, Gaspar L, Ferreres F, Valentão P, Sottomayor M, Andrade PB (2010) Exploiting Catharanthus roseus roots: source of antioxidants. Food Chem 121:56–61

    Article  CAS  Google Scholar 

  26. Ferreres F, Figueiredo R, Bettencourt S, Carqueijeiro I, Oliveira J, Gil-Izquierdo A, Pereira DM, Valentão P, Andrade PB, Duarte P, Barceló AR, Sottomayor M (2011) Identification of phenolic compounds in isolated vacuoles of the medicinal plant Catharanthus roseus and their interaction with vacuolar class III peroxidase: an H2O2 affair? J Exp Bot 62:2841–2854

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. REQUIMTE/Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferrera n° 228, Porto, 4050-313, Portugal

    David M. Pereira (Faculdade de Farmácia), Patrícia Valentão (Faculdade de Farmácia) & Prof. Paula B. Andrade

  2. Institute for Molecular and Cell Biology (IBMC), Universidade do Porto, R. Campo Alegre 823, Porto, 4150-180, Portugal

    Mariana Sottomayor (Faculdade de Ciências)

  3. Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), 164, Campus University, 30100, Espinardo (Murcia), Spain

    Federico Ferreres

Authors
  1. David M. Pereira
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Patrícia Valentão
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mariana Sottomayor
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Federico Ferreres
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Prof. Paula B. Andrade
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Paula B. Andrade .

Editor information

Editors and Affiliations

  1. Botany Department, M.L. Sukhadia University, Durga Nursery Road, Udaipur, 313001, Rajasthan, India

    Kishan Gopal Ramawat

  2. Institute of Vine and Wine Sciences, Biological-Active Plant Substances Study, University of Bordeaux, 210 Chemin de Leysotte CS 50008, Villenave d'Ornon, 33882, France

    Jean-Michel Mérillon

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Pereira, D.M., Valentão, P., Sottomayor, M., Ferreres, F., Andrade, P.B. (2013). Phenolic Compounds in Catharanthus roseus . In: Ramawat, K., Mérillon, JM. (eds) Natural Products. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22144-6_96

Download citation

Publish with us

Policies and ethics

Search

Navigation