Skin Sensitization Testing
Guinea Pig Maximization Assay
Purpose and Rationale
A variety of methods are available for the prospective identification of skin sensitizing chemicals. The methods that have been used are the Draize rabbit irritancy test (Draize et al. 1944; Phillips et al. 1972), the occluded guinea pig patch test (Buehler 1965), and the guinea pig maximization test (Magnusson and Kligman 1969; Magnusson 1980). The guinea pig maximization test is an adjuvant sensitization test requiring intradermal injections of the test substance, in combination with Freund's complete adjuvant, which stimulates non‐specifically the immune system of treated animals, enhancing their ability to respond to sensitizing chemicals.
Procedure
Groups of 15–20 guinea pigs (Hartley strain) are used. On day 0 an area of 4 × 6 cm over the shoulder region is clipped short with an electric clipper. Three pairs of intradermal injections are made simultaneously, so that on each side of the midline there...
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References and Further Reading
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Vogel, H. (2007). Pharmacological Models in Dermatology. In: Vogel, H.G. (eds) Drug Discovery and Evaluation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-70995-4_17
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