Definition
Strategies for Engineered Negligible Senescence (SENS) is a framework for the development of a suite of therapies that repair accumulated cellular and molecular damage in aging tissues, which has been postulated to collectively postpone the biological aging process – potentially indefinitely (de Grey et al. 2002; de Grey and Rae 2007). “Negligible senescence” is a phrase coined by biogerontologist Caleb Finch to denote organisms that do not appear to exhibit age-related changes in function, risk of disease, fertility, or mortality (Finch 1994). “Engineered negligible senescence” is therefore negligible senescence resulting from medical intervention rather than from the intrinsic metabolic and structural characteristics of the organism. It is proposed that a sufficiently comprehensive suite of such therapies would progressively approach the ideal of effecting negligible...
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de Grey, A.D.N.J., Rae, M. (2019). Strategies for Engineered Negligible Senescence. In: Gu, D., Dupre, M. (eds) Encyclopedia of Gerontology and Population Aging. Springer, Cham. https://doi.org/10.1007/978-3-319-69892-2_387-1
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DOI: https://doi.org/10.1007/978-3-319-69892-2_387-1
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Strategies for Engineered Negligible Senescence- Published:
- 28 March 2021
DOI: https://doi.org/10.1007/978-3-319-69892-2_387-2
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Strategies for Engineered Negligible Senescence- Published:
- 21 May 2019
DOI: https://doi.org/10.1007/978-3-319-69892-2_387-1