Skip to main content

Incidental Findings on Neuroimaging and Normal Variants That May Mimic Disease

  • Reference work entry
  • First Online:
Clinical Neuroradiology

Abstract

Images performed for clinical or for research purposes can harbor findings that are not anticipated because they don’t fall within what was expected when planning or requesting the examination. These findings can range from variations of the norm to pathologies requiring medical intervention. Findings with potential clinical relevance, so-called incidental findings, must be anticipated responsibly, a key responsibility of the radiology profession. This chapter will first describe the prevalence of incidental findings in neuroimaging, as well as a categorization to support deciding further management. This will be followed by a description of the spectrum and clinical relevance of normal neuroanatomical variants observed on diagnostic neuroimaging studies applying various radiological techniques. To avoid unnecessary follow-up or anxiety, it is important that radiologists recognize these as “leave me alone” observations.

This publication is endorsed by: European Society of Neuroradiology (www.esnr.org).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 979.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 1,399.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Al-Holou WN, Terman SW, Kilburg C, Garton HJ, Muraszko KM, Chandler WF, Ibrahim M, Maher CO. Prevalence and natural history of pineal cysts in adults. J Neurosurg. 2011;115(6):1106–14.

    Article  Google Scholar 

  • Born CM, Meisenzahl EM, Frodl T, Pfluger T, Reiser M, Moller HJ, Leinsinger GL. The septum pellucidum and its variants. An MRI study. Eur Arch Psychiatry Clin Neurosci. 2004;254(5):295–302.

    Article  Google Scholar 

  • Bos D, Poels MM, Adams HH, Akoudad S, Cremers LG, Zonneveld HI et al. Prevalence, Clinical Management, and Natural Course of Incidental Findings on Brain MR Images: The Population-based Rotterdam Scan Study. Radiology. 2016;281(2):507–15.

    Article  Google Scholar 

  • Brinjikji W, El-Rida El-Masri A, Wald JT, Lanzino G. Prevalence of developmental venous anomalies increases with age. Stroke. 2017;48(7):1997–9.

    Article  Google Scholar 

  • Chen SS, Shao KN, Chiang JH, Chang CY, Lao CB, Lirng JF, Teng MM. Fat in the cerebral falx. Zhonghua Yi Xue Za Zhi (Taipei). 2000;63(11):804–8.

    CAS  Google Scholar 

  • Chew AP, Gupta G, Alatakis S, Schneider-Kolsky M, Stuckey SL. Hippocampal calcification prevalence at Ct: a retrospective review. Radiology. 2012;265(2):504–10.

    Article  Google Scholar 

  • Malekzadehlashkariani S, Wanke I, Rufenacht DA, San Millan D. Brain herniations into arachnoid granulations: about 68 cases in 38 patients and review of the literature. Neuroradiology. 2016;58(5):443–57.

    Article  Google Scholar 

  • Sasaki M, Sone M, Ehara S, Tamakawa Y. Hippocampal sulcus remnant: potential cause of change in signal intensity in the hippocampus. Radiology. 1993;188(3):743–6.

    Article  CAS  Google Scholar 

  • Teuber A, Sundermann B, Kugel H, Schwindt W, Heindel W, Minnerup J, Dannlowski U, Berger K, Wersching H. MR imaging of the brain in large cohort studies: feasibility report of the population- and patient-based BiDirect study. Eur Rad 2017;27(1):231–238.

    Article  Google Scholar 

  • Trzesniak C, Oliveira IR, Kempton MJ, Galvao-de Almeida A, Chagas MH, Ferrari MC, Filho AS, Zuardi AW, Prado DA, Busatto GF, McGuire PK, Hallak JE, Crippa JA. Are cavum septum pellucidum abnormalities more common in schizophrenia spectrum disorders? A systematic review and meta-analysis. Schizophr Res. 2011;125(1):1–12.

    Article  Google Scholar 

  • Wekbach S, editor. Incidental radiological findings: Springer; 2017.

    Google Scholar 

Further Reading

  • Barboriak DP, Lee L, Provenzale JM. Serial MR imaging of pineal cysts: implications for natural history and follow-up. AJR Am J Roentgenol. 2001;176:737–43.

    Article  CAS  Google Scholar 

  • Born CM, Meisenzahl EM, Frodl T, Pfluger T, Reiser M, Moller HJ, et al. The septum pellucidum and its variants. An MRI study. Eur Arch Psychiatry Clin Neurosci. 2004;254:295–302.

    Article  Google Scholar 

  • de Jong L, Thewissen L, van Loon J, Van Calenbergh F. Choroidal fissure cerebrospinal fluid-containing cysts: case series, anatomical consideration, and review of the literature. World Neurosurg. 2011;75:704–8.

    Article  Google Scholar 

  • European Society of Radiology (ESR). Good practice for radiological reporting. Guidelines from the European Society of Radiology (ESR). Insights Imaging. 2011;2(2):93–6.

    Article  Google Scholar 

  • Gross BA, Puri AS, Popp AJ, Du R. Cerebral capillary telangiectasias: a meta-analysis and review of the literature. Neurosurg Rev. 2013;36:187–93; discussion 194

    Article  Google Scholar 

  • Malekzadehlashkariani S, Wanke I, Rufenacht DA, San Millan D. Brain herniations into arachnoid granulations: about 68 cases in 38 patients and review of the literature. Neuroradiology. 2016;58:443–57.

    Article  Google Scholar 

  • Osborn AG, Preece MT. Intracranial cysts: radiologic-pathologic correlation and imaging approach. Radiology. 2006;239:650–64.

    Article  Google Scholar 

  • Ramji S, Touska P, Rich P, MacKinnon AD. Normal neuroanatomical variants that may be misinterpreted as disease entities. Clin Radiol. 2017;72:810–25.

    Article  CAS  Google Scholar 

  • Saindane AM, Lim PP, Aiken A, Chen Z, Hudgins PA. Factors determining the clinical significance of an “empty” sella turcica. AJR Am J Roentgenol. 2013;200:1125–31.

    Article  Google Scholar 

  • Vernooij MW, Ikram MA, Tanghe HL, Vincent AJ, Hofman A, Krestin GP, et al. Incidental findings on brain MRI in the general population. N Engl J Med. 2007;357:1821–8.

    Article  CAS  Google Scholar 

  • Wekbach S, editor. Incidental radiological findings: Springer; 2017. ISBN (print) 9783319425795

    Google Scholar 

  • Wolf SM, Lawrenz FP, Nelson CA, Kahn JP, Cho MK, Clayton EW, et al. Managing incidental findings in human subjects research: analysis and recommendations. J Law Med Ethics. 2008;36:219–248, 211.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Meike W. Vernooij .

Editor information

Editors and Affiliations

Section Editor information

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Vernooij, M.W., Yousry, T.A. (2019). Incidental Findings on Neuroimaging and Normal Variants That May Mimic Disease. In: Barkhof, F., Jäger, H., Thurnher, M., Rovira, À. (eds) Clinical Neuroradiology. Springer, Cham. https://doi.org/10.1007/978-3-319-68536-6_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-68536-6_19

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-68535-9

  • Online ISBN: 978-3-319-68536-6

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics