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Modulatory Role of Curcumin in miR-Mediated Regulation in Cancer and Non-cancer Diseases

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Handbook of Nutrition, Diet, and Epigenetics

Abstract

The dietary polyphenol curcumin imparts its pharmacological effects through anticancer, anti-inflammatory, antioxidant, and other mechanisms by inhibiting/modulating aberrant signaling molecules and transcription factors. MicroRNAs (miRs) modulate gene expression by regulating the degradation or translation repression of mRNA. The plethora of evidences over the past few years reflect the disruption of several fundamental regulatory mechanisms, such as carcinogenesis, cell proliferation, differentiation, programed cell death, angiogenesis, migration, invasion, etc., concerning miRs. Curcumin-mediated epigenetic alterations are the regulation of the expression of various pathogenic miRs in liver fibrosis, neurodegenerative diseases, diabetic nephropathy, ocular diseases, etc., on one hand and modulation of several tumor suppressor and oncogenic and epithelial-mesenchymal transition-suppressor microRNAs on the other hand. Based on recent evidences, miRs from miR-21, miR-26, miR-27, miR-28, miR-143, miR-199, miR-200 family, the let-7 family, etc., contribute to anomalies in both cancer and non-cancer diseases through aberrant signaling, tumor formation, and chemoresistance. In context to the significant role of miR homeostasis we summarize, in this book chapter, the findings based on in vitro and in vivo evidences on the regulatory role of curcumin on miR expression involved in cancer and non-cancer diseases.

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Abbreviations

Akt/mTOR signaling:

Protein kinase B (PKB), also known as Akt, is a serine-/threonine-specific protein kinase/mechanistic target of rapamycin signaling

AOF1/2:

Amine oxidase domain-containing protein 1/2

ARPE-19 cells:

Human retinal pigment epithelial cell line

BAG2:

BAG family molecular chaperone regulator 2

BMI1:

B lymphoma Mo-MLV insertion region 1 homolog

CAM:

Chick chorioallantoic membrane

CDKN1A:

Cyclin-dependent kinase inhibitor 1A

COL1A1:

Collagen type I alpha 1 chain

COX2:

Cyclooxygenase-2

CML xenograft:

Chronic myeloid leukemia xenograft

DNMT3b:

DNA (cytosine-5-)-methyltransferase 3 beta

Dkk-3/SMAD4:

DKK3; dickkopf WNT signaling pathway inhibitor 3/SMAD family member n°4

2D–DIGE:

Two-dimensional difference gel electrophoresis

DNMT1:

DNA (cytosine-5)-methyltransferase 1

DU145 cell:

Human Caucasian prostate cell; derived from metastatic site: brain

EMT-suppressive miRs:

Epithelial-mesenchymal transition-suppressive microRNAs

EZH2:

Enhancer of zeste 2 polycomb repressive complex 2 subunit

Erbb3:

V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

HCT116 cell:

Colon cancer cell line

HCT116-5FUR cell:

5-fluorouracil-resistant cellosaurus cell line

HL-60 cell:

Human promyelocytic leukemia cell

HAG cells:

Human astroglial cells

HSC cells:

Hematopoietic stem cells

HNG cells:

Human neuronal glial cells

HUVECs :

Human umbilical vein endothelial cells

IL-1β:

Interleukin-1 beta

K562 cell:

Chronic myelogenous leukemia cell

LAMA84 cell:

Human leukocytic cell line

Let-7 family miRs:

Lethal-7 family microRNAs

mRNA:

Messenger RNA

MMP13:

Matrix metallopeptidase 13

MAPK signaling:

Mitogen-activated protein kinase signaling

MMP-9:

Matrix metallopeptidase 9

mmu-miR:

Mus musculus microRNA

NF-κB:

Nuclear factor kappa-light-chain-enhancer of activated B cells

NKAP:

NF-kappa-B-activating protein

Oct4:

Octamer-binding transcription factor 4

PTEN:

Phosphatase and tensin homolog

PTP1B protein:

Protein-tyrosine phosphatase 1B protein

PDGFβ:

Platelet-derived growth factor beta

PKCs:

Protein kinase, catalytic subunit

PDCD4:

Programmed Cell Death 4 (Neoplastic Transformation Inhibitor)

PRCs:

Polycomb repressive complexes

PI3K:

Phosphoinositide 3-kinase

PC cells:

Prostate cancer cell

Rko cell:

Rectal carcinoma cell line

SCID mice:

Severe combined immunodeficient mice

Sox2:

SRY (sex determining region Y)-box 2

Sema6a protein:

Semaphorin 6A protein

STAT-3:

Signal transducer and activator of transcription 3

SUZ12:

SUZ12 Polycomb repressive complex 2 subunit

SW480-5FUR cell:

5-fluorouracil-resistant cellosaurus cell line

Sp proteins:

Surfactant proteins

TIMP-1:

Tissue inhibitors of metalloproteinases

TGIF:

TG-interacting factor

TGF-β:

Transforming growth factor beta

Trps1:

Transcriptional repressor GATA binding 1

VEGF:

Vascular endothelial growth factor

VEGFR2:

Vascular endothelial growth factor receptor 2

VEGFB gene:

Vascular endothelial growth factor B gene

WT1 gene:

Wilms tumor 1 gene

ZBTB10:

Zinc finger and BTB domain-containing 10

ZBTB4:

Zinc finger and BTB domain-containing 4

Y79 RB cell:

Human Caucasian retinoblastoma cell line

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Authors and Affiliations

  1. Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII-M, 700054, Kolkata, India

    Sayantani Chowdhury & Parames C. Sil

  2. Department of Chemistry, Banwarilal Bhalotia College, 713303, Ushagram Asansol, West Bengal, India

    Jyotirmoy Ghosh

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  1. Sayantani Chowdhury
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  2. Jyotirmoy Ghosh
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  3. Parames C. Sil
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Correspondence to Parames C. Sil .

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Editors and Affiliations

  1. c/o Editorial Board 978-0-387-78665 , Heidelberg, Baden-Württemberg, Germany

    Vinood Patel

  2. Kings College , London, United Kingdom

    Victor Preedy

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Chowdhury, S., Ghosh, J., Sil, P.C. (2017). Modulatory Role of Curcumin in miR-Mediated Regulation in Cancer and Non-cancer Diseases. In: Patel, V., Preedy, V. (eds) Handbook of Nutrition, Diet, and Epigenetics. Springer, Cham. https://doi.org/10.1007/978-3-319-31143-2_64-1

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  • DOI: https://doi.org/10.1007/978-3-319-31143-2_64-1

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  • Print ISBN: 978-3-319-31143-2

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