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Assessing Toxicity of Nanoparticles: In Vitro and In Vivo Assays

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Handbook of Nanoparticles

Abstract

Nanoparticles are widely utilized in the fields of medicine and industry. Accordingly, it is vital to deliberately assess the toxicity of nanoparticles in the development of nanoparticle-related products and therapeutic agents. This chapter reviews in vitro and in vivo procedures for the assessment of the toxicity of nanoparticles. As the first step, various in vitro and in vivo procedures are listed and discussed with suggestions from various researchers. Furthermore, we discuss the issues regarding the determination of toxicity assays for the evaluation of the toxicity of nanoparticles. Especially, these assays are valuable tools to investigate the differential effects of nanoparticles of various sizes and different surface modification. We expect that this chapter can be a stepping stone for further discussion about the toxicity of nanoparticles and will help researchers to evaluate the toxicity of nanoparticles efficiently.

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Acknowledgments

This study was supported by the Biosignal Analysis Technology Innovation Program (2009-0090895) of MEST/NRF, the Pioneer Research Program (2012-0009544) of MEST/NRF, Seoul National University Research Grant (800-20140542), and the Development of Characterization Techniques for the Nanomaterials Safety Project of KRCF.

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Authors and Affiliations

  1. Fight Against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea

    Dong Hyun Jo, Jin Hyoung Kim & Jeong Hun Kim

  2. Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Republic of Korea

    Dong Hyun Jo & Jeong Hun Kim

  3. Center for Nano-Bio Convergence, World Class Laboratory, Korea Research Institute of Standards and Science, Daejeon, Republic of Korea

    Tae Geol Lee

  4. Department of Ophthalmology, College of Medicine, Seoul National University, 110-744, Seoul, Republic of Korea

    Jeong Hun Kim

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  1. Dong Hyun Jo
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Correspondence to Jeong Hun Kim .

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  1. Materials Engineering, Tarbiat Modares University, Tehran, Iran

    Mahmood Aliofkhazraei

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Jo, D.H., Kim, J.H., Lee, T.G., Kim, J.H. (2015). Assessing Toxicity of Nanoparticles: In Vitro and In Vivo Assays. In: Aliofkhazraei, M. (eds) Handbook of Nanoparticles. Springer, Cham. https://doi.org/10.1007/978-3-319-13188-7_41-1

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