Abstract
The extensive applications of nanoparticles due to their unique physicochemical and biological properties have resulted in a surge in production and usage. The large-scale production and application of nanomaterials can result in their exposure to various living beings. The nanoparticle exposure can be intentional or unintentional. Many nanoparticles have a toxic response due to their increased bioactivity compared to the bulk counterpart. Hence, it is necessary to evaluate the toxicity associated with the nanoparticle. A wide spectrum of toxicity assessment tests is available and categorized into in vitro and in vivo assays. In vitro toxicity assays measure the cell’s metabolic function, membrane integrity, protein content, organelles function, and various enzymatic activities. Alternatively, in vivo toxicity assays evaluate organ-level toxicity and toxicokinetics. The selection of cell lines to perform in vitro toxicity and animal models for in vivo toxicity is critical. This chapter summarizes the various toxicity assays performed to evaluate the toxicity associated with the nanoparticle treatments.
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The authors wish to express their sincere thanks to the Director and Head, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology (Govt. of India), Trivandrum, for their support and for providing the infrastructure to carry out this work.
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Joseph, X., Akhil, Arathi, Megha, K.B., Vandana, U., Mohanan, P.V. (2023). Toxicity Assessment of Nanoparticle. In: Mohanan, P.V., Kappalli, S. (eds) Biomedical Applications and Toxicity of Nanomaterials. Springer, Singapore. https://doi.org/10.1007/978-981-19-7834-0_16
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