Abstract
Genistin is one of the most commonly found isoflavonoid glycosides. It is a 7-O-glycoside of highly biologically active isoflavonoid genistein. This glucoside is commonly produced by plant metabolism and is detected in a number of plant species, particularly in the Fabaceae family. The richest sources of genistin are soybeans and other soy-based foods. All biological properties related to isoflavonoid compounds reflect to genistin too. Although it is not that much active as glucoside, when it is metabolized it releases aglycone genistein, a compound rich in numerous beneficial pharmacological actions. One of the most important aspects for isoflavonoid use are their phytoestogenic effects. Thus, genistin is considered to exert many advantages for women health. It finds application in the treatment of postmenopausal symptoms, osteoporosis, and many types of cancer (mainly as chemoprotective agent in breast cancer treatment). Moreover, genistin exerted antioxidant, antiapoptotic, antiobesity, hepatoprotective, neuroprotective, and antimicrobial activities. This chapter focuses on summarizing all important facts regarding genistin, its biosynthesis, physicochemical properties, metabolic pathways, and bioactivities tested in vitro and in the living organisms.
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The Ministry of Science, Technological Development and Innovation of the Republic of Serbia supported the authors’ work (Agreements No. 451-03-47/2023-01/200378 and 451-03-47/2023-01/200122).
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Katanić Stanković, J.S., Mihailović, N., Srećković, N. (2023). Genistin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology. In: Xiao, J. (eds) Handbook of Dietary Flavonoids. Springer, Cham. https://doi.org/10.1007/978-3-030-94753-8_46-1
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