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Fibrin in Nerve Tissue Engineering

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Peripheral Nerve Tissue Engineering and Regeneration

Part of the book series: Reference Series in Biomedical Engineering ((TIENRE))

Abstract

This chapter will focus on the use of fibrin for peripheral nerve repair and regeneration. Important basic aspects of fibrinogen and fibrin will be summarized to elucidate the role of fibrin in physiologic processes such as hemostasis and wound healing. The pivotal role of fibrin in nerve regeneration will be discussed in the following section, as current approaches to enhance peripheral nerve regeneration are based on our momentary understanding of the physiological process of neuronal regeneration. The main focus of this work will be on the plethora of applications, which have been developed to take advantage of and modify fibrin’s intrinsic biological properties in peripheral nerve repair and regeneration. This chapter will shed light on its use as adhesive for the repair of severed nerves and to stabilize neurorrhaphy sites in order to protect sutured nerves. Nerve conduits made from fibrin will also be discussed, as well as the multitude of applications in which fibrin serves as a carrier for neurotrophic factors and other molecules to enhance nerve regeneration in vivo and in vitro. The following pages are thought to meet the needs and expectations of both clinicians, for example, plastic surgeons, orthopedic surgeons, and neurosurgeons, as well as of basic researchers, for example, biologists. Advantageous features of fibrin from a physician’s point of view will be highlighted in addition to chemical and molecular aspects which might be of special interest for basic researchers in the laboratory. In summary, we aim to give a comprehensive overview on fibrin and its application from “bench to bedside” in translational research.

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Authors and Affiliations

  1. Department of Hand, Plastic, Reconstructive and Burn Surgery, BG Trauma Center Tübingen, Eberhard Karls University, Tuebingen, Germany

    J. C. Heinzel

  2. Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Vienna, Austria

    J. C. Heinzel & D. Hercher

  3. Austrian Cluster for Tissue Regeneration, Vienna, Austria

    J. C. Heinzel & D. Hercher

  4. Department of Neurosurgery, Johannes Kepler University, Linz, Austria

    M. Gloeckel & A. Gruber

  5. Randall Centre for Cell and Molecular Biophysics, King’s College London, London, UK

    P. Heher

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  1. J. C. Heinzel
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  2. M. Gloeckel
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  3. A. Gruber
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  4. P. Heher
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  5. D. Hercher
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Correspondence to P. Heher .

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Editors and Affiliations

  1. Pharmacology, UCL School of Pharmacy, University College London Pharmacology, UCL School of Pharmacy, London, UK

    James Phillips

  2. Experimentelle u Klinische Traumatologie, Ludwig Boltzmann Institut für, Wien, Wien, Austria

    David Hercher

  3. Trauma Surgery, AUVA Unfallkrankenhaus Lorenz Böhler, Wien, Wien, Austria

    Thomas Hausner

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Heinzel, J.C., Gloeckel, M., Gruber, A., Heher, P., Hercher, D. (2021). Fibrin in Nerve Tissue Engineering. In: Phillips, J., Hercher, D., Hausner, T. (eds) Peripheral Nerve Tissue Engineering and Regeneration. Reference Series in Biomedical Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-030-06217-0_4-1

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