Skip to main content
SpringerLink
Log in

CD53

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 167 Accesses

Synonyms

CD53; Cd53; CD53 antigen; CD53 tetraspanin antigen; Cell surface glycoprotein CD53; Leukocyte surface antigen CD53; MOX44; Ox-44; OX44; Tetraspanin-25; Tspan-25; Tspan25; TSPAN25

Historical Background

CD53 is a member of the tetraspanin family of hydrophobic membrane-spanning proteins. Tetraspanins form microdomains on the cell surface that can interact with many different proteins implicated in signaling forming vesicles leading to endosome and exosome formation. CD53 has no known extracellular ligand. The specific function of CD53 has not yet been defined, but CD53 has been shown to modulate cell adhesion, migration, cell proliferation, and survival. Ligation of CD53 with antibodies protects cells from apoptosis; this effect is mediated by phosphorylation and activation of Akt, increased levels of Bcl-Xl, decreasing the amount of Bax, and reducing caspase activation. In mesangial cells, CD53 ligation stimulates the induction of DNA synthesis via the MEK-ERK pathway. CD53...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Andreu Z, Yanez-Mo M. Tetraspanins in extracellular vesicle formation and function. Front Immunol. 2014;5:442. doi:10.3389/fimmu.2014.00442.

    Article  PubMed  PubMed Central  Google Scholar 

  • Angelisova P, Vlcek C, Stefanova I, Lipoldova M, Horejsi V. The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens. Immunogenetics. 1990;32:281–5.

    Article  CAS  PubMed  Google Scholar 

  • Angelisova P, Hilgert I, Horejsi V. Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins. Immunogenetics. 1994;39:249–56.

    Article  CAS  PubMed  Google Scholar 

  • Barrena S, Almeida J, Yunta M, Lopez A, Diaz-Mediavilla J, Orfao A, et al. Discrimination of biclonal B-cell chronic lymphoproliferative neoplasias by tetraspanin antigen expression. Leukemia. 2005a;19:1708–9. doi: 10.1038/sj.leu.2403858.

    Article  CAS  PubMed  Google Scholar 

  • Barrena S, Almeida J, Yunta M, Lopez A, Fernandez-Mosteirin N, Giralt M, et al. Aberrant expression of tetraspanin molecules in B-cell chronic lymphoproliferative disorders and its correlation with normal B-cell maturation. Leukemia. 2005b;19:1376–83. doi:10.1038/sj.leu.2403822.

    Article  CAS  PubMed  Google Scholar 

  • Beinert T, Munzing S, Possinger K, Krombach F. Increased expression of the tetraspanins CD53 and CD63 on apoptotic human neutrophils. J Leukoc Biol. 2000;67:369–73.

    CAS  PubMed  Google Scholar 

  • Bosca L, Lazo PA. Induction of nitric oxide release by MRC OX-44 (anti-CD53) through a protein kinase C-dependent pathway in rat macrophages. J Exp Med. 1994;179:1119–26.

    Article  CAS  PubMed  Google Scholar 

  • Boucheix C, Rubinstein E. Tetraspanins. Cell Mol Life Sci. 2001;58:1189–205.

    Article  CAS  PubMed  Google Scholar 

  • Brackman D, Lund-Johansen F, Aarskog D. Expression of leukocyte differentiation antigens during the differentiation of HL-60 cells induced by 1,25-dihydroxyvitamin D3: comparison with the maturation of normal monocytic and granulocytic bone marrow cells. J Leukoc Biol. 1995;58:547–55.

    CAS  PubMed  Google Scholar 

  • Cao L, Yoshino T, Kawasaki N, Sakuma I, Takahashi K, Akagi T. Anti-CD53 monoclonal antibody induced LFA-1/ICAM-1-dependent and -independent lymphocyte homotypic cell aggregation. Immunobiology. 1997;197:70–81.

    Article  CAS  PubMed  Google Scholar 

  • Charrin S, Manie S, Oualid M, Billard M, Boucheix C, Rubinstein E. Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation. FEBS Lett. 2002;516:139–44.

    Article  CAS  PubMed  Google Scholar 

  • Costa-Silva B, Aiello NM, Ocean AJ, Singh S, Zhang H, Thakur BK, et al. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nat Cell Biol. 2015;17:816–26. doi:10.1038/ncb3169.

    Article  CAS  PubMed  Google Scholar 

  • Damjanovich S, Matko J, Matyus L, Szabo Jr G, Szollosi J, Pieri JC, et al. Supramolecular receptor structures in the plasma membrane of lymphocytes revealed by flow cytometric energy transfer, scanning force- and transmission electron-microscopic analyses. Cytometry. 1998;33:225–33.

    Article  CAS  PubMed  Google Scholar 

  • Deneka M, Pelchen-Matthews A, Byland R, Ruiz-Mateos E, Marsh M. In macrophages, HIV-1 assembles into an intracellular plasma membrane domain containing the tetraspanins CD81, CD9, and CD53. J Cell Biol. 2007;177:329–41.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ferrer M, Yunta M, Lazo PA. Pattern of expression of tetraspanin antigen genes in Burkitt lymphoma cell lines. Clin Exp Immunol. 1998;113:346–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hemler ME. Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain. Annu Rev Cell Dev Biol. 2003;19:397–422.

    Article  CAS  PubMed  Google Scholar 

  • Hemler ME. Tetraspanin functions and associated microdomains. Nat Rev Mol Cell Biol. 2005;6:801–11.

    Article  CAS  PubMed  Google Scholar 

  • Hemler ME. Tetraspanin proteins promote multiple cancer stages. Nat Rev Cancer. 2014;14:49–60.

    Article  CAS  PubMed  Google Scholar 

  • Hernandez-Torres J, Yunta M, Lazo PA. Differential cooperation between regulatory sequences required for human CD53 gene expression. J Biol Chem. 2001;276:35405–13. doi:10.1074/jbc.M104723200.

    Article  CAS  PubMed  Google Scholar 

  • Horejsi V, Vlcek C. Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63. FEBS Lett. 1991;288:1–4.

    Article  CAS  PubMed  Google Scholar 

  • Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, et al. Tumour exosome integrins determine organotropic metastasis. Nature. 2015;527:329–35. doi:10.1038/nature15756X.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hou CY, Lin JH, Lin SJ, Kuo WC, Lin HT. Down-regulation of CD53 expression in Epinephelus coioides under LPS, poly (I:C), and cytokine stimulation. Fish Shellfish Immunol. 2016;51:143–52. doi:10.1016/j.fsi.2015.11.032.

    Article  CAS  PubMed  Google Scholar 

  • Kyriakou D, Alexandrakis MG, Kyriakou ES, Liapi D, Kourelis TV, Mavromanolakis M, et al. Reduced CD43 expression on the neutrophils of MDS patients correlates with an activated phenotype of these cells. Int J Hematol. 2001;73:483–91.

    Article  CAS  PubMed  Google Scholar 

  • Lazo PA. Functional implications of tetraspanin proteins in cancer biology. Cancer Sci. 2007;98:1666–77. doi:10.1111/j.1349-7006.2007.00584.x.

    Article  CAS  PubMed  Google Scholar 

  • Lazo PA, Cuevas L, Gutierrez del Arroyo A, Orue E. Ligation of CD53/OX44, a tetraspan antigen, induces homotypic adhesion mediated by specific cell-cell interactions. Cell Immunol. 1997;178:132–40. doi:10.1006/cimm.1997.1139.

    Article  CAS  PubMed  Google Scholar 

  • Lee H, Bae S, Jang J, Choi BW, Park CS, Park JS, et al. CD53, a suppressor of inflammatory cytokine production, is associated with population asthma risk via the functional promoter polymorphism -1560 C>T. Biochim Biophys Acta. 2013;1830:3011–8. doi:10.1016/j.bbagen.2012.12.030.

    Article  CAS  PubMed  Google Scholar 

  • Maecker HT, Todd SC, Levy S. The tetraspanin superfamily: molecular facilitators. FASEB J. 1997;11:428–42.

    CAS  PubMed  Google Scholar 

  • Mannion BA, Berditchevski F, Kraeft SK, Chen LB, Hemler ME. Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29). J Immunol. 1996;157:2039–47.

    CAS  PubMed  Google Scholar 

  • Mansson R, Lagergren A, Hansson F, Smith E, Sigvardsson M. The CD53 and CEACAM-1 genes are genetic targets for early B cell factor. Eur J Immunol. 2007;37:1365–76.

    Article  PubMed  Google Scholar 

  • Mollinedo F, Fontan G, Barasoain I, Lazo PA. Recurrent infectious diseases in human CD53 deficiency. Clin Diagn Lab Immunol. 1997;4:229–31.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Mollinedo F, Martin-Martin B, Gajate C, Lazo PA. Physiological activation of human neutrophils down-regulates CD53 cell surface antigen. J Leukoc Biol. 1998;63:699–706.

    CAS  PubMed  Google Scholar 

  • Nichols TC, Guthridge JM, Karp DR, Molina H, Fletcher DR, Holers VM. Gamma-glutamyl transpeptidase, an ecto-enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes. Eur J Immunol. 1998;28:4123–9.

    Article  CAS  PubMed  Google Scholar 

  • Olweus J, Lund-Johansen F, Horejsi V. CD53, a protein with four membrane-spanning domains, mediates signal transduction in human monocytes and B cells. J Immunol. 1993;151:707–16.

    CAS  PubMed  Google Scholar 

  • Pedersen-Lane JH, Zurier RB, Lawrence DA. Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients. J Leukoc Biol. 2007;81:934–41. doi:10.1189/jlb.0806533.

    Article  CAS  PubMed  Google Scholar 

  • Seigneuret M, Delaguillaumie A, Lagaudriere-Gesbert C, Conjeaud H. Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion. J Biol Chem. 2001;276:40055–64.

    Article  CAS  PubMed  Google Scholar 

  • Stonehouse TJ, Woodhead VE, Herridge PS, Ashrafian H, George M, Chain BM, et al. Molecular characterization of U937-dependent T-cell co-stimulation. Immunology. 1999;96:35–47.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Szollosi J, Horejsi V, Bene L, Angelisova P, Damjanovich S. Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY. J Immunol. 1996;157:2939–46.

    CAS  PubMed  Google Scholar 

  • Tippett E, Cameron PU, Marsh M, Crowe SM. Characterization of tetraspanins CD9, CD53, CD63, and CD81 in monocytes and macrophages in HIV-1 infection. J Leukoc Biol. 2013;93:913–20. doi:10.1189/jlb.0812391.

    Article  CAS  PubMed  Google Scholar 

  • Voehringer DW, Hirschberg DL, Xiao J, Lu Q, Roederer M, Lock CB, et al. Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis. Proc Natl Acad Sci USA. 2000;97:2680–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yanez-Mo M, Barreiro O, Gordon-Alonso M, Sala-Valdes M, Sanchez-Madrid F. Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes. Trends Cell Biol. 2009;19:434–46. doi:10.1016/j.tcb.2009.06.004.

    Article  CAS  PubMed  Google Scholar 

  • Yunta M, Lazo PA. Apoptosis protection and survival signal by the CD53 tetraspanin antigen. Oncogene. 2003a;22:1219–24. doi:10.1038/sj.onc.1206183.

    Article  CAS  PubMed  Google Scholar 

  • Yunta M, Lazo PA. Tetraspanin proteins as organisers of membrane microdomains and signalling complexes. Cell Signal. 2003b;15:559–64.

    Article  CAS  PubMed  Google Scholar 

  • Yunta M, Rodriguez-Barbero A, Arevalo MA, Lopez-Novoa JM, Lazo PA. Induction of DNA synthesis by ligation of the CD53 tetraspanin antigen in primary cultures of mesangial cells. Kidney Int. 2003;63:534–42. doi:10.1046/j.1523-1755.2003.00758.x.

    Article  CAS  PubMed  Google Scholar 

  • Zhang XA, Bontrager AL, Hemler ME. Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins. J Biol Chem. 2001;276:25005–13.

    Article  CAS  PubMed  Google Scholar 

  • Zoller M. Tetraspanins: push and pull in suppressing and promoting metastasis. Nat Rev Cancer. 2009;9:40–55.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Salamanca, Instituto de Biología Molecular y Celular del Cáncer, Campus Miguel de Unamuno s/n, E-37007, Salamanca, Spain

    Pedro A. Lazo

  2. Instituto de Investigación Biomédica de Salamanca (IBSAL), Hospital Universitario de Salamanca, Salamanca, E-37007, Spain

    Pedro A. Lazo

  3. Unidad de Patología Mamaria, Unidad Funcional de Investigación en Enfermedades Crónicas, Instituto de Salud Carlos III, E-28220, Majadahonda, Madrid, Spain

    Mónica Yunta

  4. Departamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad de Santiago de Compostela, E-27002, Lugo, Spain

    Ramiro Barcia

Authors
  1. Pedro A. Lazo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mónica Yunta
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ramiro Barcia
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pedro A. Lazo .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer Science+Business Media LLC

About this entry

Cite this entry

Lazo, P.A., Yunta, M., Barcia, R. (2016). CD53. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_566-1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_566-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6438-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation