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Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins

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Abstract

Four of the tetraspans family antigens expressed in B cells, CD37, CD53, TAPA-1, and R2/C33, as well as at least two other molecules, CD19 and CD21, coprecipitate with DR antigens from mild detergent lysates of human B-cell lines and tonsillar B cells. Coprecipitation and preclearing experiments indicate the existence of large multicomponent complexes containing jointly the seven components, although some “incomplete” complexes lacking some of the components may also exist. The complexes contain only a relatively small fraction of the total cellular pool of relevant molecules. The existence of these “tetraspans-DR complexes” may be related to the previously reported antiproliferative and signaling effects of anti-bodies against most of their components.

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  1. Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 142 20 Praha 4, 1083, Víde<n 3, Czech Republic

    Pavla Angelisová, Ivan Hilgert & Václav Ho<rej<sí

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  1. Pavla Angelisová
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  2. Ivan Hilgert
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  3. Václav Ho<rej<sí
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Angelisová, P., Hilgert, I. & Ho<rej<sí, V. Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins. Immunogenetics 39, 249–256 (1994). https://doi.org/10.1007/BF00188787

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