Fig. 1

GRB7 family proteins share similar domains. GRB7 family proteins share a similar domain arrangement. An N-terminal still un-characterized region followed by a RAS-associated like (RA) domain, which is known to bind with RAS superfamily proteins. The pleckstrin homology (PH) domain binds to phospholipids and recruits proteins to the cell membrane. The Src Homology 2 (SH2) domain is a phosphotyrosine-binding domain. Between PH and SH2 domains (BPS) is a characteristic domain for GRB7 family proteins that is known to be essential for interaction with insulin receptors