Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi


  • Nuzhat N. Kabir
  • Lars Rönnstrand
  • Julhash U. Kazi
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101665-1


Historical Background

The Src Homology 2 (SH2) domain-containing adaptor proteins are a class of signal transducers downstream of growth factor receptors. The human genome encodes more than one hundred SH2 domain-containing proteins. The GRB7 family of SH2 domain-containing adaptor proteins includes three members: GRB7, GRB10, and GRB14. All three family members have the same domain structure (Fig. 1). Human GRB10 was originally identified in a yeast-two hybrid screen using the insulin receptor (IR) as bait and named as GRB-IR (Liu and Roth 1995).


Insulin Receptor Nonreceptor Tyrosine Kinase Receptor Tyrosine Kinase Signaling GRB10 Expression GRB10 Gene 
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© Springer Science+Business Media LLC 2016

Authors and Affiliations

  • Nuzhat N. Kabir
    • 1
  • Lars Rönnstrand
    • 2
  • Julhash U. Kazi
    • 1
    • 2
  1. 1.Laboratory of Computational BiochemistryKN Biomedical Research InstituteBarisalBangladesh
  2. 2.Division of Translational Cancer Research, Department of Laboratory MedicineLund UniversityLundSweden