Skip to main content
SpringerLink
Log in

GIPC

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 78 Accesses

Synonyms

C19orf64; DFNB15; DFNB72; DFNB95; GIPC; GIPC1; GIPC2; GIPC3; GLUT1CBP; IIP1; Kermit 1; Kermit 2; NIP; SEMCAP1; Synectin; TIP2

Historical Background

GIPC1 was cloned and characterized independently by diverse research groups as GAIP (RGS19)-interacting protein C-terminus [GIPC] (De Vries et al. 1998), GLUT1 (SLC2A1) C-terminal binding protein [GLUT1CBP] (Bunn et al. 1999), Insulin-like growth factor-1 receptor (IGF1R)-interacting protein 1 [IIP1] (Ligensa et al. 2001), Neuropilin 1 (NRP1)-interacting protein [NIP] (Cai and Reed 1999), Semaphorin 4C (SEMA4C) cytoplasmic domain-associated protein 1 [SEMCAP1] (Wang et al. 1999), Syndecan 4 (SDC4)-interacting protein [Synectin] (Gao et al. 2000), and Tax-interacting protein 2 [TIP2] (Rousset et al. 1998).

GIPC2 (Kirikoshi and Katoh 2002) and GIPC3 (Saitoh et al. 2002) were cloned and characterized as novel GIPC family members that are related to GIPC1. GIPC3 was then characterized as the causative gene for autosomal recessive...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Arango-Lievano M, Sensoy O, Borie A, Corbani M, Guillon G, Sokoloff P, et al. A GIPC1-palmitate switch modulates dopamine Drd3 receptor trafficking and signaling. Mol Cell Biol. 2016;36:1019–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bunn R, Jensen M, Reed B. Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton. Mol Biol Cell. 1999;10:819–32.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cai H, Reed RR. Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1. J Neurosci. 1999;19:6519–27.

    CAS  PubMed  Google Scholar 

  • Charizopoulou N, Lelli A, Schraders M, Ray K, Hildebrand MS, Ramesh A, et al. Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human. Nat Commun. 2011;2:201.

    Article  PubMed  PubMed Central  Google Scholar 

  • De Vries L, Lou X, Zhao G, Zheng B, Farquhar MG. GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP. Proc Natl Acad Sci USA. 1998;95:12340–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Duman D, Tekin M. Autosomal recessive nonsyndromic deafness genes: a review. Front Biosci. 2012;17:2213–36.

    Article  Google Scholar 

  • Favre-Bonvin A, Reynaud C, Kretz-Remy C, Jalinot P. Human papillomavirus type 18 E6 protein binds the cellular PDZ protein TIP-2/GIPC, which is involved in transforming growth factor beta signaling and triggers its degradation by the proteasome. J Virol. 2005;79:4229–37.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gao Y, Li M, Chen W, Simons M. Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration. J Cell Physiol. 2000;184:373–9.

    Article  CAS  PubMed  Google Scholar 

  • Jeanneteau F, Guillin O, Diaz J, Griffon N, Sokoloff P. GIPC recruits GAIP (RGS19) to attenuate dopamine D2 receptor signaling. Mol Biol Cell. 2004;15:4926–37.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Katoh M. Functional proteomics, human genetics and cancer biology of GIPC family members. Exp Mol Med. 2013;45:e26.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kirikoshi H, Katoh M. Molecular cloning and characterization of human GIPC2, a novel gene homologous to human GIPC1 and Xenopus Kermit. Int J Oncol. 2002;20:571–6.

    CAS  PubMed  Google Scholar 

  • La Torre A, Hoshino A, Cavanaugh C, Ware CB, Reh TA. The GIPC1-Akt pathway is required for the specification of the eye field in mouse embryonic stem cells. Stem Cells. 2015;33:2674–85.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ligensa T, Krauss S, Demuth D, Schumacher R, Camonis J, Jaques G, et al. A PDZ domain protein interacts with the C-terminal tail of the insulin-like growth factor-1 receptor but not with the insulin receptor. J Biol Chem. 2001;276:33419–27.

    Article  CAS  PubMed  Google Scholar 

  • Liu M, Horowitz A. A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype. Mol Biol Cell. 2006;17:1880–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lou X, Yano H, Lee F, Chao MV, Farquhar MG. GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways. Mol Biol Cell. 2001;12:615–27.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Muders MH, Vohra PK, Dutta SK, Wang E, Ikeda Y, Wang L, et al. Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth. Clin Cancer Res. 2009;15:4095–103.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pellet-Many C, Frankel P, Jia H, Zachary I. Neuropilins: structure, function and role in disease. Biochem J. 2008;411:211–26.

    Article  CAS  PubMed  Google Scholar 

  • Razanskas R, Sasnauskas K. Interaction of hepatitis B virus core protein with human GIPC1. Arch Virol. 2010;155:247–50.

    Article  CAS  PubMed  Google Scholar 

  • Reed BC, Cefalu C, Bellaire BH, Cardelli JA, Louis T, Salamon J, et al. GLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and myosin VI: evidence supporting an adapter function for GLUT1CBP. Mol Biol Cell. 2005;16:4183–201.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rehman AU, Gul K, Morell RJ, Lee K, Ahmed ZM, Riazuddin S, et al. Mutations of GIPC3 cause nonsyndromic hearing loss DFNB72 but not DFNB81 that also maps to chromosome 19p. Hum Genet. 2011;130:759–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P. The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins. Oncogene. 1998;16:643–54.

    Article  CAS  PubMed  Google Scholar 

  • Rudchenko S, Scanlan M, Kalantarov G, Yavelsky V, Levy C, Estabrook A, et al. A human monoclonal autoantibody to breast cancer identifies the PDZ domain containing protein GIPC1 as a novel breast cancer-associated antigen. BMC Cancer. 2008;8:248.

    Article  PubMed  PubMed Central  Google Scholar 

  • Saitoh T, Mine T, Katoh M. Molecular cloning and characterization of human GIPC3, a novel gene homologous to human GIPC1 and GIPC2. Int J Oncol. 2002;20:577–82.

    CAS  PubMed  Google Scholar 

  • Schenck A, Goto-Silva L, Collinet C, Rhinn M, Giner A, Habermann B, et al. The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development. Cell. 2008;133:486–97.

    Article  CAS  PubMed  Google Scholar 

  • Tan C, Deardorff MA, Saint-Jeannet JP, Yang J, Arzoumanian A, Klein PS. Kermit, a frizzled interacting protein, regulates frizzled 3 signaling in neural crest development. Development. 2001;128:3665–74.

    CAS  PubMed  Google Scholar 

  • Wang LH, Kalb RG, Strittmatter SM. A PDZ protein regulates the distribution of the transmembrane semaphorin. M-SemF J Biol Chem. 1999;274:14137–46.

    Article  CAS  PubMed  Google Scholar 

  • Wu J, O’Donnell M, Gitler AD, Klein PS. Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development. Development. 2006;133:3651–60.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Omics Network, National Cancer Center, 5-1-1 Tsukiji, Chuo Ward, Tokyo, 104-0045, Japan

    Masaru Katoh

Authors
  1. Masaru Katoh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Masaru Katoh .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer Science+Business Media LLC

About this entry

Cite this entry

Katoh, M. (2016). GIPC. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101607-1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101607-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6438-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation