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Interaction of hepatitis B virus core protein with human GIPC1

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Abstract

Up to now, little is known about hepatitis B virus core protein (HBc) interactions with host-cell proteins, although such interactions might be essential for virus propagation and pathogenicity. In this work, a human liver cDNA library was screened for proteins interacting with HBc. Among several HBc-interacting partners selected, it interacted most strongly with the human protein GIPC1. A common protein interaction domain, PDZ, was identified as the region that is sufficient for the interaction with HBc. The core protein has a putative C-terminal PDZ-interacting motif, and this sequence proved to be important for the interaction with GIPC1.

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Acknowledgments

This work was supported by EC project IC15-CT98-0319. The authors are grateful to drs. Helga Meisel, Detlev H. Krüger (Berlin) and Paul Pumpens (Riga) for fruitful collaboration.

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  1. Institute of Biotechnology, Graiciuno 8, 02241, Vilnius, Lithuania

    Raimundas Razanskas & Kestutis Sasnauskas

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  1. Raimundas Razanskas
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  2. Kestutis Sasnauskas
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Correspondence to Raimundas Razanskas.

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Razanskas, R., Sasnauskas, K. Interaction of hepatitis B virus core protein with human GIPC1. Arch Virol 155, 247–250 (2010). https://doi.org/10.1007/s00705-009-0561-z

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  • DOI: https://doi.org/10.1007/s00705-009-0561-z

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