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Gamma-1-Syntrophin

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Encyclopedia of Signaling Molecules

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Synonyms

SNTG1; G1SYN; Syntrophin-4, SYN4

Historical Background Putative

Gamma syntrophins were discovered by a team of scientists led by Giulio Pilusoin in the year 2000. They found that human neuronal cell contains two novel proteins which have domain organization similar to already discovered syntrophins. They named these two proteins as gamma-1-syntrophin (SNTG1) and gamma-2-syntrophin (SNTG2). Syntrophins are adapter proteins which include other three known homologous isoforms alpha-1-syntrophin (SNTA1), beta-1-syntrophin (SNTB1), and beta-2-syntrophin (SNTB2) (Froehner et al. 1997). Syntrophins are usually found associated with dystrophin family of proteins and got their name from a Greek word “syntrophos” meaning “companion” or “associate” (Froehner et al. 1997). Gamma-1-syntrophin protein is encoded by SNTG1 gene which is located on chromosome 1 in mouse and on chromosome 8 in humans. Human SNTG1 gene is composed of 19 exons and codes for a brain-specific protein of 517 amino...

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References

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Author information

Authors and Affiliations

  1. Department of Biotechnology, University of Kashmir, Srinagar, India

    Umar Mushtaq & Firdous A. Khanday

Authors
  1. Umar Mushtaq
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  2. Firdous A. Khanday
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Corresponding author

Correspondence to Firdous A. Khanday .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Mushtaq, U., Khanday, F.A. (2017). Gamma-1-Syntrophin. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101492-2

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101492-2

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  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

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Chapter history

  1. Latest

    Gamma-1-Syntrophin
    Published:
    28 March 2017

    DOI: https://doi.org/10.1007/978-1-4614-6438-9_101492-2

  2. Original

    Gamma-1-Syntrophin
    Published:
    15 November 2016

    DOI: https://doi.org/10.1007/978-1-4614-6438-9_101492-1

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