Abstract
Recent advances in semiconductor technology and microelectrode fabrication have made possible the development of implantable neural interfaces with large numbers of recording channels. Signal fidelity depends on the performance of the initial amplification stage. With many recording channels, the power efficiency of the amplifier also becomes critical. In this chapter, we discuss some of the requirements for biopotential amplifiers and the design tradeoffs. We also describe several example designs to give the reader a quantitative sense of the tradeoffs involved.
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Chae MS, Yang Z, Yuce M, Hoang L, Liu W (2009) A 128-channel 6 mW wireless neural recording IC with spike feature extraction and UWB transmitter. Neural Syst Rehabil Eng IEEE Trans 17(4):312–321. https://doi.org/10.1109/TNSRE.2009.2021607
Chi YM, Jung TP, Cauwenberghs G (2010) Dry-contact and noncontact biopotential electrodes: methodological review. IEEE Rev Biomed Eng 3:106–119
Denison T, Consoer K, Santa W, Avestruz AT, Cooley J, Kelly A (2007) A 2 μw 100 nv/rthz chopper-stabilized instrumentation amplifier for chronic measurement of neural field potentials. IEEE J Solid State Circuits 42(12):2934–2945
Enz C, Krummenacher F, Vittoz E (1995) An analytical MOS transistor model valid in all regions of operation and dedicated to low-voltage and low-current applications. Analog Integr Circuits Sig Process 8(1):83–114
Gosselin B, Ayoub A, Roy JF, Sawan M, Lepore F, Chaudhuri A, Guitton D (2009) A mixed-signal multichip neural recording interface with bandwidth reduction. IEEE Trans Biomed Circuits Syst 3(3):129–141. https://doi.org/10.1109/TBCAS.2009.2013718
Harrison R (2008) The design of integrated circuits to observe brain activity. Proc IEEE 96(7):1203–1216
Harrison RR, Charles C (2003) A low-power low-noise cmos amplifier for neural recording applications. IEEE J Solid State Circuits 38(6):958–965
Holleman J, Otis B (2007) A sub-microwatt low-noise amplifier for neural recording. In: Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th annual international conference of the IEEE, Piscataway, NJ
Jochum T, Denison T, Wolf P (2009) Integrated circuit amplifiers for multi-electrode intracortical recording. J Neural Eng 6(1) p 18
Kandel E, Schwartz J, Jessell T (2000) Principles of neural science. McGraw-Hill, New York
Kusuda Y (2010) Auto correction feedback for ripple suppression in a chopper amplifier. IEEE J Solid State Circuits 45(8):1436–1445
Levinzon FA (2008) Ultra-low-noise high-input impedance amplifier for low-frequency measurement applications. IEEE Trans Circuits Syst Part 1 Reg Papers 55(7):1815–1822
Muller R, Gambini S, Rabaey JM (2012) A 0.013, 5, dc-coupled neural signal acquisition ic with 0.5 v supply. IEEE J Solid-State Circuits 47(1):232–243
Najafi K, Wise K (1986) An implantable multielectrode array with on-chip signal processing. IEEE J Solid-State Circuits 21(6):1035–1044
Nurmikko A, Donoghue J, Hochberg L, Patterson W, Song Y-K, Bull C, Borton D, Laiwalla F, Park S, Ming Y, Aceros J (2010) Listening to brain microcircuits for interfacing with external world–progress in wireless implantable microelectronic neuroengineering devices. Proc IEEE 98(3):375–388
Polikov VS, Tresco PA, Reichert WM (2005) Response of brain tissue to chronically implanted neural electrodes. J Neurosci Methods 148(1):1–18
Qian C, Parramon J, Sanchez-Sinencio E (2011) A micropower low-noise neural recording front-end circuit for epileptic seizure detection. IEEE J Solid-State Circuits 46(6):1392–1405
Rai S, Holleman J, Pandey J, Zhang F, Otis B (2009) A 500 μW neural tag with 2 μVrms AFE and frequency-multiplying MICS/ISM FSK transmitter. In: Solid-state circuits conference – digest of technical papers, 2009. ISSCC 2009. IEEE International, pp 212–213, 213a
Razavi B (2000) Design of analog CMOS integrated circuits. Tata McGraw-Hill Edition, Boston
Steyaert M, Sansen W (1987) A micropower low-noise monolithic instrumentation amplifier for medical purposes. IEEE J Solid State Circuits 22(6):1163–1168
Wattanapanitch W, Fee M, Sarpeshkar R (2007) An energy-efficient micropower neural recording amplifier. IEEE Trans Biomed Circuits Syst 1(2):136–147
Wu H, Xu YP (2006) A 1V 2.3μW biomedical signal acquisition IC. In: Solid-state circuits conference, 2006. ISSCC 2006. Digest of technical papers. IEEE International, pp 119–128
Wu R, Makinwa KA, Huijsing JH (2009) A chopper current-feedback instrumentation amplifier with a 1 mhz 1/f noise corner and an ac-coupled ripple reduction loop. IEEE J Solid State Circuits 44(12):3232–3243
Yin M, Ghovanloo M (2007) A low-noise preamplifier with adjustable gain and bandwidth for biopotential recording applications. IEEE Int Symp Circuits Syst 42(9):1865–1872
Zhang F, Holleman J, Otis BP (2012) Design of ultra-low power biopotential amplifiers for biosignal acquisition applications. IEEE Trans Biomed Circuits Syst 6(4):344–355
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Zhang, F., Yang, T., Holleman, J., Otis, B. (2022). Electrical Biosensors: Biopotential Amplifiers. In: Sawan, M. (eds) Handbook of Biochips. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3447-4_24
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DOI: https://doi.org/10.1007/978-1-4614-3447-4_24
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