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Precancerous Lesions of the Cervix

  • Reference work entry
Blaustein’s Pathology of the Female Genital Tract

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Abstract

The histopathological classification of a disease should reflect both current concepts of its pathogenesis as well as its clinical behavior. Over the last 50 years, our understanding of the pathobiology and behavior of cervical cancer precursors has evolved considerably. As a result, the terminology used to classify preinvasive lesions of the cervix has frequently changed. Although these changes in nomenclature and the resulting lack of a uniform terminology have been an ongoing source of confusion to both gynecologists and pathologists, each change has actually reduced the number of specific pathological categories and has made clinical decision making more straightforward.

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References

  1. Abdul-Karim FW, Fu YS, Reagan JW et al (1982) Morphometric study of intraepithelial neoplasia of the uterine cervix. Obstet Gynecol 60:210–214

    PubMed  CAS  Google Scholar 

  2. Alvarez RD, Wright TC (2007) Effective cervical neoplasia detection with a novel optical detection system: a randomized trial. Gynecol Oncol 104(2):281–289

    Article  PubMed  CAS  Google Scholar 

  3. Anciaux D, Lawrence WD, Gregoire L (1997) Glandular lesions of the uterine cervix: prognostic implications of human papillomavirus status. Int J Gynecol Pathol 16:103–110

    Article  PubMed  CAS  Google Scholar 

  4. Andersen ES, Arffmann E (1989) Adenocarcinoma in situ of the uterine cervix: a clinico-pathologic study of 36 cases. Gynecol Oncol 35:1–7

    Article  PubMed  CAS  Google Scholar 

  5. Anonymous (2001) SEER Program – National Cancer Institute, USA. http://www-seer.ims.nci.nih.gov/ScientificSystems/. Retrieved 20 Mar, 2003, 2009

    Google Scholar 

  6. Appleby P, Beral V, Berrington de Gonzalez A et al (2007) Cervical cancer and hormonal contraceptives: collaborative reanalysis of individual data for 16,573 women with cervical cancer and 35,509 women without cervical cancer from 24 epidemiological studies. Lancet 370(9599):1609–1621

    Article  PubMed  CAS  Google Scholar 

  7. Arbyn M, Sasieni P, Meijer CJ et al (2006) Chapter 9: Clinical applications of HPV testing: a summary of meta-analyses. Vaccine 24(Suppl 3):S78–S89

    Article  Google Scholar 

  8. ASCUS-LSIL Traige Study (ALTS) Group (2003) A randomized trial on the management of low-grade squamous intraepithelial lesion cytology interpretations. Am J Obstet Gynecol 188(6):1393–1400

    Google Scholar 

  9. ASCUS-LSIL Traige Study (ALTS) Group (2003) Results of a randomized trial on the management of cytology interpretations of atypical squamous cells of undetermined significance. Am J Obstet Gynecol 188(6):1383–1392

    Google Scholar 

  10. Baker AC, Eltoum I, Curry RO et al (2006) Mucinous expression in benign and neoplastic glandular lesions of the uterine cervix. Arch Pathol Lab Med 130(10):1510–1515

    PubMed  Google Scholar 

  11. Bandyopadhyay S, Austin RM, Dabbs D et al (2008) Adjunctive human papillomavirus DNA testing is a useful option in some clinical settings for disease risk assessment and triage of females with ASC-H Papanicolaou test results. Arch Pathol Lab Med 132(12):1874–1881

    PubMed  Google Scholar 

  12. Benard VB, Lee NC, Piper M et al (2001) Race-specific results of Papanicolaou testing and the rate of cervical neoplasia in the National Breast and Cervical Cancer Early Detection Program, 1991–1998 (United States). Cancer Causes Control 12(1):61–68

    Article  PubMed  CAS  Google Scholar 

  13. Bergeron C, Ferenczy A, Shah K et al (1987) Multicentric human papillomavirus infections of the female genital tract. Correlation of viral types with abnormal mitotic figures, colposcopic presentation, and location. Obstet Gynecol 69:736–742

    PubMed  CAS  Google Scholar 

  14. Bernard H-U, Chan S-Y, Delius H (1994) Evolution of papillomaviruses. Curr Top Microbiol Immunol 186:33–54

    Article  PubMed  CAS  Google Scholar 

  15. Bertrand M, Lickrish GM, Colgan TJ (1987) The anatomic distribution of cervical adenocarcinoma in situ: implications for treatment. Am J Obstet Gynecol 157:21–25

    PubMed  CAS  Google Scholar 

  16. Boardman LA, Stanko C, Weitzen S et al (2005) Atypical squamous cells of undetermined significance: human papillomavirus testing in adolescents. Obstet Gynecol 105(4):741–746

    Article  PubMed  Google Scholar 

  17. Bocking A, Nguyen VQ (2004) Diagnostic and prognostic use of DNA image cytometry in cervical squamous intraepithelial lesions and invasive carcinoma. Cancer 102(1):41–54

    Article  PubMed  CAS  Google Scholar 

  18. Boddington MM, Spriggs AI, Cowdell RH (1976) Adenocarcinoma of the uterine cervix: cytological evidence of a long preclinical evolution. Br J Obstet Gynecol 83:900–903

    Article  CAS  Google Scholar 

  19. Bollmann R, Mehes G, Speich N et al (2005) Aberrant, highly hyperdiploid cells in human papillomavirus-positive, abnormal cytologic samples are associated with progressive lesions of the uterine cervix. Cancer 105(2):96–100

    Article  PubMed  Google Scholar 

  20. Bollmann R, Mehes G, Torka R et al (2003) Human papillomavirus typing and DNA ploidy determination of squamous intraepithelial lesions in liquid-based cytologic samples. Cancer 99(1):57–62

    Article  PubMed  Google Scholar 

  21. Boon ME, Baak JPA, Kurver PJH et al (1981) Adenocarcinoma in situ of the cervix: an underdiagnosed lesion. Cancer 48:768–773

    Article  PubMed  CAS  Google Scholar 

  22. Bosch FX, de Sanjose S (2007) The epidemiology of human papillomavirus infection and cervical cancer. Dis Markers 23(4):213–227

    PubMed  Google Scholar 

  23. Bousfield L, Pacey F, Young Q et al (1980) Expanded cytologic criteria for the diagnosis of adenocarcinoma in situ of the cervix and related lesions. Acta Cytol 24(4):283–296

    PubMed  CAS  Google Scholar 

  24. Broders AC (1932) Carcinoma in situ contrasted with benign penetrating epithelium. JAMA 99:1670–1674

    Article  Google Scholar 

  25. Brown DR, Shew ML, Qadadri B et al (2005) A longitudinal study of genital human papillomavirus infection in a cohort of closely followed adolescent women. J Infect Dis 191(2):182–192

    Article  PubMed  Google Scholar 

  26. Brown LJR, Wells M (1986) Cervical glandular atypia associated with squamous intraepithelial neoplasia: a premalignant lesion? J Clin Pathol 39:22–28

    Article  PubMed  CAS  Google Scholar 

  27. Burchell AN, Winer RL, de Sanjose S et al (2006) Chapter 6: Epidemiology and transmission dynamics of genital HPV infection. Vaccine 24(Suppl 3):S52–S61

    Article  Google Scholar 

  28. Burghardt E (1991) Colposcopy-cervical pathology. Thieme Medical, New York

    Google Scholar 

  29. Butterworth CEJ, Hatch KD, Macaluso M et al (1992) Folate deficiency and cervical dysplasia. JAMA 267:528–533

    Article  PubMed  Google Scholar 

  30. Cameron RI, Maxwell P, Jenkins D et al (2002) Immunohistochemical staining with MIB1, bcl2 and p16 assists in the distinction of cervical glandular intraepithelial neoplasia from tubo-endometrial metaplasia, endometriosis and microglandular hyperplasia. Histopathology 41(4):313–321

    Article  PubMed  CAS  Google Scholar 

  31. Castle PE, Giuliano AR (2003) Chapter 4: Genital tract infections, cervical inflammation, and antioxidant nutrients – assessing their roles as human papillomavirus cofactors. J Natl Cancer Inst Monogr (31):29–34

    Google Scholar 

  32. Castle PE, Schiffman M, Wheeler CM et al (2009) Evidence for frequent regression of cervical intraepithelial neoplasia-grade 2. Obstet Gynecol 113(1):18–25

    PubMed  Google Scholar 

  33. Castle PE, Stoler MH, Solomon D et al (2007) The relationship of community biopsy-diagnosed cervical intraepithelial neoplasia grade 2 to the quality control pathology-reviewed diagnoses: an ALTS report. Am J Clin Pathol 127(5):805–815

    Article  PubMed  Google Scholar 

  34. Castle PE, Wacholder S, Sherman ME et al (2002) Absolute risk of a subsequent abnormal pap among oncogenic human papillomavirus DNA-positive, cytologically negative women. Cancer 95(10):2145–2151

    Article  PubMed  Google Scholar 

  35. Chung TK, Cheung TH, Lo WK et al (2000) Loss of heterozygosity at the short arm of chromosome 3 in microdissected cervical intraepithelial neoplasia. Cancer Lett 154(2):189–194

    Article  PubMed  CAS  Google Scholar 

  36. Clifford G, Franceschi S, Diaz M et al (2006) Chapter 3: HPV type-distribution in women with and without cervical neoplastic diseases. Vaccine 24(Suppl 3):S26–S34

    Article  Google Scholar 

  37. Clifford GM, Rana RK, Franceschi S et al (2005) Human papillomavirus genotype distribution in low-grade cervical lesions: comparison by geographic region and with cervical cancer. Cancer Epidemiol Biomarkers Prev 14(5):1157–1164

    Article  PubMed  Google Scholar 

  38. Colgan TJ, Lickrish GM (1990) The topography and invasive potential of cervical adenocarcinoma in situ, with and without associated squamous dysplasia. Gynecol Oncol 36:246–249

    Article  PubMed  CAS  Google Scholar 

  39. Confortini M, Bondi A, Cariaggi MP et al (2007) Interlaboratory reproducibility of liquid-based equivocal cervical cytology within a randomized controlled trial framework. Diagn Cytopathol 35(9):541–544

    Article  PubMed  CAS  Google Scholar 

  40. Confortini M, Carozzi F, Dalla Palma P et al (2003) Interlaboratory reproducibility of atypical squamous cells of undetermined significance report: a national survey. Cytopathology 14(5):263–268

    Article  PubMed  CAS  Google Scholar 

  41. Crocker J, Fox H, Langley FA (1968) Consistency in the histological diagnosis of epithelial abnormalities of the cervix uteri. J Clin Pathol 21:67–70

    Article  Google Scholar 

  42. Crum CP, Egawa K, Fu YS et al (1983) Atypical immature metaplasia (AIM): a subset of human papillomavirus infection of the cervix. Cancer 51:2214–2219

    Article  PubMed  CAS  Google Scholar 

  43. Crum CP, Egawa K, Levine RU et al (1983) Human papillomavirus infection (condyloma) of the cervix and cervical intraepithelial neoplasia: a histological and statistical analysis. Gynecol Oncol 15:88

    Article  PubMed  CAS  Google Scholar 

  44. Cullen TS (1900) Cancer of the uterus. Appleton, New York

    Google Scholar 

  45. Cullimore JE, Luesley DM, Rollason TP et al (1992) A prospective study of conization of the cervix in the management of cervical intraepithelial glandular neoplasia (CIGN) – a preliminary report. Br J Obstet Gynecol 99:314–318

    Article  CAS  Google Scholar 

  46. Datta SD, Koutsky LA, Ratelle S et al (2008) Human papillomavirus infection and cervical cytology in women screened for cervical cancer in the United States, 2003–2005. Ann Intern Med 148(7):493–500

    PubMed  Google Scholar 

  47. Davey DD, Neal MH, Wilbur DC et al (2004) Bethesda 2001 implementation and reporting rates: 2003 practices of participants in the College of American Pathologists Interlaboratory Comparison Program in Cervicovaginal Cytology. Arch Pathol Lab Med 128(11):1224–1229

    PubMed  Google Scholar 

  48. de Araujo Souza PS, Maciag PC, Ribeiro KB et al (2008) Interaction between polymorphisms of the human leukocyte antigen and HPV-16 variants on the risk of invasive cervical cancer. BMC Cancer 8:246

    Article  PubMed  CAS  Google Scholar 

  49. de Sanjose S, Diaz M, Castellsague X et al (2007) Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect Dis 7(7):453–459

    Article  PubMed  Google Scholar 

  50. de Villiers EM, Fauquet C, Broker TR et al (2004) Classification of papillomaviruses. Virology 324(1):17–27

    Article  PubMed  CAS  Google Scholar 

  51. Denehy TR, Gregori CA, Breen JL (1997) Endocervical curettage, cone margins, and residual adenocarcinoma in situ of the cervix. Obstet Gynecol 90(1):1–6

    Article  PubMed  CAS  Google Scholar 

  52. Doorbar J (2006) Molecular biology of human papillomavirus infection and cervical cancer. Clin Sci (Lond) 110(5):525–541

    Article  CAS  Google Scholar 

  53. Driggers RW, Zahn CM (2008) To ECC or not to ECC: the question remains. Obstet Gynecol Clin North Am 35(4):583–597; viii

    Google Scholar 

  54. Duby JM, DiFurio MJ (2009) Implementation of the ThinPrep Imaging System in a tertiary military medical center. Cancer Cytopathol 117(4):264–270

    Article  Google Scholar 

  55. Duggan MA, Benoit JL, McGregor SE et al (1994) Adenocarcinoma in situ of the endocervix: Human papillomavirus determination by dot blot hybridization and polymerase chain reaction amplification. Int J Gynecol Pathol 13(2):143–149

    Article  PubMed  CAS  Google Scholar 

  56. Dunn TS, Burke M, Shwayder J (2003) A “see and treat” management for high-grade squamous intraepithelial lesion pap smears. J Low Genit Tract Dis 7(2):104–106

    Article  PubMed  Google Scholar 

  57. Duska LR (2009) Can we improve the detection of glandular cervical lesions: the role and limitations of the Pap smear diagnosis atypical glandular cells (AGC). Gynecol Oncol 114(3):381–382

    Article  PubMed  Google Scholar 

  58. Evans MF, Adamson CS, Papillo JL et al (2006) Distribution of human papillomavirus types in ThinPrep Papanicolaou tests classified according to the Bethesda 2001 terminology and correlations with patient age and biopsy outcomes. Cancer 106(5):1054–1064

    Article  PubMed  Google Scholar 

  59. Fordyce EJ, Wang Z, Kahn AR et al (2000) Risk of cancer among women with AIDS in New York City. AIDS Public Policy J 15(3–4):95–104

    PubMed  CAS  Google Scholar 

  60. Franquemont DW, Ward BE, Anderson WA et al (1989) Prediction of “high-risk” cervical papillomavirus infection by biopsy morphology. Am J Clin Pathol 92(5):577–582

    PubMed  CAS  Google Scholar 

  61. Friedell GH, McKay DG (1953) Adenocarcinoma in situ of endocervix. Cancer 6:887–897

    Article  PubMed  CAS  Google Scholar 

  62. Fu YS, Braun L, Shah KV et al (1983) Histologic, nuclear DNA, and human papillomavirus studies of cervical condylomas. Cancer 52:1705–1711

    Article  PubMed  CAS  Google Scholar 

  63. Fu YS, Huang I, Beaudenon S et al (1988) Correlative study of human papillomavirus DNA, histopathology and morphometry in cervical condyloma and intraepithelial neoplasia. Int J Gynecol Pathol 7:297–307

    Article  PubMed  CAS  Google Scholar 

  64. Fu YS, Reagan JW (2002) Pathology of the uterine cervix, vagina, and vulva. WB Saunders, Philadelphia

    Google Scholar 

  65. Fu YS, Reagan JW, Richart RM (1983) Precursors of cervical cancer. Cancer Surv 2:359–382

    Google Scholar 

  66. Gage JC, Hanson VW, Abbey K et al (2006) Number of cervical biopsies and sensitivity of colposcopy. Obstet Gynecol 108(2):264–272

    Article  PubMed  Google Scholar 

  67. Garcia-Closas R, Castellsague X, Bosch X et al (2005) The role of diet and nutrition in cervical carcinogenesis: a review of recent evidence. Int J Cancer 117(4):629–637

    Article  PubMed  CAS  Google Scholar 

  68. Gatscha RM, Abadi M, Babore S et al (2001) Smears diagnosed as ASCUS: interobserver variation and follow-up. Diagn Cytopathol 25(2):138–140

    Article  PubMed  CAS  Google Scholar 

  69. Genest DR, Stein L, Cibas E et al (1993) A binary (Bethesda) system for classifying cervical cancer precursors: criteria, reproducibility, and viral correlates. Hum Pathol 24(7):730–736

    Article  PubMed  CAS  Google Scholar 

  70. Geng L, Connolly DC, Isacson C et al (1999) Atypical immature metaplasia (AIM) of the cervix: is it related to high-grade squamous intraepithelial lesion (HSIL)? Hum Pathol 30(3):345–351

    Article  PubMed  CAS  Google Scholar 

  71. Gloor E, Hurlimann J (1986) Cervical intraepithelial glandular neoplasia (adenocarcinoma in situ and glandular dysplasia). A correlative study of 23 cases with histologic grading, histochemical analysis of mucins and immunohistochemical determination of the affinity for four lectins. Cancer 58:1272–1280

    Article  PubMed  CAS  Google Scholar 

  72. Goldie SJ, Kim JJ, Wright TC (2004) Cost-effectiveness of human papillomavirus DNA testing for cervical cancer screening in women aged 30 years or more. Obstet Gynecol 103(4):619–631

    Article  PubMed  Google Scholar 

  73. Guido RS, Jeronimo J, Schiffman M et al (2005) The distribution of neoplasia arising on the cervix: results from the ALTS trial. Am J Obstet Gynecol 193(4):1331–1337

    Article  PubMed  Google Scholar 

  74. Hanselaar AG, Vooijs GP, Oud PS et al (1988) DNA ploidy patterns in cervical intraepithelial neoplasia grade III, with and without synchronous invasive squamous cell carcinoma: Measurements in nuclei isolated from paraffin-embedded tissue. Cancer 62:2537–2545

    Article  PubMed  CAS  Google Scholar 

  75. Hariri J, Oster A (2007) The negative predictive value of p16INK4a to assess the outcome of cervical intraepithelial neoplasia 1 in the uterine cervix. Int J Gynecol Pathol 26(3):223–228

    Article  PubMed  Google Scholar 

  76. Helper TK, Dockerty MB, Randall LM (1952) Primary adenocarcinoma of the cervix. Am J Obstet Gynecol 63:800–808

    Google Scholar 

  77. Higgins GD, Phillips GE, Smith LA et al (1992) High prevalence of human papillomavirus transcripts in all grades of cervical intraepithelial glandular neoplasia. Cancer 70:136–146

    Article  PubMed  CAS  Google Scholar 

  78. Ho GY, Studentsov YY, Bierman R et al (2004) Natural history of human papillomavirus type 16 virus-like particle antibodies in young women. Cancer Epidemiol Biomarkers Prev 13(1):110–116

    Article  PubMed  CAS  Google Scholar 

  79. Hoffman MS, Sterghos S Jr, Gordy LW et al (1993) Evaluation of the cervical canal with the endocervical brush. Obstet Gynecol 82(4 Pt 1):573–577

    PubMed  CAS  Google Scholar 

  80. Holowaty P, Miller AB, Rohan T et al (1999) Natural history of dysplasia of the uterine cervix. J Natl Cancer Inst 91(3):252–258

    Article  PubMed  CAS  Google Scholar 

  81. Hopkins MP, Roberts JA, Schmidt RW (1988) Cervical adenocarcinoma in situ. Obstet Gynecol 71:842–844

    PubMed  CAS  Google Scholar 

  82. Hurlimann J, Gloor E (1984) Adenocarcinoma in situ and invasive adenocarcinoma of the uterine cervix. An immunohistologic study with antibodies specific for several epithelial markers. Cancer 54(1):103–109

    Article  PubMed  CAS  Google Scholar 

  83. IARC (2007) Human Papillomaviruses. IARC, Lyon

    Google Scholar 

  84. Insinga RP, Glass AG, Rush BB (2004) Diagnoses and outcomes in cervical cancer screening: a population-based study. Am J Obstet Gynecol 191(1):105–113

    Article  PubMed  Google Scholar 

  85. Ioffe OB, Sagae S, Moritani S et al (2003) Symposium part 3: Should pathologists diagnose endocervical preneoplastic lesions “less than” adenocarcinoma in situ?: point. Int J Gynecol Pathol 22(1):18–21

    Article  PubMed  Google Scholar 

  86. Isacson C, Kessis TD, Hedrick L et al (1996) Both cell proliferation and apoptosis increase with lesion grade in cervical neoplasia but do not correlate with human papillomavirus type. Cancer Res 56(4):669–674

    PubMed  CAS  Google Scholar 

  87. Ismail SM, Colelough AB, Dinnen JS et al (1989) Observer variation in histopathological diagnosis and grading of cervical intraepithelial neoplasia. BMJ 298:707–710

    Article  PubMed  CAS  Google Scholar 

  88. Jakobsen A, Kristensen PB, Poulsen HK (1983) Flow cytometric classification of biopsy specimens from cervical intraepithelial neoplasia. Cytometry 4:166–169

    Article  PubMed  CAS  Google Scholar 

  89. Jaworski RC, Pacey NR, Greenberg ML et al (1988) The histologic diagnosis of adenocarcinoma in situ and related lesions of the cervix uteri. Adenocarcinoma in situ. Cancer 61:1171–1181

    Article  PubMed  CAS  Google Scholar 

  90. Jenson AB, Rosenthal JD, Olson C et al (1980) Immunologic relatedness of papillomavirus from different species. J Natl Cancer Instit 64:495–500

    CAS  Google Scholar 

  91. Johnson LD (1969) The histopathological approach to early cervical neoplasia. Obstet Gynecol Surv 24:735–767

    Article  PubMed  CAS  Google Scholar 

  92. Jones BA, Davey DD (2000) Quality management in gynecologic cytology using interlaboratory comparison. Arch Pathol Lab Med 124(5):672–681

    PubMed  CAS  Google Scholar 

  93. Jones BA, Novis DA (1996) Cervical biopsy-cytology correlation. A College of American Pathologists Q-Probes study of 22,439 correlations in 348 laboratories. Arch Pathol Lab Med 120(6):523–531

    PubMed  CAS  Google Scholar 

  94. Jones BA, Novis DA (2000) Follow-up of abnormal gynecologic cytology: a college of American pathologists Q-probes study of 16132 cases from 306 laboratories. Arch Pathol Lab Med 124(5):665–671

    PubMed  CAS  Google Scholar 

  95. Kashimura M, Shinohara M, Oikawa K et al (1990) An adenocarcinoma in situ of the uterine cervix that developed into invasive adenocarcinoma after 5 years. Gynecol Oncol 36:128–133

    Article  PubMed  CAS  Google Scholar 

  96. Keating JT, Cviko A, Riethdorf S et al (2001) Ki-67, cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia. Am J Surg Pathol 25(7):884–891

    Article  PubMed  CAS  Google Scholar 

  97. Kim TJ, Kim HS, Park CT et al (1999) Clinical evaluation of follow-up methods and results of atypical glandular cells of undetermined significance (AGUS) detected on cervicovaginal Pap smears. Gynecol Oncol 73(2):292–298

    Article  PubMed  CAS  Google Scholar 

  98. Kim JJ, Wright TC, Goldie SJ (2002) Cost-effectiveness of alternative triage strategies for atypical squamous cells of undetermined significance. JAMA 287(18):2382–2390

    Article  PubMed  Google Scholar 

  99. Kinney WK, Manos MM, Hurley LB et al (1998) Where’s the high-grade cervical neoplasia? The importance of minimally abnormal Papanicolaou diagnoses. Obstet Gynecol 91(6):973–976

    Article  PubMed  CAS  Google Scholar 

  100. Kirkland JA (1963) Atypical epithelial changes in the uterine cervix. J Clin Pathol 16:150–154

    Article  PubMed  CAS  Google Scholar 

  101. Klaes R, Friedrich T, Spitkovsky D et al (2001) Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer 92(2):276–284

    Article  PubMed  CAS  Google Scholar 

  102. Kolstad P, Klem V (1976) Long-term followup of 1121 cases of carcinoma in situ. Obstet Gynecol 48(2):125–129

    PubMed  CAS  Google Scholar 

  103. Koss LG (1978) Dysplasia. A real concept or a misnomer? Obstet Gynecol 51:374

    Article  PubMed  CAS  Google Scholar 

  104. Koss LG, Stewart FW, Foote FW et al (1963) Some histological aspects of behavior of epidermoid carcinoma in situ and related lesions of the uterine cervix. Cancer 16(9):1160–1211

    Article  PubMed  CAS  Google Scholar 

  105. Kudo R, Sagai S, Hayakawa O et al (1991) Morphology of adenocarcinoma in situ and microinvasive adenocarcinoma of the uterine cervix. Acta Cytol 35:109–116

    PubMed  CAS  Google Scholar 

  106. Kulasingam SL, Kim JJ, Lawrence WF et al (2006) Cost-effectiveness analysis based on the atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesion Triage Study (ALTS). J Natl Cancer Inst 98(2):92–100

    Article  PubMed  Google Scholar 

  107. Kurman RJ, Ronnett BM, Sherman ME et al (2009) Tumors of the cervix, vagina and vulva. American Registry of Pathology in conjunction with Armed Forces Institute of Pathology, Washington, DC

    Google Scholar 

  108. Larson AA, Kern S, Curtiss S et al (1997) High resolution analysis of chromosome 3p alterations in cervical carcinoma. Cancer Res 57:4082–4090

    PubMed  CAS  Google Scholar 

  109. Leary J, Jaworski R, Houghton R (1991) In-situ hybridization using biotinylated DNA probes to human papillomavirus in adenocarcinoma in-situ and endocervical glandular dysplasia of the uterine cervix. Pathology 23:85–89

    Article  PubMed  CAS  Google Scholar 

  110. Lee KR (2003) Symposium part 4: Should pathologists diagnose endocervical preneoplastic lesions “less than” adenocarcinoma in situ?: counterpoint. Int J Gynecol Pathol 22(1):22–24

    Article  PubMed  Google Scholar 

  111. Lee KR, Sun D, Crum CP (2000) Endocervical intraepithelial glandular atypia (dysplasia): a histopathologic, human papillomavirus, and MIB-1 analysis of 25 cases. Hum Pathol 31(6):656–664

    Article  PubMed  CAS  Google Scholar 

  112. Liman AK, Giampoli EJ, Bonfiglio TA (2005) Should women with atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion, receive reflex human papillomavirus-DNA testing? Cancer 105(6):457–460

    Article  PubMed  Google Scholar 

  113. Lonky NM, Felix JC, Naidu YM et al (2003) Triage of atypical squamous cells of undetermined significance with hybrid capture II: colposcopy and histologic human papillomavirus correlation. Obstet Gynecol 101(3):481–489

    Article  PubMed  Google Scholar 

  114. Lonky NM, Sadeghi M, Tsadik GW et al (1999) The clinical significance of the poor correlation of cervical dysplasia and cervical malignancy with referral cytologic results. Am J Obstet Gynecol 181(3):560–566

    Article  PubMed  CAS  Google Scholar 

  115. Luesley DM, Jordan JA, Woodman CBJ et al (1987) A retrospective review of adenocarcinoma-in-situ and glandular atypia of the uterine cervix. Br J Obstet Gynaecol 94:699–703

    Article  PubMed  CAS  Google Scholar 

  116. Luff RD (1992) The Bethesda System for reporting cervical/vaginal cytologic diagnoses: report of the 1991 Bethesda workshop. The Bethesda System Editorial Committee. Hum Pathol 23(7):719–721

    Article  PubMed  CAS  Google Scholar 

  117. Maiman M (1998) Management of cervical neoplasia in human immunodeficiency virus-infected women. J Natl Cancer Instit 23:43–49

    Google Scholar 

  118. Manos MM, Kinney WK, Hurley LB et al (1999) Identifying women with cervical neoplasia: using human papillomavirus DNA testing for equivocal Papanicolaou results. JAMA 281(17):1605–1610

    Article  PubMed  CAS  Google Scholar 

  119. Marques T, Andrade LA, Vassallo J (1996) Endocervical tubal metaplasia and adenocarcinoma in situ: role of immunohistochemistry for carcinoembryonic antigen and vimentin in differential diagnosis. Histopathology 28(6):549–550

    Article  PubMed  CAS  Google Scholar 

  120. Massad LS (2006) More is more: improving the sensitivity of colposcopy. Obstet Gynecol 108(2):246–247

    Article  PubMed  Google Scholar 

  121. Massad LS, Collins YC, Meyer PM (2001) Biopsy correlates of abnormal cervical cytology classified using the Bethesda system. Gynecol Oncol 82(3):516–522

    Article  PubMed  CAS  Google Scholar 

  122. McCann MF, Irwin DE, Walton LA et al (1992) Nicotine and cotinine in the cervical mucus of smokers, passive smokers, and nonsmokers. Cancer Epidemiol Biomarkers Prev 1:125–129

    PubMed  CAS  Google Scholar 

  123. McCluggage WG (2007) Immunohistochemistry as a diagnostic aid in cervical pathology. Pathology 39(1):97–111

    Article  PubMed  CAS  Google Scholar 

  124. McCluggage WG, Maxwell P, McBride HA et al (1995) Monoclonal antibodies Ki-67 and MIB1 in the distinction of tuboendometrial metaplasia from endocervical adenocarcinoma and adenocarcinoma in situ in formalin-fixed material. Int J Gynecol Pathol 14(3):209–216

    Article  PubMed  CAS  Google Scholar 

  125. McCredie MR, Sharples KJ, Paul C et al (2008) Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study. Lancet Oncol 9(5):425–434

    Article  PubMed  Google Scholar 

  126. Melnikow J, Nuovo J, Willan AR et al (1998) Natural history of cervical squamous intraepithelial lesions: a meta-analysis. Obstet Gynecol 92(4 Pt 2):727–735

    Article  PubMed  CAS  Google Scholar 

  127. Mitchell H, Hocking J, Saville M (2004) Cervical cytology screening history of women diagnosed with adenocarcinoma in situ of the cervix: a case-control study. Acta Cytol 48(5):595–600

    Article  PubMed  Google Scholar 

  128. Mitchell H, Medley G, Gordon I et al (1995) Cervical cytology reported as negative and risk of adenocarcinoma of the cervix: no strong evidence of benefit. Br J Cancer 71(4):894–897

    Article  PubMed  CAS  Google Scholar 

  129. Mitchell MF, Tortolero-Luna G, Wright T et al (1996) Cervical human papillomavirus infection and intraepithelial neoplasia: a review. J Natl Cancer Inst Monogr 21:17–25

    PubMed  Google Scholar 

  130. Mittal KR, Chan W, Demopoulos RL (1990) Sensitivity and specificity of various morphological features of cervical condylomas. Arch Pathol Lab Med 114:1038–1041

    PubMed  CAS  Google Scholar 

  131. Moscicki AB, Hills N, Shiboski S et al (2001) Risks for incident human papillomavirus infection and low-grade squamous intraepithelial lesion development in young females. JAMA 285:2995–3002

    Article  PubMed  CAS  Google Scholar 

  132. Moscicki AB, Schiffman M, Kjaer S et al (2006) Chapter 5: Updating the natural history of HPV and anogenital cancer. Vaccine 24(Suppl 3):S42–S51

    Article  Google Scholar 

  133. Moscicki AB, Shiboski S, Hills NK et al (2004) Regression of low-grade squamous intra-epithelial lesions in young women. Lancet 364(9446):1678–1683

    Article  PubMed  Google Scholar 

  134. Mourits MJE, Pieters WJ, Hollema H et al (1992) Three-group metaphase as a morphologic criterion of progressive cervical intraepithelial neoplasia. Am J Obstet Gynecol 167(3):591–595

    PubMed  CAS  Google Scholar 

  135. Muñoz N, Castellsagué X, De González AB et al (2006) Chapter 1: HPV in the etiology of human cancer. Vaccine 24(Suppl 3):S1–S10. Epub 2006 Jun 23

    Google Scholar 

  136. Murphy N, Heffron CC, King B et al (2004) p16INK4A positivity in benign, premalignant and malignant cervical glandular lesions: a potential diagnostic problem. Virchows Arch 445(6):610–615

    Article  PubMed  CAS  Google Scholar 

  137. Nasiell K, Nasiell M, Vaclavinkova V (1983) Behavior of moderate cervical dysplasia during long-term follow-up. Obstet Gynecol 61:609–614

    PubMed  CAS  Google Scholar 

  138. Negri G, Egarter-Vigl E, Kasal A et al (2003) p16INK4a is a useful marker for the diagnosis of adenocarcinoma of the cervix uteri and its precursors: an immunohistochemical study with immunocytochemical correlations. Am J Surg Pathol 27(2):187–193

    Article  PubMed  Google Scholar 

  139. Ng A (1993) Glandular diseases of the uterus. In: Keebler CM, Somrak TM (eds) The manual of cytotechnology. American Society of Clinical Pathologists, Chicago

    Google Scholar 

  140. Nieminen P, Kallio M, Hakama M (1995) The effect of mass screening on incidence and mortality of squamous and adenocarcinoma of cervix uteri. Obstet Gynecol 85(6):1017–1021

    Article  PubMed  CAS  Google Scholar 

  141. Ostor AG, Duncan A, Quinn M et al (2000) Adenocarcinoma in situ of the uterine cervix: an experience with 100 cases. Gynecol Oncol 79(2):207–210

    Article  PubMed  CAS  Google Scholar 

  142. Ostor AG, Pagano R, Davoren RAM et al (1984) Adenocarcinoma in situ of the cervix. Int J Gynecol Pathol 3:179–190

    Article  PubMed  CAS  Google Scholar 

  143. Park JJ, Genest DR, Sun D et al (1999) Atypical immature metaplastic-like proliferations of the cervix: diagnostic reproducibility and viral (HPV) correlates. Hum Pathol 30(10):1161–1165

    Article  PubMed  CAS  Google Scholar 

  144. Park TJ, Richart RM, Sun X-W et al (1996) Association between HPV type and clonal status of cervical squamous intraepithelial lesions (SIL). J Natl Cancer Instit 88(66):355–358

    CAS  Google Scholar 

  145. Park JJ, Sun D, Quade BJ et al (2000) Stratified mucin-producing intraepithelial lesions of the cervix: adenosquamous or columnar cell neoplasia? Am J Surg Pathol 24(10):1414–1419

    Article  PubMed  CAS  Google Scholar 

  146. Parkin DM (1991) Screening for cervix cancer in developing countries. In: Miller AB, Chamberlain J, Day NE, Hakama M, Prorok PC (eds) Cancer screening. Cambridge University Press, Cambridge, pp 184–198

    Google Scholar 

  147. Patten SF (1978) Diagnostic cytopathology of the uterine cervix. Karger, Basal

    Google Scholar 

  148. Pemberton FA, Smith GV (1929) The early diagnosis and prevention of carcinoma of the cervix: a clinical pathologic study of borderline cases treated at the Free Hospital for women. Am J Obstet Gynecol 17:165

    Google Scholar 

  149. Pieters WJ, Koudstaal J, Ploem-Zaajer JJ et al (1992) The three group metaphase as morphologic indicator of high ploidy cells in cervical intraepithelial neoplasia. Anal Quant Cytol Histol 14:227–232

    PubMed  CAS  Google Scholar 

  150. Pirog EC, Isacson C, Szabolcs MJ et al (2002) Proliferative activity of benign and neoplastic endocervical epithelium and correlation with HPV DNA detection. Int J Gynecol Pathol 21(1):22–26

    Article  PubMed  Google Scholar 

  151. Piyathilake CJ, Macaluso M, Alvarez RD et al (2009) Lower risk of cervical intraepithelial neoplasia in women with high plasma folate and sufficient vitamin B12 in the post-folic acid fortification era. Cancer Prev Res 2(7):658–664

    Article  CAS  Google Scholar 

  152. Plaxe SC, Saltzstein SL (1999) Estimation of the duration of the preclinical phase of cervical adenocarcinoma suggests that there is ample opportunity for screening. Gynecol Oncol 75(1):55–61

    Article  PubMed  CAS  Google Scholar 

  153. Pretorius RG, Zhang X, Belinson JL et al (2006) Distribution of cervical intraepithelial neoplasia 2, 3 and cancer on the uterine cervix. J Low Genit Tract Dis 10(1):45–50

    Article  PubMed  Google Scholar 

  154. Queiroz C, Silva TC, Alves VA et al (2006) Comparative study of the expression of cellular cycle proteins in cervical intraepithelial lesions. Pathol Res Pract 202(10):731–737

    Article  PubMed  CAS  Google Scholar 

  155. Queiroz C, Silva TC, Alves VA et al (2006) P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions. Pathol Res Pract 202(2):77–83

    Article  PubMed  CAS  Google Scholar 

  156. Quint KD, de Koning MN, Geraets DT et al (2009) Comprehensive analysis of Human Papillomavirus and Chlamydia trachomatis in in-situ and invasive cervical adenocarcinoma. Gynecol Oncol 114(3):390–394

    Article  PubMed  CAS  Google Scholar 

  157. Ratnam S, Franco EL, Ferenczy A (2000) Human papillomavirus testing for primary screening of cervical cancer precursors. Cancer Epidemiol Biomarkers Prev 9(9):945–951

    PubMed  CAS  Google Scholar 

  158. Renshaw AA, Mody DR, Lozano RL et al (2004) Detection of adenocarcinoma in situ of the cervix in Papanicolaou tests: comparison of diagnostic accuracy with other high-grade lesions. Arch Pathol Lab Med 128(2):153–157

    PubMed  Google Scholar 

  159. Richart RM (1973) Cervical intraepithelial neoplasia: a review. Pathol Ann 8:301–328

    CAS  Google Scholar 

  160. Richart RM (1990) A modified terminology for cervical intraepithelial neoplasia. Obstet Gynecol 75(1):131–133

    PubMed  CAS  Google Scholar 

  161. Richart RM, Lerch V, Baron B (1967) A time-lapse cinematographic study in vitro of mitosis in normal human cervical epithelium, dysplasia and carcinoma in situ. J Natl Cancer Instit 39:571

    CAS  Google Scholar 

  162. Riethdorf L, Riethdorf S, Lee KR et al (2002) Human papillomaviruses, expression of p16, and early endocervical glandular neoplasia. Hum Pathol 33(9):899–904

    Article  PubMed  CAS  Google Scholar 

  163. Robertson AJ, Anderson JM, Beck JS et al (1989) Observer variability in histopathological reporting of cervical biopsy specimens. J Clin Pathol 42(3):231–238

    Article  PubMed  CAS  Google Scholar 

  164. Ronnett BM, Manos MM, Ransley JE et al (1999) Atypical glandular cells of undetermined significance (AGUS): cytopathologic features, histopathologic results, and human papillomavirus DNA detection. Hum Pathol 30(7):816–825

    Article  PubMed  CAS  Google Scholar 

  165. Salani R, Puri I, Bristow RE (2009) Adenocarcinoma in situ of the uterine cervix: a metaanalysis of 1278 patients evaluating the predictive value of conization margin status. Am J Obstet Gynecol 200(2):182e1–182e5

    Article  Google Scholar 

  166. Sawaya GF, McConnell KJ, Kulasingam SL et al (2003) Risk of cervical cancer associated with extending the interval between cervical-cancer screenings. N Engl J Med 349(16):1501–1509

    Article  PubMed  CAS  Google Scholar 

  167. Schiffman M, Castle PE, Jeronimo J et al (2007) Human papillomavirus and cervical cancer. Lancet 370(9590):890–907

    Article  PubMed  CAS  Google Scholar 

  168. Schmidt C, Pretorius RG, Bonin M et al (1992) Invasive cervical cancer following cryotherapy for cervical intraepithelial neoplasia or human papillomavirus infection. Obstet Gynecol 80(5):797–800

    PubMed  CAS  Google Scholar 

  169. Sherman ME, Schiffman M, Cox JT et al (2002) Effects of age and HPV load on colposcopic triage: data from the ASCUS LSIL Triage Study (ALTS). J Natl Cancer Instit 94:102–107

    Article  Google Scholar 

  170. Sherman ME, Tabbara SO, Scott DR et al (1999) “ASCUS, rule out HSIL”: cytologic features, histologic correlates, and human papillomavirus detection. Mod Pathol 12(4):335–342

    PubMed  CAS  Google Scholar 

  171. Shin CH, Schorge JO, Lee KR et al (2000) Conservative management of adenocarcinoma in situ of the cervix. Gynecol Oncol 79(1):6–10

    Article  PubMed  CAS  Google Scholar 

  172. Shingleton HM, Richart RM, Wiener J et al (1968) Human cervical intraepithelial neoplasia. Fine structure of dysplasia and carcinoma in situ. Cancer Res 28:695–706

    PubMed  CAS  Google Scholar 

  173. Sigurdsson K, Sigvaldason H (2007) Is it rational to start population-based cervical cancer screening at or soon after age 20? Analysis of time trends in preinvasive and invasive diseases. Eur J Cancer 43(4):769–774

    Article  PubMed  Google Scholar 

  174. Smith JS, Green J, Berrington de Gonzalez A et al (2003) Cervical cancer and use of hormonal contraceptives: a systematic review. Lancet 361(9364):1159–1167

    Article  PubMed  Google Scholar 

  175. Smith JS, Lindsay L, Hoots B et al (2007) Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update. Int J Cancer 121(3):621–632

    Article  PubMed  CAS  Google Scholar 

  176. Snijders PJ, Steenbergen RD, Heideman DA et al (2006) HPV-mediated cervical carcinogenesis: concepts and clinical implications. J Pathol 208(2):152–164

    Article  PubMed  CAS  Google Scholar 

  177. Solomon D, Davey D, Kurman R et al (2002) The 2001 Bethesda System: terminology for reporting results of cervical cytology. JAMA 287(16):2114–2119

    Article  PubMed  Google Scholar 

  178. Solomon D, Stoler M, Jeronimo J et al (2007) Diagnostic utility of endocervical curettage in women undergoing colposcopy for equivocal or low-grade cytologic abnormalities. Obstet Gynecol 110(2):288–295

    Article  PubMed  Google Scholar 

  179. Stanley M (2003) Chapter 17: Genital human papillomavirus infections – current and prospective therapies. J Natl Cancer Inst Monogr (31):117–124

    Google Scholar 

  180. Steben M, Duarte-Franco E (2007) Human papillomavirus infection: epidemiology and pathophysiology. Gynecol Oncol 107(2 Suppl 1):S2–S5

    Article  PubMed  CAS  Google Scholar 

  181. Stoler MH, Schiffman M (2001) Interobserver reproducibility of cervical cytologic and histologic interpretations: realistic estimates from the ASCUS-LSIL Triage Study. JAMA 285(11):1500–1505

    Article  PubMed  CAS  Google Scholar 

  182. Szarewski A, Cuzick J (1998) Smoking and cervical neoplasia; a review of the evidence. J Epidemiol Biostat 3:229

    Google Scholar 

  183. Szarewski A, Maddox P, Royston P et al (2001) The effect of stopping smoking on cervical Langerhans’ cells and lymphocytes. BJOG 108(3):295–303

    PubMed  CAS  Google Scholar 

  184. Tase T, Okagaki T, Clark BA et al (1989) Human papillomavirus DNA in adenocarcinoma in situ, microinvasive adenocarcinoma of the uterine cervix and coexisting cervical squamous intraepithelial neoplasia. Int J Gynecol Pathol 8(1):8–17

    Article  PubMed  CAS  Google Scholar 

  185. Tase T, Okagaki T, Clark BA et al (1989) Human papillomavirus DNA in glandular dysplasia and microglandular hyperplasia: presumed precursors of adenocarcinoma of the uterine cervix. Obstet Gynecol 73(6):1005–1008

    Article  PubMed  CAS  Google Scholar 

  186. Tavassoli FA, Devilee P (eds) (2003) Pathology and genetics of tumours of the breast and female genital organs. World Health Organization Classification of Tumors. IARC, Lyon

    Google Scholar 

  187. Trowell JE (1985) Intestinal metaplasia with argentaffin cells in the uterine cervix. Histopathology 9:561–569

    Article  Google Scholar 

  188. Tsoumpou I, Arbyn M, Kyrgiou M et al (2009) p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis. Cancer Treat Rev 35(3):210–220

    Article  PubMed  CAS  Google Scholar 

  189. Ueda Y, Enomoto T, Miyatake T et al (2003) Monoclonal expansion with integration of high-risk type human papillomaviruses is an initial step for cervical carcinogenesis: association of clonal status and human papillomavirus infection with clinical outcome in cervical intraepithelial neoplasia. Lab Invest 83(10):1517–1527

    Article  PubMed  Google Scholar 

  190. Ursin G, Pike MC, Preston-Martin S et al (1996) Sexual, reproductive, and other risk factors for adenocarcinoma of the cervix: results from a population-based case-control study (California, United States) [see comments]. Cancer Causes Control 7(3):391–401

    Article  PubMed  CAS  Google Scholar 

  191. Van Ranst MS, Tachezy R, Delius H et al (1993) Taxonomy of the human papillomaviruses. Papillomavirus Rep 4:61–65

    Google Scholar 

  192. Wang SS, Sherman ME, Hildesheim A et al (2004) Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in the United States for 1976–2000. Cancer 100(5):1035–1044

    Article  PubMed  Google Scholar 

  193. Wang SS, Trunk M, Schiffman M et al (2004) Validation of p16INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa Rica. Cancer Epidemiol Biomarkers Prev 13(8):1355–1360

    PubMed  CAS  Google Scholar 

  194. Wang SS, Wheeler CM, Hildesheim A et al (2001) Human leukocyte antigen class I and II alleles and risk of cervical neoplasia: results from a population-based study in Costa Rica. J Infect Dis 184(10):1310–1314

    Article  PubMed  CAS  Google Scholar 

  195. Ward BE, Burkett BA, Peterson C et al (1990) Cytological correlates of cervical papillomavirus infection. Int J Gynecol Pathol 9:297–305

    Article  PubMed  CAS  Google Scholar 

  196. Wells M, Ostor AG, Franceschi S et al (2003) Epithelial tumors of the uterine cervix. In: Tavassoli FA, Devilee P (eds) Tumors of the breast and female genital organs. IARC, Lyon, pp 221–232

    Google Scholar 

  197. Wheeler CM, Hunt WC, Schiffman M et al (2006) Human papillomavirus genotypes and the cumulative 2-year risk of cervical precancer. J Infect Dis 194(9):1291–1299

    Article  PubMed  Google Scholar 

  198. Williams J (1888) Cancer of the uterus: Harveian lectures for 1886. Lewis, London

    Google Scholar 

  199. Winer RL, Hughes JP, Feng Q et al (2006) Condom use and the risk of genital human papillomavirus infection in young women. N Engl J Med 354(25):2645–2654

    Article  PubMed  CAS  Google Scholar 

  200. Winer RL, Lee SK, Hughes JP et al (2003) Genital human papillomavirus infection: incidence and risk factors in a cohort of female university students. Am J Epidemiol 157(3):218–226

    Article  PubMed  Google Scholar 

  201. Workshop NCI (1991) The revised Bethesda System for reporting cervical/vaginal cytologic diagnoses. Report of the 1991 Bethesda Workshop. JAMA 267:1892

    Google Scholar 

  202. Wright TC Jr (2006) Chapter 3: Pathology of HPV infection at the cytologic and histologic levels: basis for a 2-tiered morphologic classification system. Int J Gynaecol Obstet 94(Suppl 1):S22–S31

    Article  Google Scholar 

  203. Wright TC Jr, Cox JT, Massad LS et al (2002) 2001 consensus guidelines for the management of women with cervical cytological abnormalities. JAMA 287(16):2120–2129

    Article  PubMed  Google Scholar 

  204. Wright TC, Kuhn L (2006) Immunosuppression and the cervix: human immunodeficiency virus (HIV). In: Jordan JA, Singer A (eds) The cervix. Blackwell, Malden, pp 450–517

    Google Scholar 

  205. Wright TC, Kurman RJ (1994) A critical review of the morphologic classification systems of preinvasive lesions of the cervix: the scientific basis of the paradigm. Papillomavirus Rep 5:175–181

    Google Scholar 

  206. Wright TC Jr, Massad LS, Dunton CJ et al (2007) 2006 consensus guidelines for the management of women with abnormal cervical cancer screening tests. Am J Obstet Gynecol 197(4):346–355

    Article  PubMed  Google Scholar 

  207. Wright TC Jr, Massad LS, Dunton CJ et al (2007) 2006 consensus guidelines for the management of women with abnormal cervical screening tests. J Low Genit Tract Dis 11(4):201–222

    Article  PubMed  Google Scholar 

  208. Wright TC Jr, Massad LS, Dunton CJ et al (2007) 2006 consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situ. Am J Obstet Gynecol 197(4):340–345

    Article  PubMed  Google Scholar 

  209. Wright TC, Schiffman M (2003) Adding a test for human papillomavirus DNA to cervical-cancer screening. New Eng J Med 348(6):489–490

    Article  PubMed  Google Scholar 

  210. Young RH, Scully RE (1989) Atypical forms of microglandular hyperplasia of the cervix simulating carcinoma. Am J Surg Pathol 13:50–56

    Article  PubMed  CAS  Google Scholar 

  211. Zhang Q, Kuhn L, Denny LA et al (2007) Impact of utilizing p16INK4A immunohistochemistry on estimated performance of three cervical cancer screening tests. Int J Cancer 120(2):351–356

    Article  PubMed  CAS  Google Scholar 

  212. zur Hausen H (1977) Human papillomaviruses and their possible role in squamous cell carcinomas. Curr Top Microbiol Immunol 78:1–30

    Article  PubMed  CAS  Google Scholar 

  213. zur Hausen H (2002) Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2(5):342–350

    Article  PubMed  CAS  Google Scholar 

  214. zur Hausen H (2009) The search for infectious causes of human cancers: where and why (Nobel lecture). Angewandte Chemie 48(32):5798–5808

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Columbia Presbyterian Medical Center, 630 W. 168th Street, Room 16404, New York, NY, 10032, USA

    Thomas C. Wright

  2. Department of Pathology, Division of Gynecologic Pathology, Johns Hopkins University School of Medicine, Weinberg Building 2242, 401 N. Broadway, Baltimore, MD, 21231, USA

    Brigitte M. Ronnett

  3. Departments of Gynecology, Obstetrics, Pathology and Oncology, Division of Gynecologic Pathology, Johns Hopkins University School of Medicine, Weinberg Building Room 2242 401 N. Broadway, Baltimore, MD, 21231, USA

    Robert J. Kurman

  4. Jewish General Hospital, McGill University, 3755 Côte St. Catherine Road, Montreal, QC, H3T 1E2, Canada

    Alex Ferenczy

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  1. Departments of Gynecology, Obstetrics, Pathology and Oncology, The Johns Hopkins University School of Medicine and Director of Gynecologic Pathology, The Johns Hopkins Hospital, 401 N. Broadway, Weinberg Building Room 2242, Baltimore, MD, 21231, USA

    Robert J. Kurman (Richard W. TeLinde Distinguished Professor of Gynecologic Pathology) (Richard W. TeLinde Distinguished Professor of Gynecologic Pathology)

  2. Department of Pathology and Laboratory Medicine, Weill Cornell Medical College and New York Presbyterian Hospital, 525 East 68th Street, Starr 1015, New York, NY, 10065, USA

    Lora Hedrick Ellenson

  3. Department of Pathology, Johns Hopkins University School of Medicine, 401 N. Broadway, Weinberg Building 2242, Baltimore, MD, 21231, USA

    Brigitte M. Ronnett

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Wright, T.C., Ronnett, B.M., Kurman, R.J., Ferenczy, A. (2011). Precancerous Lesions of the Cervix. In: Kurman, R.J., Ellenson, L.H., Ronnett, B.M. (eds) Blaustein’s Pathology of the Female Genital Tract. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0489-8_5

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