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Human Papillomaviruses and Their Possible Role in Squamous Cell Carcinomas

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Current Topics in Microbiology and Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 78))

Abstract

The view that common warts (verrucae vulgares), juvenile warts (verrucae planae), and genital warts (condylomata acuminata) are caused by the same virus and that differences in appearance are the result of variations in location and host reactivity has been shared by dermatologists for several decades (Frey, 1924; Waelsch and Habermann, 1924; Young, 1964; Rowson and Mahy, 1967; Nasemann, 1974; Lever and Schaumburg-Lever, 1975). This has probably reduced the interest in specific types of human papillomas.

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References

  • Aaronson, C.M., Lutzner, M.A.: Epidermodyslasia verruciformis and epidermoid carcinoma. J.Am. Med. Assoc. 201, 775–777 (1967)

    CAS  Google Scholar 

  • Abul Nasr, A.L.: Cancer of the penis in Egypt. Kasr-El Aini J. Surg. 2, 271–275 (1961)

    Google Scholar 

  • Almeida, J.D., Goffe, A.P.: Antibody to wart virus in human sera demonstrated by electron microscopy and precipitin tests. Lancet 1965/11, 1205–1207

    Google Scholar 

  • Almeida, J.D., Howatson, A.F., Williams, M.G.: Electron microscope study of human warts; sites of virus production and nature of the inclusion bodies. J. Invest. Dermatol. 38, 337–345 (1962)

    PubMed  CAS  Google Scholar 

  • Almeida, J.D., Oriel, J.D., Stannard, L.M.: Characterization of the virus found in human genital warts. Microbios 3, 225–232 (1969)

    Google Scholar 

  • Al-Salem, T., Peal, A.R., Norris, C.M.: Miltiple papillomatosis of the lower respiratory tract: a clinical and pathologic study of eleven cases. Cancer 22, 1173–1184 (1968)

    Google Scholar 

  • Altmann, F., Basek, M., Stout, A.P.: Papillomatosis of the larynx with intreaepithelial anaplastic changes. Arch. Otolaryngol. 62, 478–485 (1955)

    CAS  Google Scholar 

  • Arnold, W.: Ätiologische Aspekte zur Frage der Entstehung der Larynxpapillome. Laryngol. Rhinol. Otol. 55, 102–111 (1976)

    CAS  Google Scholar 

  • Bauer, K.H., Friedrich, H.C.: Peniscarcinom auf dem Boden vorbehandelter Condylomata acuminata. Z. Hautkr. 39, 150–163 (1965)

    CAS  Google Scholar 

  • Baylar, J.C.: The incidence of independent tumors among uterine cancer patients. Cancer 16, 842–853 (1963)

    Google Scholar 

  • Becker, F.T., Walder, H.J., Larson, D.M.: Giant condylomata acuminata. Arch. Dermatol. 100, 184–186 (1969)

    PubMed  CAS  Google Scholar 

  • Biebl, M.: Seltene Formen von Peniskrebs. Zbl. Haut- u. Geschl.-Kr. 22, 138–142 (1927)

    Google Scholar 

  • Birch, H.: Premalignant lesions of the vulva. Sth. med. J. (Bgham, Ala.) 59, 1487–1492 (1965)

    Google Scholar 

  • Bjork, H., Teir, H.: Benign and malignant papilloma of the larynx in adults. Acta Otolaryngol. (Stockh.) 47, 95–104 (1957)

    CAS  Google Scholar 

  • Black, P.H., Hartley, H.W., Rowe, W.P., Huebner, R.J.: Transformation of bovine tissue culture cells by bovine papilloma virus. Nature (Lond.) 199, 1016–1018 (1963)

    CAS  Google Scholar 

  • Blank, H., Haines, H.: Viral diseases of the skin, 1975: a 25-year perspective. J. Invest. Dermatol. 67, 169–176 (1976)

    PubMed  CAS  Google Scholar 

  • Boiron, M., Levy, J.P., Thomas, M., Friedmann, J.C., Bernard, J.: Some properties of bovine papilloma virus. Nature (Lond.) 201, 423–424 (1964)

    CAS  Google Scholar 

  • Boutselis, J.G.: Intraepithelial carcinoma of the vulva. Am. J. Obstet. Gynecol. 113, 733–738 (1972)

    PubMed  CAS  Google Scholar 

  • Boyle, W.F., McCoy, E.G., Fogarty, W.A.: Electron microscopic identification of virus-like particles in laryngeal papilloma. Ann. Otol. Rhinol. Laryngol. 80, 693–699 (1971)

    PubMed  Google Scholar 

  • Boyle, W.F., Riggs, J.L., Oshiro, L.S., Lenette, E.H.: Electron microscopic identification of papova virus in laryngeal papilloma. Laryngoscope 83, 1102–1108 (1973)

    PubMed  CAS  Google Scholar 

  • Brack, H.: Die maligne Entartung spitzer Condylome. Inaug. Diss. University of Munich (1960)

    Google Scholar 

  • Brückner, H.: Perforierende, carcinomähnliche spitze Condylome am Penis. Zbl. Haut- u. Geschl.-Kr. 62, 453–459 (1939)

    Google Scholar 

  • Bulkley, G., Wendel, R., Gray hack, J.: Buschke-Loewenstein tumour of penis. J. Urol. 97, 731–733 (1967)

    PubMed  CAS  Google Scholar 

  • Buschke, A., Löwenstein, L.: Spitze Kondylome des Penis und ihre Beziehung zum Peniscarcinom. Zbl. Haut- u. Geschl.-Kr. 34, 773–774 (1930)

    Google Scholar 

  • Buschke, A., Löwenstein, L.: Über carcinomähnliche Condylomata acuminata des Penis. Arch. Dermatol. Syph. (Berlin) 163, 30--6 (1931)

    Google Scholar 

  • Buschke, A., Löwenstein, L.: Beziehungen der spitzen Condylome zu den Carcinomen des Penis. Arch. Dermatol. 163, 30–46 (1932)

    Google Scholar 

  • Buschke, A., Löwenstein, L.: Über die Beziehung von spitzen Kondylomen zu Carcinomen des Penis. Dtsch. Med. Wochenschr. 58, 809–812 (1932)

    Google Scholar 

  • Carrié, C.: Condylomata acuminata mit Übergang in Carcinome. Zbl. Haut- u. Geschl.-Kr. 63, 650–653 (1940)

    Google Scholar 

  • Charlewood, G.P., Shippel, S.: Vulval condylomata acuminata as a premalignant lesion in the Bantu. S. Afr. Med. J. 27, 149–151 (1953)

    PubMed  CAS  Google Scholar 

  • Cheville, N.F.: Studies on connective tissue tumors in the hamster produced by bovine papilloma virus. Cancer Res. 26, 2334–2339 (1966)

    PubMed  CAS  Google Scholar 

  • Cheville, N.F., Olson, C.: Cytology of the canine oral papilloma. Am. J. Pathol. 45, 849–859

    Google Scholar 

  • Clarke, G.H.V.: The charming of warts. J. Invest. Dermatol. 45, 15–21 (1965)

    PubMed  CAS  Google Scholar 

  • Cook, P.J., Burkitt, D.P.: Cancer in Africa. Br. Med. Bull. 27, 14–20 (1971)

    PubMed  CAS  Google Scholar 

  • Cook, T.A.: Laryngeal papilloma: etiologic and therapeutic considerations. Ann. Otol. 82, 649–655 (1973)

    CAS  Google Scholar 

  • Crawford, L.V.: A study of human papilloma virus DNA. J. Mol. Biol. 13, 362–372 (1964)

    Google Scholar 

  • Crawford, L.V., Crawford, E.M.: A comparative study of polyoma and papilloma viruses. Virology 21, 258–263 (1963)

    PubMed  CAS  Google Scholar 

  • Cubie, H.A.: Failure to produce warts on human skin grafts on nude mice. Br. J. Dermatol. 94, 659–665 (1976)

    PubMed  CAS  Google Scholar 

  • Dahmen, O.: Carcinomähnliche spitze Condylome am Penis. Zbl. Haut- u. Geschl.-Kr. 37, 418–422 (1931)

    Google Scholar 

  • Davies, S. W.: Giant condylomata acuminata: Incidence among cases diagnosed as carcinoma of the penis. J. clin. Pathol. 18, 142–149 (1965)

    PubMed  CAS  Google Scholar 

  • Davis, C.L., Kemper, H.E.: Common warts (papillomata) in goats. J. Am. Vet. Med. Assoc. 41, 175–179 (1936)

    Google Scholar 

  • Dawson, D.F., Duckworth, J.K., Bernhardt, H., Young, J.M.: Giant condyloma and verrucous carcinoma of the genital area. Arch. Pathol. 79, 225–231(1965)

    Google Scholar 

  • De Armas, R.: A case of giant condyloma acuminatum (in Spanish). Arch. Cuban Cancer 16, 314–318 (1957)

    Google Scholar 

  • Delap, R., Frieman-Kien, A., Rush, M.G.: The absence of human papilloma viral DNA sequences in condylomata acuminata. Virology 74, 268–272 (1976)

    PubMed  CAS  Google Scholar 

  • Delbanco, E., Unna, P.G.: Über die condylomatoide Praekanzerose der Genitalgegend. Dermatol. Wochenschr. 128, 1403–1407 (1928)

    Google Scholar 

  • Delescluse, C., Prunier as, M., Regnier, M., Moreno, G., Aroute, J.: Epidermodysplasia verruciformis. I. Electron microscope autoradiography and tissue culture studies. Arch. Dermatol. Forsch. 242, 202–215 (1972)

    PubMed  CAS  Google Scholar 

  • Djordjevitch, B.: Condylomes géantes de la verge. Strasbourg Méd. 88, 70–74 (1928)

    Google Scholar 

  • Dodge, O.G., Linsell, C.A., Davies, J.N.P.: Circumcision and the incidence of carcinoma of the penis and the cervix. East Afr. Med. J. 40, 440–444 (1963)

    PubMed  CAS  Google Scholar 

  • Doll, R., Payne, P., Waterhouse, J. (eds.): Cancer Incidence in Five Continents. New York: Springer-Verlag (1966)

    Google Scholar 

  • Domaniewski, J., Güstowski, A.: Planoepithelial, spinocellular cancer of the vulva, originating from condylomata acuminata. Ginekol. Pol. 39, 239–242 (1968)

    PubMed  CAS  Google Scholar 

  • Dreyfuss, W., Neville, W.F.: Buschke-Loewenstein tumors (giant condylomata acuminata). Am. J. Surg. 90, 146–150 (1955)

    PubMed  CAS  Google Scholar 

  • Duff, T.B.: Laryngeal papillomatosis. J. Laryngol. Otol. 85, 947–956 (1971)

    PubMed  CAS  Google Scholar 

  • Duncan, J.R., Corbeil, L.B., Davies, D.H., Schultz, R.D., Whitlock, R.H.: Persistent papillomatosis associated with immunodeficiency. Cornell Vet. 65, 205–211 (1975)

    PubMed  CAS  Google Scholar 

  • Eberhartinger, C.: Maligne degenerierte Condylomata acuminata. Dermatol. Wochenschr. 138, 975–977 (1958)

    Google Scholar 

  • Eckel, W.: Kehlkopfpapillome und deren carcinomatöse Entartung, entstanden jeweils während der Schwangerschaft. HNO 6, 197–200 (1957)

    PubMed  CAS  Google Scholar 

  • Edsmyr, F.: Carcinoma of the vulva. An analysis of 560 patients with histologically verified sqamous cell carcinoma. Acta. Radiol. [Suppl.] (Stockh.) 217, 1–135 (1962)

    Google Scholar 

  • Eisinger, M., Kucarova, O., Sarkar, N.H., Good, R.A.: Propagation of human wart virus in tissue culture. Nature (Lond.) 256, 432–434 (1975)

    CAS  Google Scholar 

  • Ekstrom, T.E., Edsmyr, F.: Cancer of the penis. A clinical study of 229 cases. Acta. Chir. Scand. 115, 25–37 (1958)

    PubMed  CAS  Google Scholar 

  • Embrey, M.P.: Vuval carcinoma complicating condylomata acuminata. J. Obstet. Gynaecol. Br. Cwlth. 68, 503–504 (1961)

    CAS  Google Scholar 

  • Evans, J.A.: Bracken fern toxin. In: Oncology 70, Proc. Xth Int. Cancer Congr. Houston, Chicago Year Book Med. Publ. 5, part A, 178–195 (1971)

    Google Scholar 

  • Evans, R.L., Dische, F.E.: A large condyloma of the vagina. J. Obstet. Gynaecol. Br. Cwlth. 76, 757–760 (1969)

    CAS  Google Scholar 

  • Faragö, L., Nagy, A.: Über einen seltenen Fall von maligner Entartung eines kindlichen Larynxpapilloms. Monatsschr. Ohrenheilkd. 3, 131–135 (1966)

    Google Scholar 

  • Favre, M., Breitburd, F., Croissant, O., Orth, G.: Structural polypeptides of rabbit, bovine, and human papillomaviruses. J. Virol. 15, 1239–1247 (1975a)

    PubMed  CAS  Google Scholar 

  • Favre, M., Orth, G., Croissant, O., Yaniv, M.: Human papilloma virus DNA: physical map. Proc. Natl. Acad. Sci. USA 72, 4810–4814 (1975b)

    PubMed  CAS  Google Scholar 

  • Fey, G., Hirt, B.: Fingerprints of polyoma virus proteins and mouse histones. Cold Spring Harbor Symp. Quant. Biol. 39, 235–241 (1974)

    Google Scholar 

  • Fisher, I., Haas, C.F.: Giant condyloma (verruca) simulating carcinoma of the penis. Minn. Med. 38, 423–427 (1955)

    PubMed  CAS  Google Scholar 

  • Flint, S.J., Gallimore, P.H., Sharp, P.A.: Comparison of viral RNA sequences in adenovirus 2-transformed and lytically infected cells. J. Mol. Biol. 96, 47–68 (1975)

    PubMed  CAS  Google Scholar 

  • Flint, S.J., Sambrook, J., Williams, J.F., Sharp, P.A.: Viral nucleic acid sequences in transformed cells. IV. A study of the sequences of adenovirus 5 DNA and RNA in four lines of adenovirus 5-transformed rodent cells using specific fragments of the viral genome. Virology 72, 456–470 (1976)

    PubMed  CAS  Google Scholar 

  • Frei, W.: Über „carcinomähnliche“ spitze Condylome am Penis. Arch. Dermatol. 160, 109–113 (1929)

    Google Scholar 

  • Frey, E.: Zur Frage der ätiologischen Beziehungen der Warzen und spitzen Kondylome. Schweiz. Med. Wochenschr. 5, 215–219 (1924)

    Google Scholar 

  • Friedberg, M.J., Serlin, O.: Condyloma acuminatum: its association with malignancy. Dis. Colon Rectum 6, 352–355 (1963)

    PubMed  CAS  Google Scholar 

  • Friedberg, S.A., Stagman, R., Hass, G.M.: Papillary lesions of the larynx in adults: a pathologic study. Ann. Otol. Rhinol. Laryngol. 80, 683–692 (1971)

    PubMed  CAS  Google Scholar 

  • Friedmann, J.M., Fialkow, P.J.: Viral “tumorigenesis” in man: cell markers in condylomata acuminata. Int. J. Cancer 17, 57–61 (1976)

    Google Scholar 

  • Galloway, T.C., Soper, G.R., Elsen, J.: Carcinoma of the larynx after irradiation for papilloma. Arch. Otolaryngol. 72, 289–294 (1960)

    PubMed  CAS  Google Scholar 

  • Gardner, H.L., Kaufmann, R.H.: Benign Diseases of the Vulva and Vagina. San Louis: C.V. Mosby 1969

    Google Scholar 

  • Genner, J.: Verrucae vulgares. I.I. Demonstration of a complement fixation reaction. Acta. Derm. Venereol. (Stockh.) 51, 365–370 (1971)

    CAS  Google Scholar 

  • Gersh, J.: Giant condyloma acuminata (carcinoma-like or Buschke-Löwenstein tumors) of penis. J. Urol. (Baltimore) 69, 164–172 (1953)

    CAS  Google Scholar 

  • Gibbs, A.G., Khan, A.: Papilloma of the trachea. J. Laryngol. Otol. 85, 1205–1207 (1971)

    Google Scholar 

  • Gibbs, E.P.J., Smale, C.J., Lawman, M.P.J.: Warts in sheep. J. Comp. Pathol. 85, 327–334 (1975)

    PubMed  CAS  Google Scholar 

  • Gilbert, C.F.: Giant condyloma acuminatum (Buschke-Loewenstein tumor). Arch. Dermatol. 93, 714–717 (1966)

    PubMed  CAS  Google Scholar 

  • Gissmann, L.: Vergleichende Charakterisierung der Desoxyribonukleinsäuren menschlicher Papillomviren (HPV). Inaug. Diss. Universität Erlangen-Nuremberg (1977)

    Google Scholar 

  • Gissmann, L., zur Hausen, H.: Human papilloma viruses: physical mapping and genetic heterogeneity. Proc. Natl. Acad. Sci. U.S.A. 73, 1310–1313 (1976)

    PubMed  CAS  Google Scholar 

  • Gissmann, L., zur Hausen, H.: Inverted repetitive sequences in human papilloma virus 1 (HPV 1) DNA. Virology, in press (1977)

    Google Scholar 

  • Gissmann, L., Pfister, H., zur Hausen, H.: Human papilloma viruses (HPV): Characterization of 4 different isolates. Virology 76, 569–580 (1977)

    PubMed  CAS  Google Scholar 

  • Goffe, A.P., Almeida, J.D., Brown, F.: Further information on the antibody response to wart virus. Lancet 1966/11, 607–608

    Google Scholar 

  • Gordon, D.E., Olson, C.: Meningeomas and fibroblastic neoplasia in calves induced with the bovine papilloma virus. Cancer Res. 28, 2423–2431 (1968)

    PubMed  CAS  Google Scholar 

  • Graber, E.A., Barber, A.R.K., O’Rourke, J.J.: Simple surgical treatment for condyloma acuminatum of the vulva. Obstet. Gynecol. 29, 247–250 (1967)

    PubMed  CAS  Google Scholar 

  • Graffi, A., Bender, E., Schramm, T., Kuhn, W., Schneiders, F.: Induction of transmissible lymphomas in Syrian hamsters by application of DNA from viral hamster papovavirus- induced tumors and by cell-free filtrates from human tumors. Proc. Natl. Acad. Sci. U.S.A. 64, 1172–1176 (1969)

    PubMed  CAS  Google Scholar 

  • Graham, F.L., Van Der Eb, A.J., Heijneker, H.L.: Size and location of the transforming region in human adenovirus type 5 DNA. Nature (Lond.) 252, 687–691 (1974)

    Google Scholar 

  • Green, M.: Oncogenic viruses. Ann. Rev. Biochem. 39, 701–756 (1970)

    PubMed  CAS  Google Scholar 

  • Green, T.H., Ulfelder, H., Meigs, J.V.: Epidermoid carcinoma of the vulva: an analysis of 238 cases. Am. J. Obstet. Gynecol. 75, 834–847 (1958)

    PubMed  Google Scholar 

  • Grussendorf E.I., Gahlen, W.: Morbus Bowen bei Condylomata acuminata. Hautarzt 25, 443–47 (1974)

    PubMed  CAS  Google Scholar 

  • Grussendorf, E.I., Gahlen, W.: Metaplasia of a verruca vulgaris into spinocellular carcinoma. Dermatologica 150, 295–299 (1975)

    PubMed  CAS  Google Scholar 

  • Hanash, K.A., Furlow, W.L., Utz, D.C., Harrison, E.G.: Carcinoma of the penis: a clinico- pathologic study. J. Urol. 104, 291–297 (1970)

    PubMed  CAS  Google Scholar 

  • Hertig, A.T., Gore, H.: Tumors of the vulva, vagina and uterus. In: Atlas of Tumor Pathology, Section IX-Fasciele 33, Part II, Washington, D.C.: Armed Forces Inst. Pathol. (1960)

    Google Scholar 

  • Hotchkiss, R.S., Rouse, A.J.: Papillomatosis of the bladder and ureters, preceded by condy- omata acuminata of the vulva: a case report. J. Urol. 100, 723–725 (1968)

    PubMed  CAS  Google Scholar 

  • Ikuta, F., Inomata, N., Kumanishi, T.: Virions and cell alterations in epidermodysplasia verruciformis with malignancy: electron microscopic studies. Gann 10, 3–27 (1971)

    Google Scholar 

  • Ishikawa, K.: Klinische und experimentelle Untersuchungen über die Entstehungsursachen der Papillome. Fukuoka Acta Med. 29, 87–88 (1936)

    Google Scholar 

  • Israel, W.: Zur Kenntnis der atypischen Condylomata acuminata des Penis. Zbl. Haut- u. Geschl.-Kr. 29, 386–392 (1929)

    Google Scholar 

  • Jablonska, S., Milewski, B.: Zur Kenntnis der Epidermodysplasia verruciformis Lewan- dowsky-Lutz. Dermatologica 115, 1–22 (1957)

    PubMed  CAS  Google Scholar 

  • Jablonska, S., Formas, I.; Weitere positive Ergebnisse mit Auto- und Heteroinokulation bei Epidermodysplasia verruciformis Lewandowsky-Lutz. Dermatologica 118, 86–93 (1959)

    Google Scholar 

  • Jablonska, S., Fabjanska, L., Formas, I.: On the viral etiology of epidermodysplasia verruciformis. Dermatologica 132, 369–385 (1966)

    PubMed  CAS  Google Scholar 

  • Jablonska, S., Biczysko, W., Jakubowicz, W., Dabrowski, H.: The ultrasturcture of transitional states to Bowen’s disease and invasive Bowen’s carcinoma in epidermodysplasia verruciformis. Dermatologica 140, 186–194 (1970)

    PubMed  CAS  Google Scholar 

  • Jablonska, S., Dabrowski, J., Jakubowicz, K.: Epidermodysplasia verruciformis as a model in studies on the role of papovaviruses in oncogenesis. Cancer Res. 32, 583–589 (1972)

    PubMed  CAS  Google Scholar 

  • Jagella, H.P., Stegner, H.E.: Zur Dignität der Condylomata acuminata. Klinische, histopa- thologische und cytophotometrische Befunde. Arch. Gynaekol. 216, 119–132 (1974)

    CAS  Google Scholar 

  • James, P.D., Taylor, C.W., Templeton, A.C.: Tumours of the female genitalia. In: Tumours in a Tropical Country. Templeton, A.C. (ed.), Heidelberg: Springer-Verlag 1973, pp. 101–131

    Google Scholar 

  • Judge, J.R.: Giant condyloma acuminatum involving vulva and rectum. Arch. Pathol. 88, 46–48 (1969)

    PubMed  CAS  Google Scholar 

  • Justus, J., Baerthold, W., Preibisch-EJfenberger, R.: Juvenile Larynxpapillomatose mit Ausbreitung über das Tracheobronchialsystem und maligne Entartung ohne Strahlentherapie. HNO 18, 349–354 (1970)

    PubMed  CAS  Google Scholar 

  • Kaiser, R.: Maligne Entartung eines kindlichen Larynxpapilloms. Monatsschr. Ohrenheilkd. 98, 233–238 (1964)

    CAS  Google Scholar 

  • Kerl, H., Pickel, H.: Maligne Umwandlung von Condylomata acuminata der Vulva. Zbl. Haut- u. Geschl.-Kr. 46, 155–162 (1971)

    Google Scholar 

  • Kleimann, H., Lancaster, F.; Condyloma acuminata of the bladder. J. Urol. 88, 52–55 (1962)

    Google Scholar 

  • Kleinsasser, O., Oliveirae Cruz, G.: “Juvenile” und “adulte” Kehlkopfpapillome. HNO 21, 97–106 (1973)

    PubMed  CAS  Google Scholar 

  • Knierer, W.: Spitze Condylome am Penis mit destruierendem Wachstum. Dermatol. Wo- chenschr. 112, 54–57 (1941)

    Google Scholar 

  • Knoblich, R., Failing, J.F.: Giant condyloma acuminatum (Buschke-Loewenstein Tumor) of the rectum. Am. J. Clin. Path. 48, 389–395 (1967)

    PubMed  CAS  Google Scholar 

  • Koller, L.D., Olson, C.: Attempted transmission of warts from man, cattle, and horses and of deer fibroma, to selected hosts. J. Invest. Dermatol. 58, 366–368 (1972)

    PubMed  CAS  Google Scholar 

  • Konjetzny, G.E.: Über einen ungewöhnlichen Penistumor. Münch. Med. Wochenschr. 61, 904–905 (1914)

    Google Scholar 

  • Kovi, J., Tillman, L., Lee, S.M.: Malignant transformation of condyloma acuminatum. Am. J. Clin. Pathol. 61, 702–710 (1974)

    PubMed  CAS  Google Scholar 

  • Kramann, H.: Zur Frage der Carcinomentstehung auf dem Boden des Condyloma acuminatum. Zentralbl. Gynaekol. 65, 1932–1935 (1941)

    Google Scholar 

  • Krause, P.: Condylomata acuminata auf Stachelzellkrebs. Zbl. Haut- u. Geschl.-Kr. 75, 95–97 (1950)

    Google Scholar 

  • Lai, M.M., Yadav, M.S., Dhall, J.C.: Giant condylomata acuminata. Indian J. Dermatol. 20, 51–55 (1975)

    Google Scholar 

  • Lancaster, W.D., Meinke, W.: Restriction endonuclease cleavage patterns of human papilloma viral DNA. ASM Abstr. (Suppl.) 29, 209 (1976)

    Google Scholar 

  • Lancaster, W.D., Meinke, W.: Persistence of viral DNA in human cell cultures infected with human papilloma virus. Nature (Lond.) 256, 434–436 (1975)

    CAS  Google Scholar 

  • Lancaster, W.D., Olson, C., Meinke, W.: Quantitation of bovine papilloma viral DNA in viral-induced tumors. J. Virol. 17, 824–831 (1976)

    PubMed  CAS  Google Scholar 

  • Lancaster, W.D., Olson, C., Meinke, W.: Bovine papilloma virus: Presence of viral-specific DNA in naturally occurring equine tumors. Proc. Natl. Acad. Sci. U.S.A. (1977) (in press)

    Google Scholar 

  • Langer, E.: Maligne spitze Kondylome. Zbl. Haut- u. Geschl.-Kr. 40, 448–50 (1932)

    Google Scholar 

  • Laurent, R., Agache, P., Coume-Marquet, A.: Ultrastructure of clear cells in human viral warts. J. Cutan. Pathol. 2, 140–148 (1975)

    Google Scholar 

  • Le Jeune, F.E.: The story of Warren Bell. Ann. Otol. Rhinol. Laryngol. 50, 905–908 (1941)

    Google Scholar 

  • Lepow, H., Leffler, N.: Giant condylomata acuminata (Buschke-Loewenstein tumor); report of two cases. J. Urol. 83, 853–858 (1960)

    PubMed  CAS  Google Scholar 

  • Lever, W.F., Schaumburg-Lever, G.: In: Histopathology of the skin, 5th Edition, J.B. Lippincott, Co., Philadelphia, Toronto, pp. 337–360 (1975)

    Google Scholar 

  • Levi, I.: Sopra un caso di condylomi acuminati a carattere infiltrativo. Dermosifilografo 9, 210–219 (1934)

    Google Scholar 

  • Lewandowsky, F., Lutz, W.: Ein Fall einer bisher nicht beschriebenen Hauterkrankung (Epidermodysplasia verruciformis). Arch. Dermatol. Syph. (Berlin) 141, 193–203 (1922)

    Google Scholar 

  • Lewis, H.Y., Wolf, P.L., Pierce, J.M.: Condyloma acuminatum of the bladder. J. Urol. 88, 248–251 (1962)

    PubMed  CAS  Google Scholar 

  • Limburg, H.: Epitheliale gutartige Geschwülste. In: Gynäkologie und Geburtshilfe, Vol. III, Spezielle Gynäkologie, Käser, O., Friedberg, V., Ober, KG., Thomsen, K, Zander, J. (eds.). Stuttgart: Georg Thieme-Verlag 1972

    Google Scholar 

  • Lister, U.M., Akinla, O.: Carcinoma of the vulva in childhood. J. Obstet. Gynaecol. Br. Cwlth. 79, 470–473 (1972)

    CAS  Google Scholar 

  • Litvak, A.S., Melnick, I., Liebermann, P.R.: Giant condylomata acuminata associated with carcinoma. J. Med. Soc. N.Y. 63, 165–167 (1966)

    CAS  Google Scholar 

  • Loewenstein, L. W.: Carcinoma-like condylomata acuminata of the penis. Med. Clin. North. Am. 23, 789–795 (1939)

    Google Scholar 

  • Lundquist, P.G., Frithiof, L., Wersäll, J.: Ultrastructural features of human juvenile laryngeal papillomas. Acta Otolaryngol. 80, 137–149 (1975)

    PubMed  CAS  Google Scholar 

  • Lutz, W.: A propos de l’epidermodysplasie verruciforme. Dermatologica 92, 30–43 (1946)

    PubMed  CAS  Google Scholar 

  • Lynch, J.B., El Hassan, A.M., Omer, A.: Cancer in the Sudan. Sudan Med. J. 2, 29–34 (1963)

    Google Scholar 

  • McCart, H.: Tracheal and bronchial papillomatous implants showing malignant changes. Ann. Otol. Rhinol. Laryngol. 63, 498–499 (1954)

    PubMed  CAS  Google Scholar 

  • MacDonald, C.: Venereal wart converted into carcinoma by cauterization. Illinois Med. J. 40, 233–235 (1921)

    Google Scholar 

  • Machacek, G.F., Weakley, D.R.: Giant condylomata acuminata of Buschke-Loewenstein. Arch. Dermatol. (Chicago) 63, 383–385 (1970)

    Google Scholar 

  • McKenna, H., Fraser, M., Silverstone, H.: Squamous papilloma of the cervix uteri. A two year prospective cytological study. Med. J. Aust. 2, 304–306 (1975)

    Google Scholar 

  • MacMahon, B., Austin, J.H.: Association of carcinomas of the breast and corpusuteri. Cancer 23, 275–280 (1969)

    PubMed  CAS  Google Scholar 

  • Maier, I.; Maligne Entartung bestrahlter juveniler Larynxpapillome. Z. Laryngol. Rhinol. 47, 862–869 (1968)

    CAS  Google Scholar 

  • Majanz, A.J.: Über karzinomähnliche Erkrankungen des Penis. Z. Urol. 22, 620–625 (1928)

    Google Scholar 

  • Majoros, M., Parkhill, E.M., Devine, K.D.: Papillomas of the larynx in children. A clinico- pathologic study. Am. J. Surg. 108, 470–479 (1964)

    PubMed  CAS  Google Scholar 

  • Malik, M.O.H., Hidayfalla, A., Daoud, E.H., El Hassan, A.M.: Superficial cancer in the Sudan. A study of 1225 primary malignant superficial tumors. Br. J. Cancer 30, 355–364 (1974)

    PubMed  CAS  Google Scholar 

  • Marino, Jr., A.W.: Proctologic lesions observed in male homosexuals. Dis. Colon Rectum 7, 121–125 (1964)

    PubMed  Google Scholar 

  • Marsden, A.T.H.: The geographical pathology of cancer in Malaya. Br. J. Cancer 12, 162–169 (1958)

    Google Scholar 

  • Martinez, I.: Relationship of squamous cell carcinoma of the cervix uteri to squamous cell carcinoma of the penis. Cancer 24, 777–780 (1969)

    PubMed  CAS  Google Scholar 

  • Matthews, R.S., Shirodaria, P. V.: Study of regressing warts by immunofluorescence. Lancet 1973/I 689–691

    Google Scholar 

  • Meisels, A., Fortin, R.: Condylomatous lesions of the cervix and vagina. 1. Cytological patterns. Act. Cytologica 20, 505–509 (1976)

    CAS  Google Scholar 

  • Meisels, A., Fortin, R., Roy, M.: Condylomatous lesions of the cervix. II. Cytologic, colposcopic and histopathologic study. (1977) (Submitted for publication)

    Google Scholar 

  • Menakanit, W., Muir, C.S., Jain, D.K.: Cancer in Chiang Mai, North Thailand. A relative frequency study. Br. J. Cancer 25, 225–236 (1971)

    PubMed  CAS  Google Scholar 

  • Mickal, A., Andonie, J.A., Dougherty, C.M.: Squamous cell carcinoma of the vulva. Obstet. Gynecol. 28, 670–674 (1966)

    PubMed  CAS  Google Scholar 

  • Montes, L.F., Vaughan, J.T.: Warts. J. Cutan. Pathol. 2, 161–165 (1975)

    Google Scholar 

  • Moriamé, G.: Transformation maligne de végétations vénériennes de la verge. Arch. Belg. Dermatol. 6, 175–177 (1950)

    Google Scholar 

  • Morison, W.L.: In vitro assay of immunity to human wart antigen. Br. J. Dermatol. 93, 545–551 (1975a)

    PubMed  CAS  Google Scholar 

  • Morison, W.L.: Cell-mediated immune responses in patients with warts. Br. J. Dermatol. 93, 553–556 (1975b)

    PubMed  CAS  Google Scholar 

  • Morison, W.L.: Viral warts, herpes, simplex and herpes zoster in patients with secondary immune deficiencies and neoplasms. Br. J. Dermatol. 92, 625–630 (1975c)

    PubMed  CAS  Google Scholar 

  • Mühlpfordt, H.: Spitze Kondylome und Carcinom im selben Tumor. Klinik, Histopathologic und Therapie der kondylomatoiden Präcancerose der Genitalgegend (Delbanco-Unna). Dermatol. Wochenschr. 93, 1145–1162 (1930)

    Google Scholar 

  • Murray, R.F., Hobbs, J., Payne, B.: Possible clonal origin of common warts (verruca vulgaris). Nature (Lond.) 232, 51–52 (1971)

    CAS  Google Scholar 

  • Nasemann, T.H.: Viruskrankheiten der Haut, der Schleimhäute und des Genitales. Stuttgart: Georg Thieme-Verlag 1974

    Google Scholar 

  • Nath, K.S., Grewall, K.S.: Cancer in India. Indian J. Med. Res. 24, 633–639 (1936)

    Google Scholar 

  • Newell, G.R., Rawlings, W., Krementz, E.T.: Multiple primary neoplasms in blacks compared to whites. III. Initial cancers of the female breast and uterus. J. Natl. Cancer Inst. 53, 369–373 (1974)

    PubMed  CAS  Google Scholar 

  • Newell, G.R., Krementz, E.T., Roberts, J.D.: Excess occurrence of cancer of the oral cavity, lung, and bladder following cancer of the cervix. Cancer 36, 2155–2158 (1975)

    PubMed  CAS  Google Scholar 

  • Nexmand, P.H.: Carcinoma of penis, testis, epididimys and perineum. Malignant degenerations of condylomes. Acta Derm. Venerol. 36, 186–198 (1956)

    Google Scholar 

  • Ngai, S.K.: The aetiological and pathological aspects of squamous cell carcinoma of the penis among the Chinese; an analytical study of 107 cases. Am. J. Cancer 19, 259–269 (1933)

    Google Scholar 

  • Nielsen, H. V.: Condylomata acuminata of the bladder. Scand. J. Urol. Nephrol. 9, 169–170 (1975)

    PubMed  CAS  Google Scholar 

  • Novak, E.: Gynecological and Obstetrical Pathology. Philadelphia-London: W.B. Saunders 1947

    Google Scholar 

  • Oehlschlaegel, G., Rakosi, J.: Verrucosis generalisata bei Hypoproteinamie und Hypogam- maglobulinamie. Z. Hautkr. 50, 922–924 (1975)

    PubMed  CAS  Google Scholar 

  • Ogilvie, O.E.: Multiple papillomas of trachea with malignant degeneration. Arch. Otolaryngol. 58, 10–18 (1953)

    CAS  Google Scholar 

  • Ogilvie, M.M.: Serological studies with human papova (wart) virus. J. Hyg. (Camb.) 68, 479–483 (1970)

    CAS  Google Scholar 

  • Olnwasanni, J.A., Olufemi, A., Williams, A., Alii, A.F.: Superficial cancer in Nigeria. Br. J. Cancer 23, 714–728 (1969)

    Google Scholar 

  • Olson, C., Cook, R.H.: Cutaneous sarcoma-like lesions of the horse caused by the agent of bovine papilloma. Proc. Soc. Exp. Biol. Med. 77, 281–284 (1951)

    PubMed  Google Scholar 

  • Olson, C., Pamucku, A.M., Brobst, D.F.: Papilloma-like virus from bovine urinary bladder tumors. Cancer Res. 25, 840–846 (1965)

    PubMed  CAS  Google Scholar 

  • Olson, C., Robl, M.G., Larson, L.L.: Cutaneous and penile bovine fibropapillomatosis and its control. J. Am. Vet. Med. Assoc. 153, 1189–1194 (1968)

    PubMed  CAS  Google Scholar 

  • Oppenheim, H.: Wahrscheinlich spinocellulares Epitheliom der gesamten Penishaut mit spitzen Condylomen an der Peniswurzel. Dermatol. Wochenschr. 107, 849–856 (1938)

    Google Scholar 

  • Oranje, A.P., Brouwer, J., Vuzevski, V.D.: Condyloma-like penis carcinoma. Dermatologica 152, 47–54 (1976)

    PubMed  CAS  Google Scholar 

  • Oriel, J.D.: Natural History of genital warts. Br. J. Vener. Dis. 47, 1–8 (1971a)

    PubMed  CAS  Google Scholar 

  • Oriel, J.D.: Anal warts and anal coitus. Br. J. Vener. Dis. 47, 373–376 (1971b)

    PubMed  CAS  Google Scholar 

  • Oriel, J.D., Whimster, I.W.: Carcinoma in situ associated with virus-containing anal warts. Br. J. Dermatol. 84, 71–73 (1971b)

    PubMed  CAS  Google Scholar 

  • Pass, F., Maizel, J.V.: Wart-associated antigens. II. Human immunity to viral structural proteins. J. Invest. Dermatol. 60, 307–311 (1973)

    CAS  Google Scholar 

  • Pass, F., Marcus, D.M.: Wart-associated antigens. I. Isolation of tissue antigens using antibody immunoadsorbents. J. Invest. Dermatol. 60, 301–306 (1973)

    CAS  Google Scholar 

  • Patankar, V.J., Dimre, M.S., Potnis, A.G., Mudbhatkal, N.S.: Buschke-Loewenstein tumor of penis. Indian J. Dermatol. 32, 225–228 (1966)

    Google Scholar 

  • Paul, M.: Cancer of the penis in Ceylon. Ann. R. Coll. Surg. Engl. 20, 50–54 (1957)

    PubMed  CAS  Google Scholar 

  • Peirone, F.: Rilievi notologici su di un caso di condilomatosi acuminata gigante. Minerva Med. 58, 292–294 (1967)

    PubMed  CAS  Google Scholar 

  • Pfister, H., Gissmann, L., zur Hausen, H.: Partial characterization of the proteins of human papilloma viruses (HPV) 1–3. Virology, in print (1977)

    Google Scholar 

  • Pons, S., Torres, A., Ortiz, A.: Sindrome de Loewenstein-Buschke. Arch. Argent. Dermatol. 17, 269–278 (1967)

    PubMed  CAS  Google Scholar 

  • Powell, L.C., Pollard, M., Jinkins, J.L.: Treatment of condyloma acuminata by autogenous vaccine. South. Med. J. Birmingham 63, 202–205 (1970)

    Google Scholar 

  • Powley, J.M.: Buschke-Loewenstein tumour of the penis. Br. J. Surg. 51, 76–77 (1964)

    PubMed  CAS  Google Scholar 

  • Putney, F.J.: Borderline malignant lesions of the larynx. Arch. Otolaryngol. 61, 381–385 (1955)

    CAS  Google Scholar 

  • Pyrhdnen, S., Penttinen, K.: Wart virus antibodies and the prognosis of wart disease. Lancet 1972/II, 1330–1332

    Google Scholar 

  • Qizilbash, A.H.: Papillary squamous tumours of the uterine cervix. Am. J. Clin. Pathol. 61, 508–512 (1974)

    PubMed  CAS  Google Scholar 

  • Reid, T.M.S., Fraser, N.G., Kernohan, I.R.: Generalized warts and immune deficiency. Br. J. Dermatol. 95, 559–564 (1976)

    PubMed  CAS  Google Scholar 

  • Riggio, T.: Contributo alia conoscenza delle frome di Buschke e Loewenstein del condiloma acuminato. Arch. Ital. Derm. Sif. 26, 472–82 (1954)

    CAS  Google Scholar 

  • Rotkin, I.D.: A comparison review of key epidemiological studies in cervical cancer related to current searches for transmissible agents. Cancer Res. 33, 1353–1367 (1973)

    PubMed  CAS  Google Scholar 

  • Rous, P., Beard, J.W.: The progression to carcinoma of virus-induced rabbit papillomas (Shope) J. Exp. Med. 62, 523–548 (1935)

    PubMed  CAS  Google Scholar 

  • Rous, P., Kidd, J.G., Smith, W.E.: Experiments on the cause of the rabbit carcinomas derived from virus-induced papillomas. J. Exp. Med. 96, 159–174 (1953)

    Google Scholar 

  • Rowson, K.E.K., Mahy, B.W.J.: Human papova (wart) virus. Bacteriol. Rev. 31, 110–131 (1967)

    PubMed  CAS  Google Scholar 

  • Ruiter, M.: On malignant degeneration of skin lesions in epidermodysplasia verruciformis. Acta Derm. Venereol. (Stockh.) 49, 309–313 (1969)

    CAS  Google Scholar 

  • Ruiter, M.: On the histomorphology and origin of malignant cutaneous changes in epidermodysplasia verruciformis. Acta Derm. Venerol. (Stockh.) 53, 290–298 (1973)

    CAS  Google Scholar 

  • Ruiter, M., Van Mullem, P. J.: Behaviour of virus in malignant degeneration of skin lesions in epidermodysplasia verruciformis. J. Invest. Dermatol. 54, 324–331 (1970a)

    PubMed  CAS  Google Scholar 

  • Ruiter, M., Van Mullem, P.J.: Further histological investigations on malignant degeneration of cutaneous lesions in epidermodysplasia verruciformis. Acta Derm. Venerol. (Suppl.) 50, 205–211 (1970 b)

    CAS  Google Scholar 

  • Rutledge, F., Sinclair, M.: Treatment of intraepithelial carcinoma of the vulva by skin excision and graft. Am. J. Obst. Gynec. 102, 806–818 (1968)

    Google Scholar 

  • Samitz, M.H., Ackermann, H.B., Lantis, L.R.: Squamous cell carcinoma arising at the site of oral florid papillomatosis. Arch. Dermatol. 96, 286–289 (1967)

    PubMed  CAS  Google Scholar 

  • Schellender, F., Fritsch, P.: Epidermodysplasia verruciformis. Neue Aspekte zur Symptomatologie und Pathogenese. Dermatologica 140, 251–259 (1970)

    Google Scholar 

  • Schmauz, R., Jain, D.: Geographical variation of carcinoma of the penis in Uganda. Br. J. Cancer 25, 25–32 (1971)

    PubMed  CAS  Google Scholar 

  • Schmauz, R., Findlay, M., Katsumbira, N., Lalwak, A., Buxton, E.: Assessment of verrucous carcinoma in an African series of cases of carcinoma of the penis. Cancer, in press (1977)

    Google Scholar 

  • Schoenberg, B.S., Greenberg, R.A., Eisenberg, H.: Occurrence of certain multiple primary cancers in females. J. Natl. Cancer Inst. 42, 15–32 (1969)

    Google Scholar 

  • Shelley, W.B.: An unusual autoimmune syndrome. A follow-up with reference to breast hypertrophy, systemic lupus erythematosus and verrucae. Acta Derm. Venereol. (Stockh.) 52, 33–37 (1972)

    CAS  Google Scholar 

  • Shirodaria, P. V., Matthews, R.S.: An immunofluorescence study of warts. Clin. Exp. Immunol. 21, 329–338 (1975)

    PubMed  CAS  Google Scholar 

  • Shope, R.E.: Infectious papillomatosis of rabbits; with a note on the histophatology. J. Exp. Med. 68, 607–624 (1933)

    Google Scholar 

  • Siegel, A.: Malignant transformation of condyloma acuminatum. Am. J. Surg. 103, 613–617 (1962)

    PubMed  CAS  Google Scholar 

  • Sims, C.F., Garb, J.: Giant condylomata acuminata of the penis associated with metastatic carcinoma of the right inguinal lymph node. Arch. Derm. (Chicago) 63, 383–385 (1951)

    CAS  Google Scholar 

  • Sobye, P.: Carcinoma penis, Phimose und Condylome. Acta Derm. Venerol. 35, 216–218 (1955)

    Google Scholar 

  • Sonck, C.E.: Condylomata acuminata mit Übergang in Karzinom. Z. Hautkr. 46, 273–278 (1971)

    CAS  Google Scholar 

  • Spencer, E.S., Andersen, H.K: Clinical evident non-terminal infections with herpesviruses and the wart virus in immunosuppressed renal allograft patients. Br. Med. J. 3, 251–254 (1970)

    PubMed  CAS  Google Scholar 

  • Spira, G., Estes, M.K., Dreesman, G.R., Butel, J.S., Rawls, W.E.: Papova virus structural polypeptides: Comparison of human and rabbit papilloma viruses with Simian Virus 40. Intervirology 3, 220–231 (1974)

    PubMed  CAS  Google Scholar 

  • Starzl, T.E., Porter, K.A., Andres, G., Halgrimson, C.G., Hurwitz, R., Giles, G., Terasaki, P.J., Penn, J., Schroter, G.T., Lilliy, J., Starkie, S.J., Putnam, C.W.: Long-term survival after renal transplantation in humans. Ann. Surg. 172, 437–172 (1970)

    PubMed  CAS  Google Scholar 

  • Strauss, M.J., Bunting, H., Melnick, J.L.: Virus-like particles and inclusion bodies in skin papillomas. J. Invest. Dermatol. 15, 433–443 (1950)

    PubMed  CAS  Google Scholar 

  • Strauss, M.J., Bunting, H., Melnick, J.L.: Eosinophilic inclusion bodies and cytoplasmic masses in verrucae. J. Invest. Dermatol. 17, 209–211 (1951)

    PubMed  CAS  Google Scholar 

  • Sturm, J. T.: Squamous cell carcinoma of the anus arising in a giant condyloma acuminatum: report of a case. Dis. Colon Rectum 18, 147–151 (1975)

    PubMed  CAS  Google Scholar 

  • Stutman, O.: Immunodeficiency states and natural resistance. In: Viruses and Immunity. Koprowski, C., Koprowski, H. (eds.). New York: Academic Press 1975, pp. 1–16

    Google Scholar 

  • Swerdlow, D.B., Salvati, E.P.: Condyloma acuminatum. Dis. Colon Rectum 14, 226–230 (1971)

    PubMed  CAS  Google Scholar 

  • Tajima, M., Gordon, D.E., Olson, C.: Electron microscopy of bovine papilloma and deer fibroma viruses. Am. J. Vet. Res. 29, 1185–1197 (1968)

    PubMed  CAS  Google Scholar 

  • Teokharov, B.A.: On the problem of the nature and epidemiology of acuminate condyloma- tosis. Vestn. Dermatol. Venerol. 36, 51–56 (1962)

    PubMed  CAS  Google Scholar 

  • Thivolet, J., Perrot, H., Michel, F., Bey vin, A.J.: Condylome acumine géant: maladie de Busche-Loewenstein. Lyon Méd. 221, 1027–1028 (1969)

    PubMed  CAS  Google Scholar 

  • Thomas, M., Boiron, M., Tanzer, J., Levy, J.P., Bernard, J.: In vitro transformation of mice cells by bovine papilloma virus. Nature (Lond.) 202, 709–710 (1964)

    CAS  Google Scholar 

  • Toso, G.: Epithelial papillomas—benign or malignant? Interesting finding in laryngeal papilloma. Laryngoscope 81, 1524–1531 (1971)

    PubMed  CAS  Google Scholar 

  • Touraine, A.: Epithéliomas et États Pré-Épithéliomateux. Paris: Masson 1961

    Google Scholar 

  • Treite, P.: Über die Karzinomentstehung auf spitzen Kondylomen. Zentralbl. Gynaekol. 65, 1096–1100 (1941)

    Google Scholar 

  • Ulimann, E.V.: On the aetiology of the laryngeal papilloma. Acta Oto-Laryngol. 5, 317–334 (1923)

    Google Scholar 

  • Underwood, P.B., Hester, L.L.: Diagnosis and treatment of premalignant lesions of the vulva: a review. Am. J. Obstet. Gynecol. 110, 849–857 (1971)

    PubMed  Google Scholar 

  • Vechet, R.: Auf Grund von Condylomata acuminata entstandenes Vulvacarcinom. Acta Gynaecol. Brunensis Clin. II., 2, 218–221 (1956)

    Google Scholar 

  • Vlodyka, J.: The cancerogenic effect of X-ray on the larynx. Arch. Otolaryngol. 76, 372–376 (1962)

    Google Scholar 

  • Waeisch, L., Habermann, S.: Über Warzen und spitze Kondylome. Arch. Dermatol. Syph. 147, 144–154 (1924)

    Google Scholar 

  • Walker-Davies, S.: A further case of Buschke-Loewenstein tumour. Giant condyloma of the penis. Br. J. Surg. 51, 338–339 (1964)

    Google Scholar 

  • Walsh, T.E., Beamer, P.R.: Epidermoid carcinoma of the larynx accurring in 2 children with papilloma of the larynx. Laryngoscope 60, 1110–1124 (1960)

    Google Scholar 

  • Waugh, M.: Condyloma acuminata. Br. Med. J. 2, 527–528 (1972)

    PubMed  CAS  Google Scholar 

  • Wolf, F.: In die Tiefe wuchernde spitze Condylome und Carcinom in demselben Penis- Tumor. Z. Hautkr. 13, 142–144 (1952)

    CAS  Google Scholar 

  • Woodruff, J.D., Peterson, W.F.: Condylomata acuminata of the cervix. Am. J. Obstet. Gynecol. 75, 1354–1362 (1958)

    PubMed  CAS  Google Scholar 

  • Yabe, Y., Koyama, H.: Virus and carcinogenesis in epidermodysplasia verruciformis. Gann 64, 167–172 (1973)

    PubMed  CAS  Google Scholar 

  • Yabe, Y., Sadakane, B.S.: The virus of epidermodysplasia verruciformis: electron microscopic and fluorescent antibody studies. J. Invest. Dermatol. 65, 324–330 (1975)

    PubMed  CAS  Google Scholar 

  • Yabe, Y., Okamoto, T., Okmori, S., Tanioku, K.: Virus particles in epidermodysplasia verruciformis with carcinoma. Dermatologica 139, 161–164 (1969)

    PubMed  CAS  Google Scholar 

  • Yoshiike, K., Defendi, V.: Homogeneity of human wart virus DNA. ASM Abstr. (Suppl.) 28, 209 (1976)

    Google Scholar 

  • Young, H.M.: Viral warts in the anorectum possibly precluding rectal cancer. Surgery 55, 367–380 (1964)

    PubMed  CAS  Google Scholar 

  • Zehnder, P.R., Lyons, G.D.: Carcinoma and juvenile papillomatosis. Ann. Otol. Rhinol. Laryngol. 84, 614–618 (1975)

    PubMed  Google Scholar 

  • Ziegler, A.: Condylomata acuminata mit tumorartigem Wachstum. Zbl. Haut- u. Geschl.- Kr. 25, 173–177 (1928)

    Google Scholar 

  • zur Hausen, H.: Oncogenic herpesviruses. Biophys. Biochim. Acta 417, 25–53 (1975)

    Google Scholar 

  • zur Hausen, H.: Condylomata acuminata and human genital cancer. Cancer Res. 36, 530 (1976)

    Google Scholar 

  • zur Hausen, H., Meinhof, W., Schreiber, W., Bornkamm, G.W.: Attempts to detect virus- specific DNA sequences in human tumors: I. Nucleic acid hybridizations with complementary RNA of human wart virus. Int. J. Cancer 13, 650–656 (1974)

    PubMed  Google Scholar 

  • zur Hausen, H., Gissmann, L., Steiner, W., Dippold, W., Dreger, J.: Human papilloma viruses and cancer. Bibl. Haematol. 43, 569–571 (1975)

    PubMed  Google Scholar 

  • Zurhelle, E.: Über die Anfangsformen des Peniscarcinoms. Dermatol. Wochenschr. 105, 1367–1372 (1937)

    Google Scholar 

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  1. Institut für Virologie, Zentrum für Hygiene, Universität Freiburg, D-7800, Hermann-Herder-Str. 11, Freiburg, Federal Republic of Germany

    Harald zur Hausen

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zur Hausen, H. (1977). Human Papillomaviruses and Their Possible Role in Squamous Cell Carcinomas. In: Arber, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 78. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66800-5_1

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