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Lessons from Research Innovations in Depression and HIV in Low- and Middle-Income Countries

Innovations in Global Mental Health

Abstract

Antiretroviral therapy has transformed HIV into a manageable disease, preventing the progression of HIV to AIDS and improving quality of life for people living with HIV. Increasing the number of people who test for HIV, initiating people living with HIV on antiretroviral therapy, and supporting them to adhere to their regimen have become central goals to the global strategy to end AIDS by 2030. Although we have seen extraordinary achievements, we are not on track to achieve these goals. People living with HIV face considerable emotional and social challenges which are known to adversely impact on their capacity to engage fully with HIV care and to maintain adherence to HIV medication. Among formally diagnosed mental disorders in people living with HIV, depression has received the most attention. However, in many settings where HIV is endemic, there is no single word for depression and emotional responses may be seen as “weakness” and something to be hidden (Aggarwal et al., Int J Soc Psychiatr 62(2):198–200, 2016). Sub-Saharan Africa carries the highest burden of HIV and has limited numbers of trained mental health care professionals. This chapter describes the global challenges to reducing new infections and HIV related deaths and illustrates innovative ways in which depression can be treated alongside HIV to allow people living with HIV to benefit from antiretroviral therapy and maintain healthy survival. Examples of innovations from sub-Saharan Africa provide evidence to support the urgent need for integrating mental health care into primary HIV services.

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References

  • Abas M, Bowers T, Manda E, Cooper S, Machando D, Verhey R, et al. ‘Opening up the mind’: problem-solving therapy delivered by female lay health workers to improve access to evidence-based care for depression and other common mental disorders through the Friendship Bench Project in Zimbabwe. Int J Ment Heal Syst. 2016;10(1):1–8.

    Article  Google Scholar 

  • Abas M, Nyamayaro P, Bere T, Saruchera E, Mothobi N, Simms V, et al. Feasibility and acceptability of a task-shifted intervention to enhance adherence to HIV medication and improve depression in people living with HIV in Zimbabwe, a low income country in Sub-Saharan Africa. AIDS Behav. 2018;22(1):86–101.

    Article  PubMed  Google Scholar 

  • Adams JL, Almond ML, Ringo EJ, Shangali WH, Sikkema KJ. Feasibility of nurse-led antidepressant medication management of depression in an HIV clinic in Tanzania. Int J Psychiatry Med. 2012;43(2):105–17.

    Article  PubMed  PubMed Central  Google Scholar 

  • Amare T, Getinet W, Shumet S, Asrat B. Prevalence and associated factors of depression among PLHIV in Ethiopia: systematic review and meta-analysis, 2017. AIDS Res Treat. 2018;2018:9.

    Google Scholar 

  • Andersen LS, Magidson JF, O'Cleirigh C, Remmert JE, Kagee A, Leaver M, et al. A pilot study of a nurse-delivered cognitive behavioral therapy intervention (Ziphamandla) for adherence and depression in HIV in South Africa. J Health Psychol. 2018;23(6):776–87.

    Article  PubMed  Google Scholar 

  • Baeten JM, Donnell D, Mugo NR, Ndase P, Thomas KK, Campbell JD, et al. Single-agent tenofovir versus combination emtricitabine plus tenofovir for pre-exposure prophylaxis for HIV-1 acquisition: an update of data from a randomised, double-blind, phase 3 trial. Lancet Infect Dis. 2014;14(11):1055–64.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Beck AT, Rush J, Shaw B, Emery G. Cognitive therapy of depression. New York: Guilford; 1979.

    Google Scholar 

  • Bell AC, D'Zurilla TJ. Problem-solving therapy for depression: a meta-analysis. Clin Psychol Rev. 2009;29(4):348–53.

    Article  PubMed  Google Scholar 

  • Bere T, Nyamayaro P, Magidson J, Chibanda D, Chingono A, O’Cleirgh C, et al. Cultural adaptation of a cognitive-behavioural intervention to improve adherence to antiretroviral therapy among people living with HIV/AIDS in Zimbabwe: Nzira Itsva. J Health Psychol. 2016;22:1265.

    Article  PubMed  PubMed Central  Google Scholar 

  • Bernard C, Dabis F, de Rekeneire N. Prevalence and factors associated with depression in people living with HIV in sub-Saharan Africa: a systematic review and meta-analysis. PLoS One. 2017;12(8):e0181960.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Betancourt TS, Rubin-Smith JE, Beardslee WR, Stulac SN, Fayida I, Safren S. Understanding locally, culturally, and contextually relevant mental health problems among Rwandan children and adolescents affected by HIV/AIDS. AIDS Care. 2011;23(4):401–12.

    Article  PubMed  PubMed Central  Google Scholar 

  • Betancourt T, Scorza P, Meyers-Ohki S, Mushashi C, Kayiteshonga Y, Binagwaho A, et al. Validating the center for epidemiological studies depression scale for children in Rwanda. J Am Acad Child Adolesc Psychiatry. 2012;51(12):1284–92.

    Article  PubMed  PubMed Central  Google Scholar 

  • Brandt R. The mental health of people living with HIV/AIDS in Africa: a systematic review. Afr J AIDS Res. 2009;8(2):123–33.

    Article  PubMed  Google Scholar 

  • Breslau N, Davis GC, Andreski P, Peterson E. Traumatic events and posttraumatic stress disorder in an urban population of young adults. Arch Gen Psychiatry. 1991;48(3):216–22.

    Article  CAS  PubMed  Google Scholar 

  • Breuer E, Myer L, Struthers H, Joska JA. HIV/AIDS and mental health research in sub-Saharan Africa: a systematic review. Afr J AIDS Res. 2011;10(2):101–22.

    Article  PubMed  Google Scholar 

  • Cha E, Erlen JA, Kim KH, Sereika SM, Caruthers D. Mediating roles of medication-taking self-efficacy and depressive symptoms on self-reported medication adherence in persons with HIV: a questionnaire survey. Int J Nurs Stud. 2008;45(8):1175–84.

    Article  PubMed  Google Scholar 

  • Chibanda D, Mangezi W, Tshimanga M, Woelk G, Rusakaniko S, Stranix-Chibanda L, et al. Postnatal depression by HIV status among women in Zimbabwe. J Womens Health (Larchmt). 2010a;19(11):2071–7.

    Article  Google Scholar 

  • Chibanda D, Mangezi W, Tshimanga M, Woelk G, Rusakaniko P, Stranix-Chibanda L, et al. Validation of the Edinburgh postnatal depression scale among women in a high HIV prevalence area in urban Zimbabwe. Arch Womens Ment Health. 2010b;13(3):201–6.

    Article  PubMed  Google Scholar 

  • Chibanda D, Cowan F, Gibson L, Weiss HA, Lund C. Prevalence and correlates of probable common mental disorders in a population with high prevalence of HIV in Zimbabwe. BMC Psychiatry. 2016a;16:55.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chibanda D, Gibson L, Weiss HA, Munjoma R, Araya R, Abas M. Validation of screening tools for depression and anxiety disorders in a primary care population with high HIV prevalence in Zimbabwe. J Affect Disord. 2016b;198:50–5.

    Article  PubMed  Google Scholar 

  • Christopher G, MacDonald J. The impact of clinical depression on working memory. Cogn Neuropsychiatry. 2005;10(5):379–99.

    Article  PubMed  Google Scholar 

  • Ciesla JA, Roberts JE. Meta-analysis of the relationship between HIV infection and risk for depressive disorders. Am J Psychiatry. 2001;158(5):725–30.

    Article  CAS  PubMed  Google Scholar 

  • Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365(6):493–505.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Croome N, Ahluwalia M, Hughes LD, Abas M. Patient-reported barriers and facilitators to antiretroviral adherence in sub-Saharan Africa. AIDS. 2017;31(7):995–1007.

    Article  PubMed  Google Scholar 

  • Gonzalez JS, Batchelder AW, Psaros C, Safren SA. Depression and HIV/AIDS treatment nonadherence: a review and meta-analysis. J Acquir Immune Defic Syndr. 2011;58(2):181–7. https://doi.org/10.1097/QAI.0B013E31822D490A.

    Article  PubMed  Google Scholar 

  • Grant RM, Lama JR, Anderson PL, McMahan V, Liu AY, Vargas L, et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med. 2010;363(27):2587–99.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Harrigan PR, Hogg RS, Dong WW, Yip B, Wynhoven B, Woodward J, et al. Predictors of HIV drug-resistance mutations in a large antiretroviral-naive cohort initiating triple antiretroviral therapy. J Infect Dis. 2005;191(3):339–47.

    Article  CAS  PubMed  Google Scholar 

  • Harrison A, Colvin CJ, Kuo C, Swartz A, Lurie M. Sustained high HIV incidence in young women in Southern Africa: social, behavioral, and structural factors and emerging intervention approaches. Curr HIV/AIDS Rep. 2015;12(2):207–15.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hawk ST. Disclosures of maternal HIV infection to seronegative children: a literature review. J Soc Pers Relat. 2007;24(5):657–73.

    Article  Google Scholar 

  • Horne R, Cooper V, Gellaitry G, Date HL, Fisher M. Patients’ perceptions of highly active antiretroviral therapy in relation to treatment uptake and adherence: the utility of the necessity-concerns framework. J Acquir Immune Defic Syndr. 2007;45(3):334–41.

    PubMed  Google Scholar 

  • Hughes E, Bassi S, Gilbody S, Bland M, Martin F. Prevalence of HIV, hepatitis B, and hepatitis C in people with severe mental illness: a systematic review and meta-analysis. Lancet Psychiatry. 2016;3(1):40–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Javadi D, Feldhaus I, Mancuso A, Ghaffar A. Applying systems thinking to task shifting for mental health using lay providers: a review of the evidence. Glob Ment Health (Cambridge, England). 2017;4:e14.

    Article  CAS  Google Scholar 

  • Jenkins R, Kydd R, Mullen P, Thomson K, Sculley J, Kuper S, et al. International migration of doctors, and its impact on availability of psychiatrists in low and middle income countries. PLoS One. 2010;5(2):e9049.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kagee A, Remien R, Berkman A, Hoffman S, Campos L, Swartz L. Structural barriers to ART adherence in Southern Africa: challenges and potential ways forward. Glob Public Health. 2011;6(1):83–97.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Katon W, Kleinman A, Rosen G. Depression and somatization: a review: part I. Am J Med. 1982;72(1):127–35.

    Article  CAS  PubMed  Google Scholar 

  • Kelly JD, Hartman C, Graham J, Kallen MA, Giordano TP. Social support as a predictor of early diagnosis, linkage, retention, and adherence to HIV care: results from the steps study. J Assoc Nurses AIDS Care. 2014;25(5):405–13.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kidia K, Machando D, Bere T, Macpherson K, Nyamayaro P, Potter L, et al. ‘I was thinking too much’: experiences of HIV-positive adults with common mental disorders and poor adherence to antiretroviral therapy in Zimbabwe. Tropical Med Int Health. 2015;20(7):903–13.

    Article  Google Scholar 

  • Kidia K, Machando D, Mangezi W, Hendler R, Crooks M, Abas M, et al. Mental health in Zimbabwe: a health systems analysis. Lancet Psychiatry. 2017;4:876.

    Article  PubMed  Google Scholar 

  • Kleinman A. Culture and depression. N Engl J Med. 2004;351(10):951–3.

    Article  CAS  PubMed  Google Scholar 

  • Langebeek N, Gisolf EH, Reiss P, Vervoort SC, Hafsteinsdottir TB, Richter C, et al. Predictors and correlates of adherence to combination antiretroviral therapy (ART) for chronic HIV infection: a meta-analysis. BMC Med. 2014;12:142.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Leserman J. HIV disease progression: depression, stress, and possible mechanisms. Biol Psychiatry. 2003;54(3):295–306.

    Article  PubMed  Google Scholar 

  • Leserman J, Petitto JM, Perkins DO, Folds JD, Golden RN, Evans DL. Severe stress, depressive symptoms, and changes in lymphocyte subsets in human immunodeficiency virus – infected men: a 2-year follow-up study. Arch Gen Psychiatry. 1997;54(3):279–85.

    Article  CAS  PubMed  Google Scholar 

  • Martinez A, Israelski D, Walker C, Koopman C. Posttraumatic stress disorder in women attending human immunodeficiency virus outpatient clinics. AIDS Patient Care STDs. 2002;16(6):283–91.

    Article  PubMed  Google Scholar 

  • Maughan-Brown B, Kenyon C, Lurie MN. Partner age differences and concurrency in South Africa: implications for HIV-infection risk among young women. AIDS Behav. 2014;18(12):2469–76.

    Article  PubMed  PubMed Central  Google Scholar 

  • McCormack S, Dunn DT, Desai M, Dolling DI, Gafos M, Gilson R, et al. Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial. Lancet. 2016;387(10013):53–60.

    Article  PubMed  PubMed Central  Google Scholar 

  • McPake B, Mensah K. Task shifting in health care in resource-poor countries. Lancet. 2008;372(9642):870–1.

    Article  PubMed  Google Scholar 

  • Mehrotra ML, Glidden DV, McMahan V, Amico KR, Hosek S, Defechereux P, et al. The effect of depressive symptoms on adherence to daily oral PrEP in men who have sex with men and transgender women: a marginal structural model analysis of the iPrEx OLE study. AIDS Behav. 2016;20(7):1527–34.

    Article  PubMed  PubMed Central  Google Scholar 

  • Michie S, van Stralen MM, West R. The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Implement Sci. 2011;6:42.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mills E, Nachega J, Bangsberg D, Singh S, Rachlis B, Wu P, et al. Adherence to HAART: a systematic review of developed and developing nation patient-reported barriers and facilitators. PLoS Med. 2006;3(11):e438.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mimiaga MJ, O’Cleirigh C, Biello KB, Robertson AM, Safren SA, Coates TJ, et al. The effect of psychosocial syndemic production on 4-year HIV incidence and risk behavior in a large cohort of sexually active men who have sex with men. J Acquir Immune Defic Syndr. 2015;68(3):329–36.

    Article  PubMed  PubMed Central  Google Scholar 

  • Molina J-M, Capitant C, Spire B, Pialoux G, Cotte L, Charreau I, et al. On-demand preexposure prophylaxis in men at high risk for HIV-1 infection. N Engl J Med. 2015;373(23):2237–46.

    Article  CAS  PubMed  Google Scholar 

  • Moriarty K, Genberg B, Norman B, Reece R. The effect of antiretroviral stock-outs on medication adherence among patients living with HIV in Ghana: a qualitative study. J Assoc Nurses AIDS Care. 2018;29(2):231–40.

    Article  PubMed  Google Scholar 

  • Nakimuli-Mpungu E, Wamala K, Okello J, Alderman S, Odokonyero R, Musisi S, et al. Developing a culturally sensitive group support intervention for depression among HIV infected and non-infected Ugandan adults: a qualitative study. J Affect Disord. 2014a;163:10–7.

    Article  PubMed  Google Scholar 

  • Nakimuli-Mpungu E, Wamala K, Okello J, Alderman S, Odokonyero R, Mojtabai R, et al. Outcomes, feasibility and acceptability of a group support psychotherapeutic intervention for depressed HIV affected Ugandan adults: a pilot study. J Affect Disord. 2014b;166:144–50.

    Article  PubMed  Google Scholar 

  • Nakimuli-Mpungu E, Wamala K, Okello J, Alderman S, Odokonyero R, Mojtabai R, et al. Group support psychotherapy for depression treatment in people with HIV/AIDS in northern Uganda: a single-centre randomised controlled trial. Lancet HIV. 2015;2:e190.

    Article  PubMed  Google Scholar 

  • Nduna M, Jewkes RK, Dunkle KL, Shai NP, Colman I. Associations between depressive symptoms, sexual behaviour and relationship characteristics: a prospective cohort study of young women and men in the Eastern Cape, South Africa. J Int AIDS Soc. 2010;13:44.

    Article  PubMed  PubMed Central  Google Scholar 

  • Olley BO, Zeier MD, Seedat S, Stein DJ. Post-traumatic stress disorder among recently diagnosed patients with HIV/AIDS in South Africa. AIDS Care. 2005;17(5):550–7.

    Article  CAS  PubMed  Google Scholar 

  • Onu C, Ongeri L, Bukusi E, Cohen CR, Neylan TC, Oyaro P, et al. Interpersonal psychotherapy for depression and posttraumatic stress disorder among HIV-positive women in Kisumu, Kenya: study protocol for a randomized controlled trial. Trials. 2016;17:64.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Opiyo E, Ongeri L, Rota G, Verdeli H, Neylan T, Meffert S. Collaborative interpersonal psychotherapy for HIV-positive women in Kenya: a case study from the mental health, HIV and domestic violence (MIND) study. J Clin Psychol. 2016;72(8):779–83.

    Article  PubMed  PubMed Central  Google Scholar 

  • Patel V, Simunyu E, Gwanzura F, Lewis G, Mann A. The Shona symptom questionnaire: the development of an indigenous measure of common mental disorders in Harare. Acta Psychiatr Scand. 1997;95:469.

    Article  CAS  PubMed  Google Scholar 

  • Patel V, Abas M, Broadhead J, Todd C, Reeler A. Depression in developing countries: lessons from Zimbabwe. BMJ. 2001;322(7284):482–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pence BW, Mills JC, Bengtson AM, et al. Association of increased chronicity of depression with hiv appointment attendance, treatment failure, and mortality among hiv-infected adults in the united states. JAMA Psychiat. 2018;75(4):379–85.

    Article  Google Scholar 

  • Perdue T, Hagan H, Thiede H, Valleroy L. Depression and HIV risk behavior among Seattle-area injection drug users and young men who have sex with men. AIDS Educ Prev. 2003;15(1):81–92.

    Article  PubMed  Google Scholar 

  • Petersen I, Bhana A, Baillie K. The feasibility of adapted group-based interpersonal therapy (IPT) for the treatment of depression by community health workers within the context of task shifting in South Africa. Community Ment Health J. 2012;48(3):336–41.

    Article  CAS  PubMed  Google Scholar 

  • Petersen I, Hanass Hancock J, Bhana A, Govender K. A group-based counselling intervention for depression comorbid with HIV/AIDS using a task shifting approach in South Africa: a randomized controlled pilot study. J Affect Disord. 2014;158:78–84.

    Article  CAS  PubMed  Google Scholar 

  • Quinn TC, Wawer MJ, Sewankambo N, Serwadda D, Li C, Wabwire-Mangen F, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. N Engl J Med. 2000;342(13):921–9.

    Article  CAS  PubMed  Google Scholar 

  • Rane MS, Hong T, Govere S, Thulare H, Moosa MY, Celum C, et al. Depression and anxiety as risk factors for delayed care-seeking behavior in HIV positive individuals in South Africa. Clin Infect Dis. 2018;67:1411.

    Article  PubMed  PubMed Central  Google Scholar 

  • Reisner SL, Mimiaga MJ, Skeer M, Bright D, Cranston K, Isenberg D, et al. Clinically significant depressive symptoms as a risk factor for HIV infection among black MSM in Massachusetts. AIDS Behav. 2009;13(4):798–810.

    Article  PubMed  PubMed Central  Google Scholar 

  • Rivera-Rivera Y, Vazquez-Santiago FJ, Albino E, Sanchez MD, Rivera-Amill V. Impact of depression and inflammation on the progression of HIV disease. J Clin Cell Immunol. 2016;7(3):423.

    Google Scholar 

  • Rodger A, Bruun T, Cambiano V, Vernazza P, Estrada V, Van Lunzen J. HIV transmission risk through condomless sex if HIV+ partner on suppressive ART: PARTNER study. Conference on retroviruses and opportunistic infections, 3–6 March 2014. Boston; 2014.

    Google Scholar 

  • Rodger A, Cambiano V, Bruun T, Vernazza P, Collins S, Corbelli GM, et al., editors. Risk of HIV transmission through condomless sex in MSM couples with suppressive ART: the PARTNER2 Study extended results in gay men. AIDS 2018; 2018. Amsterdam.

    Google Scholar 

  • Rogers G, Curry M, Oddy J, Pratt N, Beilby J, Wilkinson D. Depressive disorders and unprotected casual anal sex among Australian homosexually active men in primary care. HIV Med. 2003;4(3):271–5.

    Article  CAS  PubMed  Google Scholar 

  • Safren SA, Otto MW, Worth JL. Life-steps: applying cognitive behavioral therapy to HIV medication adherence. Cogn Behav Pract. 1999;6(4):332–41.

    Article  Google Scholar 

  • Safren SA, Otto MW, Worth JL, Salomon E, Johnson W, Mayer K, et al. Two strategies to increase adherence to HIV antiretroviral medication: life-steps and medication monitoring. Behav Res Ther. 2001;39(10):1151–62.

    Article  CAS  PubMed  Google Scholar 

  • Safren SA, O’Cleirigh C, Judy T, Raminani S, Reilly LC, Otto MW, et al. A randomized controlled trial of cognitive behavioral therapy for adherence and depression (CBT-AD) in HIV-infected individuals. Health Psychol. 2009;28:1–10.

    Article  PubMed  PubMed Central  Google Scholar 

  • Safren SA, Bedoya CA, O’Cleirigh C, Biello KB, Pinkston MM, Stein MD, et al. Cognitive behavioural therapy for adherence and depression in patients with HIV: a three-arm randomised controlled trial. Lancet HIV. 2016;3(11):e529–e38.

    Article  PubMed  PubMed Central  Google Scholar 

  • Saxena S, Thornicroft G, Knapp M, Whiteford H. Resources for mental health: scarcity, inequity, and inefficiency. Lancet. 2007;370(9590):878–89.

    Article  PubMed  Google Scholar 

  • Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatr. 1998;59(Suppl 20):22–33;quiz 4-57

    Google Scholar 

  • Simoni J, Chen W, Huh D, Fredriksen-Goldsen K, Pearson C, Zhao H, et al. A preliminary randomized controlled trial of a nurse-delivered medication adherence intervention among HIV-positive outpatients initiating antiretroviral therapy in Beijing, China. AIDS Behav. 2011;15(5):919–29.

    Article  PubMed  PubMed Central  Google Scholar 

  • Simoni JM, Yang JP, Shiu CS, Chen WT, Udell W, Bao M, et al. Nurse-delivered counselling intervention for parental HIV disclosure: results from a pilot randomized controlled trial in China. AIDS. 2015;29(Suppl 1):S99–s107.

    Article  PubMed  Google Scholar 

  • Sin NL, DiMatteo MR. Depression treatment enhances adherence to antiretroviral therapy: a meta-analysis. Ann Behav Med. 2014;47(3):259–69.

    Article  PubMed  Google Scholar 

  • Steel Z, Marnane C, Iranpour C, Chey T, Jackson JW, Patel V, et al. The global prevalence of common mental disorders: a systematic review and meta-analysis 1980–2013. Int J Epidemiol. 2014;43(2):476–93.

    Article  PubMed  PubMed Central  Google Scholar 

  • Stewart RC, Umar E, Tomenson B, Creed F. Validation of screening tools for antenatal depression in Malawi–a comparison of the Edinburgh postnatal depression scale and self reporting questionnaire. J Affect Disord. 2013;150(3):1041–7.

    Article  PubMed  Google Scholar 

  • Tao J, Vermund SH, Qian HZ. Association between depression and antiretroviral therapy use among people living with HIV: a meta-analysis. AIDS Behav. 2018;22(5):1542–50.

    Article  PubMed  PubMed Central  Google Scholar 

  • Taylor SW, Psaros C, Pantalone DW, Tinsley J, Elsesser SA, Mayer KH, et al. “Life-steps” for PrEP adherence: demonstration of a CBT-based intervention to increase adherence to preexposure prophylaxis (PrEP) medication among sexual-minority men at high risk for HIV acquisition. Cogn Behav Pract. 2017;24(1):38–49.

    Article  PubMed  PubMed Central  Google Scholar 

  • The INSIGHT START Study Group. Initiation of antiretroviral therapy in early asymptomatic HIV infection. N Engl J Med. 2015;373(9):795–807.

    Article  PubMed Central  CAS  Google Scholar 

  • Tsai AC. Reliability and validity of depression assessment among persons with HIV in sub-Saharan Africa: systematic review and meta-analysis. JAIDS. 2014;66(5):503–11.

    PubMed  Google Scholar 

  • UNAIDS. 90-90-90: An ambitious treatment target to help end the AIDS epidemic. 2014.

    Google Scholar 

  • UNAIDS. Ending AIDS: progress towards the 90–90–90 targets. Geneva: Joint United Nations Programme on HIV/AIDS (UNAIDS); 2017.

    Google Scholar 

  • UNAIDS. Miles to go – closing gaps, breaking barriers, righting injustices. Global AIDS update 2018. Geneva: Joint United Nations Programme on HIV/AIDS (UNAIDS); 2018.

    Google Scholar 

  • Vreeman RC, McCoy BM, Lee S. Mental health challenges among adolescents living with HIV. J Int AIDS Soc. 2017;20(Suppl 3):21497.

    PubMed  PubMed Central  Google Scholar 

  • Wagner GJ, Ngo V, Glick P, Obuku EA, Musisi S, Akena D. INtegration of DEPression treatment into HIV care in Uganda (INDEPTH-Uganda): study protocol for a randomized controlled trial. Trials. 2014;15(1):1.

    Article  CAS  Google Scholar 

  • Wagner GJ, Ngo V, Goutam P, Glick P, Musisi S, Akena D. A structured protocol model of depression care versus clinical acumen: a cluster randomized trial of the effects on depression screening, diagnostic evaluation, and treatment uptake in Ugandan HIV clinics. PLoS One. 2016;11(5):e0153132.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wainberg M, Dixon L. Ending HIV, hepatitis B, and hepatitis C: what about people with severe mental illness? Lancet Psychiatry. 2017;4(9):651–3.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang T, Fu H, Kaminga AC, Li Z, Guo G, Chen L, et al. Prevalence of depression or depressive symptoms among people living with HIV/AIDS in China: a systematic review and meta-analysis. BMC Psychiatry. 2018;18(1):160.

    Article  PubMed  PubMed Central  Google Scholar 

  • Weinhardt L. HIV diagnosis and risk behavior. In: Kalichman SC, editor. Positive prevention: reducing HIV transmission among people living with HIV/AIDS. New York: Kluwer; 2005.

    Google Scholar 

  • Weiser S, Wolfe W, Bangsberg D, Thior I, Gilbert P, Makhema J, et al. Barriers to antiretroviral adherence for patients living with HIV infection and AIDS in Botswana. J Acquir Immune Defic Syndr. 2003;34(3):281–8.

    Article  PubMed  Google Scholar 

  • Weissman M, Markowitz J, Klerman G. Clinician’s quick guide to interpersonal psychotherapy. Oxford: Oxford University Press; 2007.

    Book  Google Scholar 

  • WHO. mhGAP intervention guide. Mental Health Gap Action Programme. Version 2.0. 2016.

    Google Scholar 

  • World Healh Organisation. Task shifting to tackle health worker shortages. Geneva: World Healh Organisation; 2007.

    Google Scholar 

  • World Health Organization. mhGAP mental health gap action programme: scaling up care for mental, neurological and substance use disorders. Geneva: WHO; 2008.

    Google Scholar 

  • Yang JP, Xie T, Simoni JM, Shiu CS, Chen WT, Zhao H, et al. A mixed-methods study supporting a model of Chinese parental HIV disclosure. AIDS Behav. 2016;20(1):165–73.

    Article  PubMed  PubMed Central  Google Scholar 

  • Zhou Y, Zhang L, Li X, Kaljee L. Do Chinese parents with HIV tell their children the truth? A qualitative preliminary study of parental HIV disclosure in China. Child Care Health Dev. 2013;39(6):816–24.

    CAS  PubMed  Google Scholar 

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Jopling, R., Yang, J.P., Meffert, S., Müller, M., Nyamayaro, P.C., Abas, M. (2019). Lessons from Research Innovations in Depression and HIV in Low- and Middle-Income Countries. In: Okpaku, S. (eds) Innovations in Global Mental Health. Springer, Cham. https://doi.org/10.1007/978-3-319-70134-9_6-1

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    Lessons from Research Innovations in Depression and HIV in Low- and Middle-Income Countries
    Published:
    29 January 2021

    DOI: https://doi.org/10.1007/978-3-319-70134-9_6-2

  2. Original

    Lessons from Research Innovations in Depression and HIV in Low- and Middle-Income Countries
    Published:
    25 April 2019

    DOI: https://doi.org/10.1007/978-3-319-70134-9_6-1