Historical Background
The Src homology region 2 (SH) domain-containing protein tyrosine phosphatase-1 (SHP-1) is a member of the large family of protein tyrosine phosphatase (PTP). SHP-1 was identified in hematopoietic cells and organs involved in immune responses such as the spleen, thymus, lymph node, and bone marrow. SHP-1 is also known as hematopoietic cell phosphatase (HCP) because of its expression in these cells. Herein the nomenclature SHP-1 will be used. Back to the beginning of the 1990s, the study of tyrosine kinases was very well advanced; however, knowledge about their natural counterpart the tyrosine phosphatases was still greatly unraveled. Early on, different research groups isolated and identified a protein that contains two...
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Shio, M.T., Olivier, M. (2018). PTPN6. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_309
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DOI: https://doi.org/10.1007/978-3-319-67199-4_309
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