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Polo-Like Kinase (PLK)

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 89 Accesses

Synonyms

CaCdc5 (PLK in Candida albicans); Cdc5 (PLK in Saccharomyces cerevisiae); Plk1/SmPlk1; Plk4/SmSak (PLKs in Schistosoma mansoni); PLK1; PLK2/hSNK; PLK3/PRK; PLK4/SAK; PLK5 (PLKs in Homo sapiens); Plk1; Plk2/SNK; PLK3/FNK; Plk4 and Plk5 (PLKs in Mus musculus); plk1; plk2; plk3; ZYG-1 (PLKs in Caenorhabditis elegans); PLK1; PLK2; PLK4/SAK (PLKs in Strongylocentrotus purpuratus); plk1; plk2b; plk3; plk4 (PLKs in Danio rerio); PLKA (PLK in Aspergillus nidulans); plo1 (PLK in Schizosaccharomyces pombe); Plx1; Plx2; Plx3 (PLK in Xenopus laevis); TbPLK (PLK in Trypanosoma brucei).

Historical Background

Different protein kinases govern the progression of cell cycle by the phosphorylation of an array of their respective substrates. The key cell cycle kinases are polo-like kinase (PLK), cyclin-dependent kinase (CDK), and aurora kinases (AURK), which are evolutionarily conserved in eukaryotes from yeast to humans (Vaid et al. 2016). Polo-like kinases are serine/threonine kinases...

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References

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Author notes

  1. Nitin Sharma and Rajni Vaid have been contributed equally

Authors and Affiliations

  1. Faculty of Applied Sciences and Biotechnology, Shoolini University, Solan, Himachal Pradesh, 173212, India

    Nitin Sharma, Rajni Vaid, Kamal Dev & Anuradha Sourirajan

Authors
  1. Nitin Sharma
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  2. Rajni Vaid
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  3. Kamal Dev
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  4. Anuradha Sourirajan
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Corresponding author

Correspondence to Anuradha Sourirajan .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Sharma, N., Vaid, R., Dev, K., Sourirajan, A. (2018). Polo-Like Kinase (PLK). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101760

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