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Engineering of the Bladder and Urethra

  • Living reference work entry
  • First Online:
Organ Tissue Engineering

Part of the book series: Reference Series in Biomedical Engineering ((TIENRE))

  • 87 Accesses

Abstract

Many conditions can damage the lower urinary tract tissues, including trauma, inflammation, cancer, and congenital anomaly. Unfortunately, reconstruction of the human bladder and urethra remains a great urological challenge. This is due to the limited availability of tissue substitutes that can be used for reconstruction. Consequently, the use of intestinal tissue has remained as the gold standard for bladder reconstruction and repair, despite the associated complications, such as mucus production, electrolyte imbalances, recurrent infections, and malignancies. Similarly, the option for urethral tissue reconstruction is also limited. The autologous buccal mucosa is the most widely used material currently; however, donor site morbidity and stricture recurrence are continued problems. Tissue engineering has been introduced as a promising solution to repair and reconstruct lower urinary tract tissues, including the bladder and urethra. Clinical translation of tissue-engineered products has made significant progress in developing tangible therapies and inspiring the next generation of medical science over recent decades. Cell-based tissue engineering approaches have been employed to treat bladder and urethral pathologies in patients, demonstrating that multicellular tissues and organs with complex functions can be built for clinical use. This chapter covers the recent advancements in tissue engineering in the lower urinary tract tissues. Specifically, we discuss the strategic approaches, components used, supporting technologies, and tissue applications of the bladder and urethra.

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Author information

Authors and Affiliations

  1. Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston Salem, NC, USA

    Xian Lin Yi, Diana Lim, Anthony Atala & James J. Yoo

  2. Department of Urology, Tumor Hospital of GuangXi Medical University, Nanning, China

    Xian Lin Yi

Authors
  1. Xian Lin Yi
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  2. Diana Lim
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  3. Anthony Atala
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  4. James J. Yoo
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Corresponding author

Correspondence to James J. Yoo .

Editor information

Editors and Affiliations

  1. Klinik für Urologie, NORD1 B200, Universitäts Spital, Zürich, Zürich, Switzerland

    Daniel Eberli

  2. Institute for Regenerative Medicine, Wake Forest University, Winston Salem, NC, USA

    Sang Jin Lee

  3. Inst of Tendon and Bone Regeneration, Paracelsus Medical University, Salzburg, Austria

    Andreas Traweger

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Yi, X.L., Lim, D., Atala, A., Yoo, J.J. (2021). Engineering of the Bladder and Urethra. In: Eberli, D., Lee, S.J., Traweger, A. (eds) Organ Tissue Engineering. Reference Series in Biomedical Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-030-18512-1_1-1

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  • DOI: https://doi.org/10.1007/978-3-030-18512-1_1-1

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  • Print ISBN: 978-3-030-18512-1

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