Synonyms
Historical Background
Although the importance of follicle-stimulating hormone (FSH) in the reproduction has been well recognized for many years, FSH receptor (FSHR) had not been identified until 1970. High-affinity, low-capacity binding sites for FSH were demonstrated in 1972 using rat testicular tubules incubated with radiolabeled FSH (Simoni et al. 1997). In the following years, FSHR was identified, isolated, and purified in several species and cellular localization, ligand-receptor interaction, and intracellular signaling were studied extensively. FSHR gene was cloned in 1990 by screening rat Sertoli cell cDNA library. Since then, FSHR/Fshr has been cloned in several species ranging from human to reptile (Simoni et al. 1997). These findings led to identification of FSHR mutations and polymorphisms that either enhance (activating or gain-of-function mutation) or impair (inactivating or loss-of-function mutation) the function of the receptor (Lussiana et...
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Araujo VR, Gastal MO, Figueiredo JR, Gastal EL. In vitro culture of bovine preantral follicles: a review. Reprod Biol Endocrinol. 2014;12:78. https://doi.org/10.1186/1477-7827-12-78.
Arey BJ, Lopez FJ. Are circulating gonadotropin isoforms naturally occurring biased agonists? Basic and therapeutic implications. Rev Endocr Metab Disord. 2011;12:275–88. https://doi.org/10.1007/s11154-011-9188-y.
Ayoub MA, Landomiel F, Gallay N, Jegot G, Poupon A, Crepieux P, Reiter E. Assessing gonadotropin receptor function by resonance energy transfer-based assays. Front Endocrinol (Lausanne). 2015;6:130. https://doi.org/10.3389/fendo.2015.00130.
Banerjee AA, Mahale SD. Role of the extracellular and intracellular loops of follicle-stimulating hormone receptor in its function. Front Endocrinol (Lausanne). 2015;6:110. https://doi.org/10.3389/fendo.2015.00110.
Bose CK. Follicle stimulating hormone receptor in ovarian surface epithelium and epithelial ovarian cancer. Oncol Res. 2008;17:231–8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18980020
Davis JS, Kumar TR, May JV, Bousfield GR. Naturally occurring follicle-stimulating hormone glycosylation variants. J Glycomics Lipidomics. 2014;4:e117. https://doi.org/10.4172/2153-0637.1000e117.
Desai SS, Roy BS, Mahale SD. Mutations and polymorphisms in fsh receptor: functional implications in human reproduction. Reproduction. 2013;146:R235–48. https://doi.org/10.1530/REP-13-0351.
Ensembl. Transcript: FSHR-001 (ENST00000406846.6). 2016. http://uswest.ensembl.org/Homo_sapiens/Transcript/Exons?db=core;g=ENSG00000170820;r=2:49189296-49381676;t=ENST00000406846. Accessed 1 Oct 2016.
Feng X, Zhang M, Guan R, Segaloff DL. Heterodimerization between the lutropin and follitropin receptors is associated with an attenuation of hormone-dependent signaling. Endocrinology. 2013;154:3925–30. https://doi.org/10.1210/en.2013-1407.
Gartrell BA, Tsao CK, Galsky MD. The follicle-stimulating hormone receptor: a novel target in genitourinary malignancies. Urol Oncol. 2013;31:1403–7. https://doi.org/10.1016/j.urolonc.2012.03.005.
George JW, Dille EA, Heckert LL. Current concepts of follicle-stimulating hormone receptor gene regulation. Biol Reprod. 2011;84:7–17. https://doi.org/10.1095/biolreprod.110.085043.
Ginther OJ. The theory of follicle selection in cattle. Domest Anim Endocrinol. 2016;57:85–99. https://doi.org/10.1016/j.domaniend.2016.06.002.
Gloaguen P, Crepieux P, Heitzler D, Poupon A, Reiter E. Mapping the follicle-stimulating hormone-induced signaling networks. Front Endocrinol (Lausanne). 2011;2:45. https://doi.org/10.3389/fendo.2011.00045.
Hermann BP, Heckert LL. Transcriptional regulation of the fsh receptor: new perspectives. Mol Cell Endocrinol. 2007;260–262:100–8. https://doi.org/10.1016/j.mce.2006.09.005.
Jiang X, Dias JA, He X. Structural biology of glycoprotein hormones and their receptors: insights to signaling. Mol Cell Endocrinol. 2014;382:424–51. https://doi.org/10.1016/j.mce.2013.08.021.
Kang DS, Tian X, Benovic JL. Role of beta-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking. Curr Opin Cell Biol. 2014;27:63–71. https://doi.org/10.1016/j.ceb.2013.11.005.
Kumar TR. What have we learned about gonadotropin function from gonadotropin subunit and receptor knockout mice? Reproduction. 2005;130:293–302. https://doi.org/10.1530/rep.1.00660. [pii] 130/3/2 93.
Kumar TR. Extragonadal fsh receptor: is it real? Biol Reprod. 2014;91:99. https://doi.org/10.1095/biolreprod.114.124222.
Landomiel F, Gallay N, Jegot G, Tranchant T, Durand G, Bourquard T, Crepieux P, Poupon A, Reiter E. Biased signalling in follicle stimulating hormone action. Mol Cell Endocrinol. 2014;382:452–9. https://doi.org/10.1016/j.mce.2013.09.035.
Lussiana C, Guani B, Mari C, Restagno G, Massobrio M, Revelli A. Mutations and polymorphisms of the fsh receptor (fshr) gene: clinical implications in female fecundity and molecular biology of fshr protein and gene. Obstet Gynecol Surv. 2008;63:785–95. https://doi.org/10.1097/OGX.0b013e31818957eb. [pii] 0006254-200812000-00021.
McGee EA, Raj RS. Regulators of ovarian preantral follicle development. Semin Reprod Med. 2015;33:179–84. https://doi.org/10.1055/s-0035-1552584.
Minegishi T. Regulation of gonadotropin receptor in ovary. In: Leung PCK, Adashi EY, editors. The ovary. 2nd ed. San Diego: Elsevier Academic Press; 2004. p. 79–92.
Nataraja SG, Yu HN, Palmer SS. Discovery and development of small molecule allosteric modulators of glycoprotein hormone receptors. Front Endocrinol (Lausanne). 2015;6:142. https://doi.org/10.3389/fendo.2015.00142.
Papadimitriou K, Kountourakis P, Kottorou AE, Antonacopoulou AG, Rolfo C, Peeters M, Kalofonos HP. Follicle-stimulating hormone receptor (fshr): a promising tool in oncology? Mol Diagn Ther. 2016;20:523–30. https://doi.org/10.1007/s40291-016-0218-z.
Ramaswamy S, Weinbauer GF. Endocrine control of spermatogenesis: role of fsh and lh/ testosterone. Spermatogenesis. 2014;4:e996025. https://doi.org/10.1080/21565562.2014.996025.
Shenoy SK, Lefkowitz RJ. Beta-arrestin-mediated receptor trafficking and signal transduction. Trends Pharmacol Sci. 2011;32:521–33. https://doi.org/10.1016/j.tips.2011.05.002.
Siegel ET, Kim HG, Nishimoto HK, Layman LC. The molecular basis of impaired follicle-stimulating hormone action: evidence from human mutations and mouse models. Reprod Sci. 2013;20:211–33. https://doi.org/10.1177/1933719112461184.
Simoni M, Casarini L. Mechanisms in endocrinology: genetics of fsh action: a 2014-and-beyond view. Eur J Endocrinol. 2014;170:R91–107. https://doi.org/10.1530/EJE-13-0624.
Simoni M, Gromoll J, Nieschlag E. The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology. Endocr Rev. 1997;18:739–73 .http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9408742
Ulloa-Aguirre A, Zarinan T, Pasapera AM, Casas-Gonzalez P, Dias JA. Multiple facets of follicle-stimulating hormone receptor function. Endocrine. 2007;32:251–63. https://doi.org/10.1007/s12020-008-9041-6.
Ulloa-Aguirre A, Zarinan T. The follitropin receptor: matching structure and function. Mol Pharmacol. 2016;90:596–608. https://doi.org/10.1124/mol.116.104398.
Ulloa-Aguirre A, Crepieux P, Poupon A, Maurel MC, Reiter E. Novel pathways in gonadotropin receptor signaling and biased agonism. Rev Endocr Metab Disord. 2011;12:259–74. https://doi.org/10.1007/s11154-011-9176-2.
UniProtKB/Swiss-Prot. P23945 (FSHR_HUMAN). 2016. http://www.uniprot.org/uniprot/P23945. Accessed 1 Oct 2016.
Vassart G, Pardo L, Costagliola S. A molecular dissection of the glycoprotein hormone receptors. Trends Biochem Sci. 2004;29:119–26. https://doi.org/10.1016/j.tibs.2004.01.006. [pii] S0968000404000234.
Wang J, Zhang W, Yu C, Zhang X, Zhang H, Guan Q, Zhao J, Xu J. Follicle-stimulating hormone increases the risk of postmenopausal osteoporosis by stimulating osteoclast differentiation. PLoS One. 2015;10:e0134986. https://doi.org/10.1371/journal.pone.0134986.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this entry
Cite this entry
Tetsuka, M., Matsui, M., Shimizu, T. (2018). Follicle Stimulating Hormone Receptor (FSHR). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_585
Download citation
DOI: https://doi.org/10.1007/978-3-319-67199-4_585
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-67198-7
Online ISBN: 978-3-319-67199-4
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences