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Multiple facets of follicle-stimulating hormone receptor function

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Abstract

Follicle-stimulating hormone (FSH) is a glycoprotein hormone produced by the anterior pituitary gland. This gonadotropin plays an essential role in reproduction. Its receptor (FSHR) belongs to the superfamily of G protein-coupled receptors (GPCR), specifically the family of rhodopsin-like receptors. Agonist binding to the FSHR triggers the rapid activation of multiple signaling cascades, mainly the cAMP–adenylyl cyclase–protein kinase A cascade, that impact diverse biological effects of FSH in the gonads. As in other G protein-coupled receptors, the several cytoplasmic domains of the FSHR are involved in signal transduction and termination of the FSH signal. Here we summarize some recent information on the signaling cascades activated by FSH as well as on the role of the intracytoplasmic domains of the FSHR in coupling to membrane and cytosolic proteins linked to key biological functions regulated by the FSH–FSHR system.

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Acknowledgments

Studies performed in the authors’ laboratories have been supported by grants from the Consejo Nacional de Ciencia y Tecnología (CONACyT, Mexico) [Grants 45991M (to A.U.-A.) and P40673 (to A.M.P.)], the Fondo para el Fomento de la Investigación (FOFOI)-Instituto Mexicano del Seguro Social, Mexico (Grants 2006/1A/I/008, 2006/1A/I/042, and 2005/1/I/002 to A.U.-A), and the NIH, Bethesda, MD (Grant HD18407 to J.A.D.). Alfredo Ulloa-Aguirre is the recipient of a Research Career Development Award from the Fundación IMSS, México.

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Authors and Affiliations

  1. Research Unit in Reproductive Medicine, Hospital de Ginecobstetricia “Luis Castelazo Ayala”, Instituto Mexicano del Seguro Social, Apartado Postal 99-065, Unidad Independencia, C.P. 10101, Mexico, D.F., Mexico

    Alfredo Ulloa-Aguirre, Teresa Zariñán, Ana Ma. Pasapera & Patricia Casas-González

  2. Wadsworth Center, David Axelrod Institute for Public Health, NYSDOH, and Dept. Biomedical Sciences, State University of New York at Albany, Albany, NY, USA

    James A. Dias

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  1. Alfredo Ulloa-Aguirre
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  2. Teresa Zariñán
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  3. Ana Ma. Pasapera
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  4. Patricia Casas-González
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  5. James A. Dias
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Correspondence to Alfredo Ulloa-Aguirre.

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Ulloa-Aguirre, A., Zariñán, T., Pasapera, A.M. et al. Multiple facets of follicle-stimulating hormone receptor function. Endocr 32, 251–263 (2007). https://doi.org/10.1007/s12020-008-9041-6

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