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CD53

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

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Synonyms

CD53 antigen; CD53 tetraspanin antigen; Cell surface glycoprotein CD53; Leukocyte surface antigen CD53; MOX44; Ox-44; OX44; Tetraspanin-25; Tspan-25; Tspan25; TSPAN25

Historical Background

CD53 is a member of the tetraspanin family of hydrophobic membrane-spanning proteins. Tetraspanins form microdomains on the cell surface that can interact with many different proteins implicated in signaling forming vesicles leading to endosome and exosome formation. CD53 has no known extracellular ligand. The specific function of CD53 has not yet been defined, but CD53 has been shown to modulate cell adhesion, migration, cell proliferation, and survival. Ligation of CD53 with antibodies protects cells from apoptosis; this effect is mediated by phosphorylation and activation of Akt, increased levels of Bcl-Xl, decreasing the amount of Bax, and reducing caspase activation. In mesangial cells, CD53 ligation stimulates the induction of DNA synthesis via the MEK-ERK pathway. CD53 ligation...

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Author information

Authors and Affiliations

  1. Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Salamanca, Salamanca, Spain

    Pedro A. Lazo

  2. Instituto de Investigación Biomédica de Salamanca (IBSAL), Hospital Universitario de Salamanca, Salamanca, Spain

    Pedro A. Lazo

  3. Unidad de Patología Mamaria, Unidad Funcional de Investigación en Enfermedades Crónicas, Instituto de Salud Carlos III, E-28220, Majadahonda, Madrid, Spain

    Mónica Yunta

  4. Departamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad de Santiago de Compostela, E-27002, Lugo, Spain

    Ramiro Barcia

Authors
  1. Pedro A. Lazo
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  2. Mónica Yunta
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  3. Ramiro Barcia
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Corresponding author

Correspondence to Pedro A. Lazo .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Lazo, P.A., Yunta, M., Barcia, R. (2018). CD53. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_566

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