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Biogenesis of Medium-Chain-Length Polyhydroxyalkanoates

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Biogenesis of Fatty Acids, Lipids and Membranes

Part of the book series: Handbook of Hydrocarbon and Lipid Microbiology ((HHLM))

Abstract

Medium-chain-length polyhydroxyalkanoates (mcl-PHA) are biotechnologically useful natural products found in many bacteria. This biopolymer functions as a carbon and energy storage reservoir in cells but has physical and mechanical properties that make it a promising bioplastic with applications ranging from adhesives to medical implants. Therefore, there is much interest in understanding the biology of mcl-PHA synthesis and metabolism. Increased knowledge of PHA biology serves as a foundation for the bioengineering of PHA and its eventual use as a biologically derived product. This chapter covers the state of knowledge on mcl-PHA, including its synthesis and its central role in cellular metabolism. Moreover, this chapter discusses methods for bioengineering mcl-PHA production in bacteria as well as synthetic biology methods for its study and production in the natural mcl-PHA producer, Pseudomonas putida.

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Acknowledgments

Research on polymer biotechnology in the laboratory of M. Auxiliadora Prieto is supported by funding from the European Union’s Horizon 2020 research and innovation program under grant agreements number 633962 and 679050. We also acknowledge support from the Community of Madrid (P2013/MIT2807) and the Spanish Ministry of Economy (BIO201344878R, BIO2014-61515-EXP).

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  1. Department of Environmental Biology, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), 28040, Madrid, Spain

    Ryan Kniewel & M. Auxiliadora Prieto

  2. Bioprocess Laboratory D-BSSE, ETH Zürich, Mattenstrasse 26, 4058, Basel, Switzerland

    Olga Revelles Lopez

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  1. Ryan Kniewel
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  2. Olga Revelles Lopez
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  3. M. Auxiliadora Prieto
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Correspondence to M. Auxiliadora Prieto .

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  1. Centro de Ciencias Genomicas, Universidad Nacional Autonoma de Mexico Centro de Ciencias Genomicas, Cuernavaca, Morelos, Mexico

    Otto Geiger

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Kniewel, R., Revelles Lopez, O., Prieto, M. (2017). Biogenesis of Medium-Chain-Length Polyhydroxyalkanoates. In: Geiger, O. (eds) Biogenesis of Fatty Acids, Lipids and Membranes. Handbook of Hydrocarbon and Lipid Microbiology . Springer, Cham. https://doi.org/10.1007/978-3-319-43676-0_29-1

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