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MEG Imaged Pathways of Stuttering

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Magnetoencephalography

Abstract

Knowledge of the underlying mechanism of stuttering may be useful for finding the best individual treatment for this persistent disorder. Stuttering is a disruption in speech production, characterized by repetitions, blocks, and/or prolongations. MEG neuroimaging techniques provide an excellent tool for establishing and evaluating reliable protocols to detect the underlying mechanisms of stuttering which in the future will help clinicians assess responses to treatments. Detection of neuronal network abnormalities in the default mode network of patients who stutter can also provide further brain regions for evaluation of pre- and posttreatment. This chapter reviews the use of MEG in past and present studies of stuttering. Areas for future research and refinement of MEG protocols for stuttering are also presented.

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References

  • Ambrose NG, Yairi E (1999) Normative disfluency data for early childhood stuttering. J Speech Lang Hear Res 42:895–909

    Article  CAS  PubMed  Google Scholar 

  • Anderson JD, Pellowski MW, Conture EG, Kelly EM (2003) Temperamental characteristics of young children who stutter. J Speech Lang Hear Res 46(5):1221–1233

    Article  PubMed  Google Scholar 

  • Beal DS, Quraan MA, Cheyne DO, Taylor MJ, Gracco VL, De Nil LF (2011) Speech-induced suppression of evoked auditory fields in children who stutter. NeuroImage 54(4):2994–3003

    Article  PubMed  Google Scholar 

  • Bennett EM (2006) Working with people who stutter: a lifespan approach. Pearson Education Inc, Upper Saddle River

    Google Scholar 

  • Biermann-Ruben K, Salmelin R, Schnitzler A (2005) Right rolandic activation during speech perception in stutterers: a MEG study. NeuroImage 25(3):793–801

    Article  PubMed  Google Scholar 

  • Blomgren M (2010) Stuttering treatment for adults: an update on contemporary approaches. Semin Speech Lang 31(4):272–282

    Article  PubMed  Google Scholar 

  • Bloodstein O (1995) A handbook on stuttering. Singular Publishing Group, San Diego

    Google Scholar 

  • Bothe AK, Davidow JH, Bramlett RE, Franic DM, Ingham RJ (2006a) Stuttering treatment research 1970–2005: II. Systematic review incorporating trial quality assessment of pharmacological approaches. Am J Speech Lang Pathol 15(4):342–352

    Article  PubMed  Google Scholar 

  • Bothe AK, Davidow JH, Bramlett RE, Franic DM, Ingham RJ (2006b) Stuttering treatment research 1970–2005: I. Systematic review incorporating trial quality assessment of behavioral, cognitive, and related approaches. Am J Speech Lang Pathol 15(4):321–341

    Article  PubMed  Google Scholar 

  • Bowyer SM, Moran JE, Mason KM, Constantinou JE, Smith BJ, Barkley GL, Tepley N (2004) MEG localization of language-specific cortex utilizing MR-FOCUSS. Neurology 62(12):2247–2255

    Article  CAS  PubMed  Google Scholar 

  • Bowyer SM, Peacock J, Tepley N, Moran JE (2010) Neuronal effects of the SpeechEasy treatment for stuttering. In: 17th international conference on biomagnetism advances in biomagnetism—BIOMAG2010, vol 28. IFMBE, Dubrovnik, pp 342–345

    Chapter  Google Scholar 

  • Braun A, Varga M, Stager S, Schulz G, Selbie S, Maisog JM, Carson RE, Ludlow CL (1997) Altered patterns of cerebral activity during speech and language production in developmental stuttering. Brain 120:761–784

    Article  PubMed  Google Scholar 

  • Brown S, Ingham RJ, Ingham JC, Laird AR, Fox PT (2005) Stuttered and fluent speech production: an ALE meta-analysis of functional neuroimaging studies. Hum Brain Mapp 25:105–117

    Article  PubMed  PubMed Central  Google Scholar 

  • Chang S, Erickson KI, Ambrose NG, Hasegawa-Johnson MA, Ludlow CL (2008) Brain anatomy difference in childhood stuttering. NeuroImage 39(3):1333–1344

    Article  PubMed  Google Scholar 

  • Chang SE, Kenney MK, Loucks TMJ, Ludlow CL (2009) Brain activation abnormalities during speech and non-speech in stuttering speakers. NeuroImage 46(1):201–212

    Article  PubMed  Google Scholar 

  • Conture EG (1990) Childhood stuttering: what is it and who does it? ASHA Rep 18:2–14

    Google Scholar 

  • Conture EG, Kelly EM (1991) Young stutterers’ nonspeech behaviors during stuttering. J Speech Lang Hear Res 34:1041–1056

    Article  CAS  Google Scholar 

  • De Nil LF, Kroll RM (2001) Searching for the neural basis of stuttering treatment outcome: recent neuroimaging studies. Clin Linguis Phon 15:163–168

    Article  Google Scholar 

  • De Nil LF, Kroll RM, Kapur S, Houle S (2000) A positron emission tomography study of silent and oral single word reading in stuttering and nonstuttering adults. J Speech Lang Hear Res 43:1038–1053

    Article  PubMed  Google Scholar 

  • De Nil LF, Sasisekaran J, Van Lieshout PH, Sandor P (2005) Speech disfluencies in individuals with Tourette syndrome. J Psychosom Res 58(1):97–102

    Article  PubMed  Google Scholar 

  • De Nil LF, Beal DS, Lafaille SJ, Kroll RM, Crawley AP, Gracco VL (2008) The effects of simulated stuttering and prolonged speech on the neural activation patterns of stuttering and nonstuttering adults. Brain Lang 107(2):114–123

    Article  PubMed  Google Scholar 

  • Dell G (1986) A spreading activation theory of retrieval in sentence production. Psychol Rev 93:283–321

    Article  CAS  PubMed  Google Scholar 

  • Drayna D, Kang C (2011) Genetic approaches to understanding the causes of stuttering. J Neurodev Disord 3(4):374–380

    Article  PubMed  PubMed Central  Google Scholar 

  • Elisevich K, Shukla N, Moran JE, Smith BJ, Schultz L, Mason KM, Barkley GL, Tepley N, Gumenyuk V, Bowyer SM (2011) An assessment of MEG coherence imaging in the study of temporal lobe epilepsy. Epilepsia 52(6):1110–1119. PMID:21366556

    Article  PubMed  PubMed Central  Google Scholar 

  • Foundas AL, Bollich AM, Feldman J, Corey DM, Hurley M, Lemen LC, Heilman KM (2004) Aberrant auditory processing and atypical planum temporale in developmental stuttering. Neurology 63(9):1640–1646. PMID:15534249

    Article  CAS  PubMed  Google Scholar 

  • Fox MD, Raichle ME (2007) Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 8:700–711

    Article  CAS  PubMed  Google Scholar 

  • Fox PT, Ingham RJ, Ingham JC, Hirsch TB, Downs JH, Matrin C et al.(1996) A PET study of the neural systems of stuttering. Nature 382:158–161

    Article  CAS  PubMed  Google Scholar 

  • Fox PT, Ingham RJ, Ingham JC, Zamarripa F, Xiong J-H, Lancaster JL (2000) Brain correlates of stuttering and syllable production: a PET performance-correlation analysis. Brain 123:1985–2004

    Article  PubMed  Google Scholar 

  • Frazier L (1987) Theories of sentence processing. MIT Press, Cambridge

    Google Scholar 

  • Friederici A (1999) The neurobiology of language comprehension. Springer, Berlin

    Book  Google Scholar 

  • Friederici A (2002) Towards a neural basis of auditory sentence processing. Trends Cogn Sci 6:78–84

    Article  PubMed  Google Scholar 

  • Fromkin V (1971) The non-anomalous nature of anomalous utterances. Language 47:27–52

    Article  Google Scholar 

  • Garret M (1975) The analysis of sentence production. Academic, NewYork

    Book  Google Scholar 

  • Garrett M (1980) Levels of processing in sentence production. Academic, London

    Google Scholar 

  • Geschwind N (1970) The organization of language and the brain. Science 170(961):940–944

    Article  CAS  PubMed  Google Scholar 

  • Gordon N (2002) Stuttering: incidence and causes. Dev Med Child Neurol 44(4):278–281

    Article  PubMed  Google Scholar 

  • Greenwald M, Bowyer S (2003) MEG studies of speech production. Perspect Neurophysiol Neurogenic Speech Lang Disord 13(3):4–9

    Article  Google Scholar 

  • Guitar B (1998) Stuttering: an integrated approach to its nature and treatment. Williams & Wilkins, Baltimore

    Google Scholar 

  • Hagoort P (2003) How the brain solves the binding problem for language: a neurocomputational model of syntactic processing. NeuroImage 20:S18–S29

    Article  PubMed  Google Scholar 

  • Hari R, Levanen S et al.(2000) Timing of human cortical functions during cognition: role of MEG. Trends Cogn Sci 4(12):455–462

    Article  CAS  PubMed  Google Scholar 

  • Heim S (2005) The structure and dynamics of normal language processing: insights from neuroimaging. Acta Neurobiol Exp 65:95–116

    Google Scholar 

  • Helenius P, Salmelin R, Service E, Connolly JF (1998) Distinct time courses of word and context comprehension in the left temporal cortex. Brain 121.(Pt 6:1133–1142

    Article  PubMed  Google Scholar 

  • Hickok G (2009) The functional neuroanatomy of language. Phys Life Rev 6(3):121–143

    Article  PubMed  PubMed Central  Google Scholar 

  • Howell P (2004) Effects of delayed auditory feedback and frequency-shifted feedback on speech control and some potentials for future development of prosthetic aids for stammering. Stammering Res 1(1):31–46

    PubMed  PubMed Central  Google Scholar 

  • Howell P (2011) Listen to the lessons of The King’s Speech. Nature 470(7332):7

    Article  CAS  PubMed  Google Scholar 

  • Ingham RJ (2001) Brain imaging studies of developmental stuttering. J Commun Disord 34:493–516

    Article  CAS  PubMed  Google Scholar 

  • Ingham RJ, Fox PT, Ingham JC (2004) Brain correlates of stuttering and syllable production: gender comparison and replication. J Speech Lang Hear Res 47:321–341

    Article  PubMed  Google Scholar 

  • Kang C, Drayna D (2011) Genetics of speech and language disorders. Annu Rev Genomics Hum Genet 22(12):145–164

    Article  CAS  Google Scholar 

  • Kaplan PW, Stagg R (2011) Frontal lobe nonconvulsive status epilepticus: a case of epileptic stuttering, aphemia, and aphasia—not a sign of psychogenic nonepileptic seizures. Epilepsy Behav 21(2):191–195

    Article  PubMed  Google Scholar 

  • Kikuchi Y, Ogata K, Umesaki T, Yoshiura T, Kenjo M, Hirano Y, Okamoto T, Komune S, Tobimatsu S (2011) Spatiotemporal signatures of an abnormal auditory system in stuttering. NeuroImage 55(3):891–899

    Article  PubMed  Google Scholar 

  • Lan J, Song M, Pan C, Zhuang G, Wang Y, Ma W, Chu Q, Lai Q, Xu F, Li Y, Liu L, Wang W (2009) Association between dopaminergic genes (SLC6A3 and DRD2) and stuttering among Han Chinese. J Hum Genet 54(8):457–460

    Article  CAS  PubMed  Google Scholar 

  • Levelt W (1989) Speaking: from intention to articulation. MIT Press, Cambridge

    Google Scholar 

  • Levelt W (1998) The genetic perspective in psycholinguistics or where do spoken words come from? J Psycholinguist Res 27:167–180

    Article  Google Scholar 

  • Levelt WJ, Praamstra P, Meyer AS, Helenius P, Salmelin R (1998) An MEG study of picture naming. J Cogn Neurosci 10(5):553–567

    Article  CAS  PubMed  Google Scholar 

  • Levelt WJM, Roelofs A, Meyer AS (1999) A theory of lexical access in speech production. Behav Brain Sci 22:1–75

    CAS  PubMed  Google Scholar 

  • Liberman AM, Cooper FS, Shankweiler DP, Studdert-Kennedy M (1967) Perception of the speech code. Psychol Rev 74:431–461

    Article  CAS  PubMed  Google Scholar 

  • Liu Z, Ding L, He B (2006) Integration of EEG/MEG with MRI and fMRI. IEEE Eng Med Biol Mag 25(4):46–53

    Article  PubMed  PubMed Central  Google Scholar 

  • Loucks T, Kraft SJ, Choo AL, Sharma H, Ambrose NG (2011) Functional brain activation differences in stuttering identified with a rapid fMRI sequence. J Fluen Disord 36(4):302–307

    Article  Google Scholar 

  • Lu C, Chen C, Ning N, Ding G, Guo T, Peng D, Yang Y, Li K, Lin C (2010) The neural substrates for atypical planning and execution of word production in stuttering. Exp Neurol 221(1):146–156

    Article  PubMed  Google Scholar 

  • Ludlow CL (2000) Stuttering: dysfunction in a complex and dynamic system. Brain 123(10):1983–1984

    Article  PubMed  Google Scholar 

  • MacDermot KD, Bonora E, Sykes N, Coupe AM, Lai CS, Vernes SC, Vargha-Khadem F, McKenzie F, Smith RL, Monaco AP, Fisher SE (2005) Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits. Am J Hum Genet 76(6):1074–1080

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • MacKay D (1987) The organization of perception and action: a theory for language and other cognitive skills. Springer, New York

    Book  Google Scholar 

  • Maguire GA, Franklin DL, Kirsten J (2011) Asenapine for the treatment of stuttering: an analysis of three cases. Am J Psychiatry 168(6):651–652

    Article  PubMed  Google Scholar 

  • Marslen-Wilson WD, Tyler L (1980) The temporal structure of spoken language understanding. Cognition 8:1–71

    Article  CAS  PubMed  Google Scholar 

  • McClelland J (1991) Stochastic interactive processes and the effect of context on perception. Cogn Psychol 23:1–44

    Article  CAS  PubMed  Google Scholar 

  • McClelland JL, Elman J (1986) The TRACE model of speech perception. Cogn Psychol 18:1–86

    Article  CAS  PubMed  Google Scholar 

  • Moran JE, Bowyer S, Tepley N (2005) Multi-resolution FOCUSS: a source imaging technique applied to MEG data. Brain Topogr 18:1–17

    Article  CAS  PubMed  Google Scholar 

  • Movsessian P (2005) Neuropharmacology of theophylline induced stuttering: the role of dopamine, adenosine and GABA. Med Hypotheses 64(2):290–297

    Article  CAS  PubMed  Google Scholar 

  • Newbury DF, Monaco AP (2010) Genetic advances in the study of speech and language disorders. Neuron 68(2):309–320

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ratner NB (2010) Translating recent research into meaningful clinical practice. Semin Speech Lang 31(4):236–249

    Article  PubMed  Google Scholar 

  • Salmelin R (2007) Clinical neurophysiology of language: the MEG approach. Clin Neurophysiol 118(2):237–254

    Article  PubMed  Google Scholar 

  • Salmelin R, Schnitzler A, Schmitz F, Jäncke L, Witte OW, Freund HJ (1998) Functional organization of the auditory cortex is different in stutterers and fluent speakers. Neuroreport 9(10):2225–2229

    Article  CAS  PubMed  Google Scholar 

  • Salmelin R, Schnitzler A, Schmitz F, Freund H-J (2000) Single word reading in developmental stutterers and fluent speakers. Brain 123:1184–1202

    Article  PubMed  Google Scholar 

  • Shattuck-Hufnagel S (1979) Speech errors as evidence for a serial ordering mechanism in sentence production. Erlbaum, Hillside

    Google Scholar 

  • Shattuck-Hufnagel S (1987) The role of word-onset consonants in speech production planning: new evidence from speech error patterns. Erlbaum, Hillsdale

    Google Scholar 

  • Simos PG, Breier JI, Zouridakis G, Papanicolaou AC (1998) Identification of language-specific brain activity using magnetoencephalography. J Clin Exp Neuropsychol 20(5):706–722

    Article  CAS  PubMed  Google Scholar 

  • Simos PG, Castillo EM et al.(2001) Mapping of receptive language cortex in bilingual volunteers by using magnetic source imaging. J Neurosurg 95(1):76–81

    Article  CAS  PubMed  Google Scholar 

  • Stemberger J (1985) An interactive activation model of language production. Erlbaum, London

    Google Scholar 

  • Tarkianine A, Helenius P, Hansen PC, Cornelissen PL, Salmelin R (1999) Dynamics of letter sting perception in the human occipitotemporal cortex. Brain 122:2119–2132

    Article  Google Scholar 

  • Tavano A, Busan P, Borelli M, Pelamatti G (2011) Risperidone reduces tic-like motor behaviors and linguistic dysfluencies in severe persistent developmental stuttering. J Clin Psychopharmacol 31(1):131–134

    Article  PubMed  Google Scholar 

  • Theys C, van Wieringen A, De Nil LF (2008) A clinician survey of speech and non-speech characteristics of neurogenic stuttering. J Fluen Disord 33(1):1–23

    Article  Google Scholar 

  • Toyomura A, Fujii T, Kuriki S (2011) Effect of external auditory pacing on the neural activity of stuttering speakers. NeuroImage 57(4):1507–1516

    Article  PubMed  Google Scholar 

  • Van Borsel J, Tetnowski JA (2007) Fluency disorders in genetic syndromes. J Fluen Disord 32(4):279–296

    Article  Google Scholar 

  • Walla P, Mayer D, Deecke L, Thurner S (2004) The lack of focused anticipation of verbal information in stutterers: a magnetoencephalographic study. NeuroImage 22(3):1321–1327

    Article  PubMed  Google Scholar 

  • Watkins KE, Smith SM, Davis S, Howell P (2008) Structural and functional abnormalities of the motor system in developmental stuttering. Brain 131:50–59

    Article  PubMed  Google Scholar 

  • Weber-Fox C (2001) Neural systems for sentence processing in stuttering. J Speech Lang Hear Res 44:814–825

    Article  CAS  PubMed  Google Scholar 

  • Weber-Fox C, Spencer RMC, Spruill JE, Smith A (2004) Phonologic processing in adults who stutter: electrophysiological and behavioral evidence. J Speech Lang Hear Res 47:1244–1258

    Article  PubMed  Google Scholar 

  • Weber-Fox C, Spruill JE, Spencer R, Smith A (2008) Atypical neural functions underlying phonological processing and silent rehearsal in children who stutter. Dev Sci 11(2):321–337

    Article  PubMed  PubMed Central  Google Scholar 

  • World_Health_Organization (1992) International statistical classification of diseases and related health problems, 10th rev. ICD-10. World_Health_Organization, Geneva, p 387

    Google Scholar 

  • Xuan Y, Meng C, Yang Y, Zhu C, Wang L, Yan Q, Lin C, Yu C (2012) Resting-state brain activity in adult males who stutter. PLoS One 7(1):1–11

    Article  CAS  Google Scholar 

  • Yairi E (1993) The early months of stuttering: a developmental study. J Speech Lang Hear Res 36:521–528

    Article  CAS  Google Scholar 

  • Yairi E, Ambrose N, Cox N (1996) Genetics of stuttering: a critical review. J Speech Hear Res 39(4):771–784

    Article  CAS  PubMed  Google Scholar 

  • Zebrowski PM (1995) The topography of beginning stuttering. J Commun Disord 28(2):75–91

    Article  CAS  PubMed  Google Scholar 

  • Zebrowski P, Buhr A (eds) (2005) Straight talk on stuttering: information, encouragement, and counsel for stutterers, caregivers, and speech-language clinicians. J Fluen Disord 30(2):149–152

    Google Scholar 

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Correspondence to Susan M. Bowyer .

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Bowyer, S.M., Peacock, J. (2019). MEG Imaged Pathways of Stuttering. In: Supek, S., Aine, C. (eds) Magnetoencephalography. Springer, Cham. https://doi.org/10.1007/978-3-030-00087-5_38

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