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Handbook of Chemical Biology of Nucleic Acids

  • Living reference work
  • © 2022

Overview

Editors:
  1. Naoki Sugimoto

    1. Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, Kobe, Japan

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  • Commemorates the 70th anniversary of the DNA double helix discovery
  • Provides comprehensive coverage of fundamentals and applications of nucleic acids
  • Broadens the reader's understanding of nucleic acids

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Table of contents (90 entries)

  1. Advancing XNAzymes as Nucleic Acid Therapeutics

    • Yajun Wang, John C. Chaput

  2. Amides and Other Nonionic Backbone Modifications in RNA

    • Eriks Rozners

  3. Aptamer Molecular Evolution for Liquid Biopsy

    • Lingling Wu, Qi Niu, Chaoyong Yang

  4. Artificial Genetic Switches and DNA Origami: Current Landscape and Prospects as Designer Therapeutics and Visualization Tools

    • Ganesh N. Pandian, Shubham Mishra, Hiroshi Sugiyama

  5. Binding and Modulation of G-quadruplex DNA and RNA Structures by Proteins

    • Philipp Simon, Philipp Schult, Katrin Paeschke

  6. Biomaterials Based on DNA Conjugates and Assemblies

    • Kazunori Matsuura, Hiroshi Inaba

  7. Bridged Nucleic Acids for Therapeutic Oligonucleotides

    • Md Ariful Islam, Satoshi Obika

  8. Carbon Nanotubes and Nucleic Acids

    • Priyannth Ramasami Sundharbaabu, Junhyuck Chang, Jung Heon Lee

  9. Charge Transfer in Natural and Artificial Nucleic Acids

    • Sabine Müller, Jennifer Frommer

  10. Chemical Tools to Target Noncoding RNAs

    • Maurinne Bonnet, Maria Duca

  11. Chemical-Assisted Epigenome Sequencing

    • Dongsheng Bai, Jinying Peng, Chengqi Yi

  12. Chemistry of Cyclic Dinucleotides and Analogs

    • Noriko Saito-Tarashima, Noriaki Minakawa

  13. Compound Shape and Substituent Effects in DNA Minor Groove Interactions

    • W. David Wilson, Ananya Paul

  14. Controlled Intracellular Trafficking and Gene Silencing by Oligonucleotide-Signal Peptide Conjugates

    • Masayuki Fujii, Marija Krstic-Demonacos, Constantinos Demonacos

  15. Cross-Linking Duplex of Nucleic Acids with Modified Oligonucleotides

    • Fumi Nagatsugi

  16. Cyclic Naphthalene Diimide Derivatives as Novel DNA Ligands

    • Shigeori Takenaka

  17. Design and Biological Application of RTK Agonist Aptamers

    • Ryosuke Ueki, Shinsuke Sando

  18. Design and Self-Assembly of Therapeutic Nucleic Acid Nanoparticles (NANPs) with Controlled Immunological Properties

    • Morgan Chandler, Leyla Danai, Kirill A. Afonin

  19. Detection Systems Using the Ternary Complex Formation of Nucleic Acids

    • Hiroto Fujita, Masayasu Kuwahara

  20. DNA Damage and Repair in G-Quadruplexes Impact Gene Expression

    • Aaron M. Fleming, Cynthia J. Burrows
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Keywords

About this book

This handbook is the first to comprehensively cover nucleic acids from fundamentals to recent advances and applications. It is divided into 10 sections where authors present not only basic knowledge but also recent research. Each section consists of extensive review chapters covering the chemistry, biology, and biophysics of nucleic acids as well as their applications in molecular medicine, biotechnology and nanotechnology. All sections within this book are: Physical Chemistry of Nucleic Acids (Section Editor: Prof. Roland Winter), Structural Chemistry of Nucleic Acids (Section Editor: Prof. Janez Plavec), Organic Chemistry of Nucleic Acids (Section Editor: Prof. Piet Herdewijin), Ligand Chemistry of Nucleic Acids (Section Editor: Prof. Marie-Paule Teulade-Fichou), Nucleic Acids and Gene Expression (Section Editor: Prof. Cynthia Burrows), Analytical Methods and Applications of Nucleic Acids (Section Editor: Prof. Chaoyong Yang), Nanotechnology and Nanomaterial Biology of Nucleic Acids (Section Editor: Prof. Zhen Xi), Nucleic Acids Therapeutics (Section Editor: Prof. Katherine Seley-Radtke), Biotechnology and Synthetic Biology of Nucleic Acids (Section Editor: Prof. Eriks Rozners), Functional Nucleic Acids (Section Editor: Prof. Keith R. Fox).

The handbook is edited by outstanding leaders with contributions written by international renowned experts. It is a valuable resource not only for researchers but also graduate students working in areas related to nucleic acids who would like to learn more about their important role and potential applications. 

Editors and Affiliations

  • Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, Kobe, Japan

    Naoki Sugimoto

About the editor

Naoki Sugimoto received Ph.D. degree in 1985 from Kyoto University, Japan. After postdoctoral work at University of Rochester, USA, he joined Konan University, Kobe, Japan in 1988 and is a full professor since 1994. From 2003, he also holds a director of Frontier Institute for Biomolecular Engineering Research (FIBER) at Konan University. He is a member of the Editorial Board of Nucleic Acids Research from 2007 and Scientific Reports from 2015 to the present, was the first President of the Japan Society of Nucleic Acids Chemistry (JSNAC) from 2017 to 2020 and is now the Fellow of JSNAC. He received the Dr. Masao Horiba’s Award in 2004, Distinguished Scientist Award from ICA (International Copper Association), USA in 2005, Hyogo Science Award from Hyogo prefecture, Japan in 2006, the Chemical Society Japan (CSJ) Award for Creative Work in 2007, JSCC Contribution Award, Japan Society of Coordination Chemistry(JSCC) in 2014, The Iue Cultural Award in Science and Technology in 2015, The Imbach-Townsend Award, IS3NA in 2018, The 72th CSJ Award (Top Award in CSJ) in 2019, and so on. His research interests focus on biophysical chemistry, biomaterials, bionano-engineering, molecular design, biofunctional chemistry, biotechnology, and therapeutic application of nucleic acids.

Bibliographic Information

  • Book Title: Handbook of Chemical Biology of Nucleic Acids

  • Editors: Naoki Sugimoto

  • DOI: https://doi.org/10.1007/978-981-16-1313-5

  • Publisher: Springer Singapore

  • eBook Packages: Springer Reference Chemistry and Mat. Science, Reference Module Physical and Materials Science, Reference Module Chemistry, Materials and Physics

  • eBook ISBN: 978-981-16-1313-5Due: 23 July 2023

  • Number of Pages: X, 1990

  • Number of Illustrations: 10 b/w illustrations, 10 illustrations in colour

  • Topics: Chemistry/Food Science, general, Biomaterials, Biochemistry, general, Organic Chemistry, Biotechnology, Nanochemistry

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