Overview
Provides numerous but simple overviews of current topics in glycoscience
Some chapters include the current protocol for the experiments which include introduction, protocol, results and comments
Provides some unique and novel classifications in each chapter which include systems glycobiology, chemical glycobiology and glycoimmunology, etc. and are useful for medical applications
Includes supplementary material: sn.pub/extras
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About this book
The aim of the book is to provide a succinct overview of the current status of glycoscience from both basic biological and medical points of view and to propose future directions, in order to facilitate further integrations of glycoscience with other fields in biological and medical studies.
Glycans (carbohydrate oligomers) are the so-called “building blocks” of carbohydrates, nucleic acids, proteins and lipids and play major roles in many biological phenomena as well as in various pathophysiological processes. However, this area of glycoscience has been neglected from the research community because glycan structures are very complex and functionally diverse and as compared to proteins and nucleic acids simple tools for the amplification, sequencing and auto-synthesis of glycans are not available. Many scientists in other fields of research have now realized that glycosylation, i.e. the addition of glycans to a protein backbone, is the most abundant post translational modification reactions and is an important field of research and sometimes they require a glycobiology and/or glycochemistry approach to be used. It is still difficult, however, for non-expert researchers to use these techniques. This book provides numerous but simple overviews of current topics and protocols for the experiments. The book is aimed at university students and above, including non-experts in the field of glycoscience.
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Keywords
Table of contents (191 entries)
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O-GlcNAcylation: Central Role of O-GlcNAc in Metabolism
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Disease Glycomics and Glyco-Biomarkers: Implication of Glycans in Disease and Application for Biomarkers
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Role of Glycans in Cancer
Editors and Affiliations
About the editors
Naoyuki Taniguchi is working for RIKEN, Japan.
Tamao Endo is with Tokyo. Metropolitan Institute of Gerontology, Japan. Gerald Hart is with Johns Hopkins University, USA.
Peter Seeberger is with Max Planck Institute, Germany.
Chi-Huey Wong is with Academia Sinica, Taiwan.
The co-editors are Jin-ichi Inokuchi, Ken Kitajima, Shoko Nishihara, Yasuhiro Kajihara, Kenji Kadomatsu, Takashi Angata, and Yoshiki Yamaguchi.
Bibliographic Information
Book Title: Glycoscience: Biology and Medicine
Editors: Naoyuki Taniguchi, Tamao Endo, Gerald W. Hart, Peter H. Seeberger, Chi-Huey Wong
DOI: https://doi.org/10.1007/978-4-431-54841-6
Publisher: Springer Tokyo
eBook Packages: Biomedical and Life Sciences, Reference Module Biomedical and Life Sciences
Copyright Information: Springer Japan 2015
Hardcover ISBN: 978-4-431-54840-9Published: 14 November 2014
eBook ISBN: 978-4-431-54841-6Published: 30 October 2014
Edition Number: 1
Number of Pages: LXII, 1568
Number of Illustrations: 100 b/w illustrations, 233 illustrations in colour
Topics: Biochemistry, general, Cell Biology, Cancer Research