Abstract
AU-rich elements (AREs) are found in 3′ untranslated regions (3′ UTR) of many highly unstable mRNAs for mammalian early-response genes. The minimal AU sequence core within the ARE is the heptamer WAUUUAW, although from a functional point of view, several pentanucleotides clustered in close proximity are the key sequence motif that mediates mRNA degradation (1).
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Dominguez, O., Sabater, L., Ashhab, Y., Belloso, E., Pujol-Borrell, R. (2003). AU-Differential Display, Reproducibility of a Differential mRNA Display Targeted to AU Motifs. In: Bartlett, J.M.S., Stirling, D. (eds) PCR Protocols. Methods in Molecular Biology™, vol 226. Humana Press. https://doi.org/10.1385/1-59259-384-4:225
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DOI: https://doi.org/10.1385/1-59259-384-4:225
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