Abstract
Methylation of cytosine residues is an almost ubiquitous finding of higher organisms (1). The majority of this methylation occurs at the dinucleotide CpG (where p denotes a phosphate group) (2). CpG sites are distributed throughout the genome with clusters of the sequence being found in the 5′ promoter region of housekeeping genes, in groups known as CpG islands. These short stretches of DNA have a have a C and G base composition, which in mammals and avians is estimated to be 10 times higher than in bulk DNA (3)
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© 2002 Humana Press Inc.
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Davies, C.S. (2002). Methylation-Sensitive Restriction Fingerprinting. In: Mills, K.I., Ramsahoye, B.H. (eds) DNA Methylation Protocols. Methods in Molecular Biology™, vol 200. Springer, Totowa, NJ. https://doi.org/10.1385/1-59259-182-5:043
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DOI: https://doi.org/10.1385/1-59259-182-5:043
Publisher Name: Springer, Totowa, NJ
Print ISBN: 978-0-89603-618-5
Online ISBN: 978-1-59259-182-4
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