Abstract
The development of specific receptor inhibitors of angiotensin II and the generation of genetic knockout models of the different components of the renin-angiotensin-aldosterone (RAAS) cascade has confirmed previous and has created new evidence for elementary functions of the RAAS for the body.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Derkx, F. H., Steunkel, C., Schalekamp, M. P., Visser, W., Huisveld, I. H., and Schalekamp, M. A. (1986) Immunoreactive renin, prorenin, and enzymatically active renin in plasma during pregnancy and in women taking oral contraceptives. J. Clin. Endocrinol. Metab. 63, 1008–1015.
Simon, D., Badouaille, G., Pau, B., and Guyene, T. T., Corvol, P., Menard, J. (1987) Measurement of active renin by the 4G1 anti-human renin monoclonal antibody. Clin. Exp. Hypertens. A 9, 1333–1340.
Gross, R., Hackenberg, H. M., Hackenthal, E., and Kirchheim, H. (1981) Interaction between perfusion pressure and sympathetic nerves in renin release by carotid baroreflex in conscious dogs. J. Physiol. 313, 237–250.
Schurek, H. J. and Alt, J. M. (1981) Effect of albumin on the function of perfused rat kidney. Am. J. Physiol. 240, F569–F576.
Scholz, H., Kaissling, B., Inagami, T., and Kurtz, A. (1991) Differential response of renin secretion to vasoconstrictors in the isolated perfused rat kidney. J. Physiol. 441, 453–468.
Albinus, M., Finkbeiner, E., Sosath, B., and Osswald, H. (1998) Isolated superfused juxtaglomerular cells from rat kidney: a model for study of renin secretion. Am. J. Physiol. 275, F991–F997.
Della Bruna, R., Pinet, F., Corvol, P., and Kurtz, A. (1991) Regulation of renin secretion and renin synthesis by second messenger in isolated mouse juxtaglomerular cells. Cell Physiol. Biochem. 1, 98–110.
Della Bruna, R., Pinet, F., Corvol, P., and Kurtz, A. (1995) Opposite regulation of renin gene expression by cyclic AMP and calcium in isolated mouse juxtaglomerular cells. Kidney Int. 47, 1266–1273.
Carey, R. M., Geary, K. M., Hunt, M. K., Ramos, S. P., Forbes, M. S., Inagami, T., et al. (1990) Identification of individual renocortical cells that secrete renin. Am. J. Physiol. 258, F649–F659.
Everett, A. D., Carey, R. M., Chevalier, R. L., Peach, M. J., and Gomez, R. A. (1990) Renin release and gene expression in intact rat kidney microvessels and single cells. J. Clin. Invest. 86, 169–175.
Friis, U. G., Jensen, B. L., Aas, J. K., and Skott, O. (1999) Direct demonstration of exocytosis and endocytosis in single mouse juxtaglomerular cells. Circ. Res. 84, 929–936.
Kurtz, A., Kaissling, B., Busse, R., and Baier, W. (1991) Endothelial cells modulate renin secretion from isolated juxtaglomerular cells. J. Clin. Invest. 88, 1147–1154.
Sigmund, C. D., Okuyama K., Ingelfinger, J., Jones, C. A., Mullins, J. J., Kane, C., et al. (1990) Isolation and characterization of renin expressing cell lines from transgenic mice containing a renin promoter viral oncogene fusion construct. J. Biol. Chem. 265, 19,916–19,922.
Jones, C. A., Petrovic, N., Novak, E. K., Swank, R. T., Sigmund, C. D., and Gross, K. W. (1997) Biosynthesis of renin in mouse kidney tumor As4.1 cells. Eur. J. Biochem. 243, 181–190.
Petrovic, N., Kane, C. M., Sigmund, C. D., and Gross, K. W. (1997) Downregulation of renin gene expression by interleukin-1. Hypertension 30, 230–235.
Jensen, B. L., Lehle, U., Müller, M., Wagner, C., and Kurtz, A. (1998) Interleukin-1 inhibits renin gene expression in As4.1 cells but not in native juxtaglomerular cells. Eur. J. Physiol. 436, 673–678.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Humana Press Inc.
About this protocol
Cite this protocol
Kurtz, A., Schweda, F. (2001). Measuring Renin Secretion from Juxtaglomerular Cells. In: Wang, D.H. (eds) Angiotensin Protocols. Methods in Molecular Medicine™, vol 51. Humana Press. https://doi.org/10.1385/1-59259-087-X:391
Download citation
DOI: https://doi.org/10.1385/1-59259-087-X:391
Publisher Name: Humana Press
Print ISBN: 978-0-89603-763-2
Online ISBN: 978-1-59259-087-2
eBook Packages: Springer Protocols