Abstract
Electrochemotherapy (ECT) is a combination treatment which involves administering a chemotherapeutic agent followed by the delivery of electric pulses to cells or tissue. Electrical treatment results in increased drug uptake by the cells which provides an improved therapeutic benefit relative to using the drug alone. Increased drug uptake is due to a process that has been termed electropermeabilization, or electroporation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Chang, D. C., Saunders, J. A., Chassy, B. M., and Sowers, A. E. (1992) Guide to Electroporation and Electrofusion. Academic Press, San Diego, CA.
Teissié, J. and Rols, M. P. (1992) Time course of electropermeabilization, in Charge and Field Effects in Biosystems, Vol. 3 (Allen, M. J., Cleary, S. F., Sowers, A. E., and Shillady, D. D., eds.), Birkhauser, Boston, MA, pp. 285–301.
Heller, R., Jaroszeski, M., Leo-Messina, J., Perrott, R., Van Voorhis, N., Reintgen, D., and Gilbert, R. (1995) Treatment of B16 melanoma with the combinations of electroporation and chemotherapy. Bioelectrochem. Bioenerg. 36, 83–87.
Mir, L. M., Orlowski, S., Belehradek, J. Jr., and Paoletti, C. (1991) Electrochemotherapy potentiation of antitumour effect of bleomycin by local electric pulses. Eur. J. Cancer 27, 68–72.
Serša, G., Čemažar, M., and Miklavčič, D. (1995) Antitumor effectiveness of electrochemotherapy with cis-diamminedichloroplatinum (II) in mice. Cancer Res. 55, 3450–3455.
Kanesada, H. (1990) Anticancer effect of high voltage pulses combined with concentration dependent anticancer drugs on lewis lung carcinoma, in vivo. J. Jpn. Soc. Cancer Ther. 25, 2640–2648.
Belehradek, J. Jr., Orlowski, S., Poddevin, B., Paoletti, C., and Mir, L. M. (1991) Electrochemotherapy of spontaneous mammary tumors in mice. Eur. J. Cancer 27, 73–76.
Okino, M., Tomie, H., Kanesada, H., Marumoto, M., Morita, N., Esato, K., and Suzuki, H. (1991) Induction of tumor specific selective toxicity in electrical impulse chemotherapy-analysis of dose response curve. Oncologia 24, 71–79.
Salford, L. G., Persson, B. R. R., Brun, A., Ceberg, C. P., Kongstad, P. C. H., and Mir, L. M. (1993) An new brain tumour therapy combining bleomycin with in vivo electropermeabilization. Biochem. Biophys. Res. Commun. 194, 938–943.
Heller, R., Jaroszeski, M. J., Glass, L. F., Messina, J. L., Rapaport, D. P., DeConti, R. C., Fenske, N. A., Gilbert, R. A., Mir, L. M., and Reintgen, D. S. (1996) Phase I/II trial for the treatment of cutaneous and subcutaneous tumors using electrochemotherapy. Cancer 77, 964–971.
Heller, R. (1995) Treatment of cutaneous nodules using electrochemotherapy. J. Florida Med. Assoc. 82, 147–150.
Rudolf, Z., Stabuc, B., Čemažar, M., Miklavčič, D. Vodovnik, L., and Serša, G. (1995) Electrochemotherapy with bleomycin: The first clinical experience in malignant melanoma patients. Radiol. Oncol. 29, 229–235.
Glass, L. F., Fenske, N. A., Jaroszeski, M. J., Perrott, R., Harvey, D. T., Reintgen D. S., and Heller, R. (1996) Bleomycin-mediated electrochemotherapy of basal cell carcinoma. J. Am. Acad. Dermatol. 34, 82–86.
Mir, L. M., Belehradek, M., Domenge, C., Orlowski, S., Poddevin, J. Jr., Schwab, G., Luboinnski, B., and Paoletti, C. (1991) Electrochemotherapy, a novel antitumor treatment: First clinical trial. C. R. Acad. Sci. 313, 613–618.
Belehradek, M., Domenge, C., Luboinnski, B., Orlowski, S., Belehradek, J., and Mir, L. M. (1993) Electrochemotherapy, a new anticancer treatment. Cancer 72, 694–3700.
Domenge, C., Orlowski, S., Luboinski, B., DeBaere, T., Schwaab, G., Belehradek, Jr., and Mir, L. M. (1996) Antitumor electrochemotherapy. Cancer 77, 956–963.
Jaroszeski, M. J., Gilbert, R. A., and Heller, R. (1997) In vivo antitumor effects of lectrochemotherapy in a hepatoma model. Biochem. Biophys. Acta 1334, 15–18.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2000 Humana Press Inc.
About this protocol
Cite this protocol
Jaroszeski, M.J., Gilbert, R., Heller, R. (2000). Treatment of Liver Malignancies with Electrochemotherapy in a Rat Model. In: Jaroszeski, M.J., Heller, R., Gilbert, R. (eds) Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery. Methods in Molecular Medicine, vol 37. Humana Press. https://doi.org/10.1385/1-59259-080-2:319
Download citation
DOI: https://doi.org/10.1385/1-59259-080-2:319
Publisher Name: Humana Press
Print ISBN: 978-0-89603-606-2
Online ISBN: 978-1-59259-080-3
eBook Packages: Springer Protocols