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MALDI Imaging Technology Application in Neurosciences: From History to Perspectives

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Expression Profiling in Neuroscience

Part of the book series: Neuromethods ((NM,volume 64))

Abstract

Dynamic properties of the nervous system can now be investigated through mass spectrometry technologies. Generally, the application of these powerful techniques requires the destruction of the specimen under study/examination, but recent technological advances have made it possible to directly analyze tissue sections and perform 2-D or 3-D molecular ions mapping. We review from history to perspective matrix-assisted laser desorption/ionization (MALDI) imaging technology and its application to the analysis of molecular distributions of proteins and peptides in nervous tissues of both invertebrates and vertebrates, focusing in particular on recent studies of neurodegenerative diseases, and early efforts to implement assays of neuronal development.

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Acknowledgements

Research from our laboratories mentioned here has been supported by grants from the Centre National de la Recherche Scientifique Département de la politique industrielle (to MS and IF), Ministère de L’Education Nationale, de L’Enseignement Supérieur et de la Recherche, Agence National de la recherche (to IF), ARCIR Region Nord Pas de Calais (to IF).

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  1. MALDI Imaging Team, Laboratoire de Neuroimmunologie et Neurochimie Evolutives, CNRS FRE 3249, University of Lille1, Villeneuve d’Ascq, France

    Michel Salzet, Céline Mériaux, Julien Franck, Maxence Wistorski & Isabelle Fournier

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  1. Michel Salzet
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  2. Céline Mériaux
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Correspondence to Michel Salzet .

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  1. , Laboratorie de Physiopathologie de la Ba, Université d'Artois, rue Jean Souvraz 9, Lens, 62307, France

    Yannis Karamanos

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Salzet, M., Mériaux, C., Franck, J., Wistorski, M., Fournier, I. (2012). MALDI Imaging Technology Application in Neurosciences: From History to Perspectives. In: Karamanos, Y. (eds) Expression Profiling in Neuroscience. Neuromethods, vol 64. Humana Press. https://doi.org/10.1007/978-1-61779-448-3_11

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