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Flexibility in Cell Targeting by Pseudotyping Lentiviral Vectors

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Lentivirus Gene Engineering Protocols

Part of the book series: Methods in Molecular Biology ((MIMB,volume 614))

Abstract

Lentiviral vectors have become an important research tool and have just entered into clinical trials. As wild-type lentiviruses engage specific receptors that have limited tropism, most investigators have replaced the endogenous envelope glycoprotein with an alternative envelope. Such pseudotyped vectors have the potential to infect a wide variety of cell types and species. Alternatively, selection of certain viral envelope glycoproteins may also facilitate cell targeting to enhance directed gene transfer. We describe the method for generating pseudotyped vector and provide information regarding available pseudotypes and their respective target tissues.

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Acknowledgments

The author is supported in part by the Indiana Genomics Initiative (INGEN). Indiana University is the site of the NHLBI Gene Therapy Resources Program (HHSN26820078204) and the NCRR National Gene Vector Biorepository (P40 RR024928).

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  1. Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA

    Daniela Bischof & Kenneth Cornetta

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  1. Daniela Bischof
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  2. Kenneth Cornetta
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Correspondence to Kenneth Cornetta .

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  1. Div. Patogenesi dei Retrovirus, Centro Nazionale AIDS, Viale Regina Elena 299, Roma, 00161, Italy

    Maurizio Federico

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Bischof, D., Cornetta, K. (2010). Flexibility in Cell Targeting by Pseudotyping Lentiviral Vectors. In: Federico, M. (eds) Lentivirus Gene Engineering Protocols. Methods in Molecular Biology, vol 614. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-533-0_3

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  • DOI: https://doi.org/10.1007/978-1-60761-533-0_3

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  • Publisher Name: Humana Press, Totowa, NJ

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