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Lentiviral Vectors Derived from Simian Immunodeficiency Virus

  • Chapter
Lentiviral Vectors

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 261))

Abstract

The ultimate success of gene therapy to cure inherited or acquired genetic diseases relies on the development and on the availability of gene transfer vectors that can efficiently deliver a transgene following their administration in vivo. Several challenging hurdles need to be overcome to reach such a goal. A first prerequisite is that methods that allow the preparation of vectors at high titers and in culture systems with potential for large scale-up need to be optimized (ANDREADIS et al. 1999; KOTANI et al. 1994; SMITH et al. 1996). Second, the gene transfer vectors should not be recognized by the host immune system in order to avoid their inactivation (COSSET et al. 1995b; DEPOLO et al. 1999). Upon their delivery into gene therapy recipients, vectors should also be able to circumvent the numerous biological barriers that are likely to limit their diffusion and bio-distribution in the target organism. They should therefore be able to specifically recognize, penetrate and express the transgene in cells of the gene therapy target tissue (DIAZ et al. 1998; JAGER et al. 1999; RUSSELL and COSSET 1999). Third, they should be able to replicate and to express a transgene in cells that are not proliferating or are slowly proliferating, a predominant situation in vivo. Last, but not least, they should be accepted by both ethical and regulatory authorities. In this respect the development of vectors derived from viruses that are not pathogenic to humans may be preferred.

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Authors and Affiliations

  1. Laboratoire de Vectorologie Rétrovirale et Thérapie Génique, INSERM U412, Ecole Normale Supérieure de Lyon and IFR 74, Lyon, France

    D. Nègre & F.-L. Cosset

  2. Laboratoire de Thérapie Génique, CHU Hotel Dieu, Nantes, France

    G. Duisit & P. Moullier

  3. LaboRétro, U412 INSERM, IFR 74 and ENS de Lyon, Lyon, France

    P.-E. Mangeot & J.-L. Darlix

  4. 46 Allée d’Italie, 69364, Lyon Cedex 07, France

    D. Nègre

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  5. J.-L. Darlix
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  6. F.-L. Cosset
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  1. Department of Genetics and Microbiology, Faculty of Medicine, University of Geneva, CMU; 1 rue Michel-Servet, 1211, Geneva 4, Switzerland

    Didier Trono

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© 2002 Springer-Verlag Berlin Heidelberg

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Nègre, D., Duisit, G., Mangeot, PE., Moullier, P., Darlix, JL., Cosset, FL. (2002). Lentiviral Vectors Derived from Simian Immunodeficiency Virus. In: Trono, D. (eds) Lentiviral Vectors. Current Topics in Microbiology and Immunology, vol 261. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56114-6_3

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  • DOI: https://doi.org/10.1007/978-3-642-56114-6_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62667-8

  • Online ISBN: 978-3-642-56114-6

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